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Product Name: Sulfadiazine
Chemical Name: 4-Amino-N-2-pyrimidinylbenzenesulfonamide
Synonyms: p-Aminobenzenesulfonamide-2-pyrimidinyl
CAS Number: 68-35-9
Molecular Formula: C10H10N4O2S
Molecular Weight: 250.28 g/mol
Recommended Use: Pharmaceutical, antimicrobial agent
Supplier/Manufacturer: Contact details on packaging label
Emergency Contact: Refer to local Poison Control Center or supplier emergency line
GHS Classification: Acute Toxicity (Oral) Category 4, Skin Sensitization Category 1, Eye Irritation Category 2A, Specific Target Organ Toxicity (Repeated Exposure) Category 2
Signal Word: Warning
Hazard Statements: Harmful if swallowed. May cause an allergic skin reaction. Causes serious eye irritation. May cause damage to organs through prolonged or repeated exposure
Pictograms: Exclamation mark, Health hazard
Potential Health Effects: Inhalation can irritate mucous membranes. Skin contact can lead to rashes or sensitization. Ingestion brings risk of nausea, headache, or more severe poisoning at high doses. Eyes may show redness and watering.
Precautionary Statements: Avoid breathing dust. Wash hands thoroughly after handling. Contaminated work clothes should not be allowed out of the workplace. Wear protective gloves, clothing, and eye protection. If exposed or concerned, consult a doctor.
Chemical: Sulfadiazine
Percentage: 98–100%
Impurities and Stabilizers: Any relevant impurities present at under 1% individually, further details available from supplier as needed
Other Ingredients: None known to contribute to classification or hazard
Inhalation: Move affected person to fresh air, keep at rest, seek medical attention if symptoms appear or persist.
Skin Contact: Remove contaminated clothing, wash skin thoroughly with soap and water. If irritation or reaction develops, get medical advice.
Eye Contact: Immediately rinse eyes with plenty of water for at least 15 minutes, lifting upper and lower eyelids occasionally. Remove contact lenses if possible. Promptly seek medical help.
Ingestion: Rinse mouth, do not induce vomiting unless instructed by poison control or a doctor. Drink water if alert. Seek immediate medical help.
Most Important Symptoms: Allergic reactions, respiratory distress, gastrointestinal discomfort, eye irritation.
Immediate Medical Attention: Essential for significant exposure or persistent symptoms.
Suitable Extinguishing Media: Water spray, dry chemical, carbon dioxide, or foam. Avoid direct water jets.
Special Hazards: Emits toxic fumes of nitrogen oxides, sulfur oxides, and carbon oxides under fire conditions.
Protective Equipment: Wear self-contained breathing apparatus, chemical protective clothing, and gloves. Avoid inhalation of combustion products.
Advice for Firefighters: Keep containers cool with water spray. Do not discharge runoff into drains.
Personal Precautions: Use personal protective equipment. Avoid dust formation. Prevent inhalation, skin and eye contact.
Environmental Precautions: Prevent further spillage or leakage if safe, avoid releasing to waterways, drains, or soil.
Methods for Clean-Up: Sweep up and place in a suitable, closed container for disposal. Moisten powder to avoid dust dispersal. Wash spill area with water and detergent. Ventilate area.
Emergency Procedures: Evacuate unnecessary personnel. Notify authorities if contamination occurs.
Safe Handling: Avoid contact with skin, eyes, and clothing. Do not breathe dust. Work in a well-ventilated area. Wear protective gear. Practice good industrial hygiene.
Storage Conditions: Store in tightly closed containers in a cool, dry, well-ventilated place away from incompatible substances. Protect from direct sunlight and moisture. Keep out of reach of children.
Storage Incompatibles: Strong oxidizers, acids, bases.
Occupational Exposure Limits: No established OSHA/ACGIH limits for sulfadiazine; use general dust and particulate guidelines.
Engineering Controls: Local exhaust ventilation or process enclosures, eyewash stations, safety showers.
Personal Protective Equipment: Respiratory: Dust mask or respirator in insufficiently ventilated settings. Hands: Chemical-resistant gloves. Eyes: Safety goggles or face shield. Skin: Lab coat or protective suit.
Hygiene Measures: Wash hands before eating, drinking, or smoking. Change contaminated clothing.
Physical State: Solid
Appearance: White to light yellow crystalline powder
Odor: Odorless
Odor Threshold: Not applicable
pH: Slightly acidic
Melting Point/Freezing Point: 253–256°C (lit.)
Boiling Point: Decomposes before boiling
Flash Point: Not applicable
Evaporation Rate: Not available
Flammability: Not classified as flammable
Lower/Upper Explosion Limits: Not determined
Vapor Pressure: Negligible at room temperature
Vapor Density: Not available
Relative Density: About 1.44–1.54 g/cm³
Solubility in Water: Slightly soluble
Partition Coefficient (n-octanol/water): -0.09
Auto-Ignition Temperature: Not determined
Decomposition Temperature: Starts above 253°C
Viscosity: Not applicable
Chemical Stability: Stable under normal conditions if stored properly
Conditions to Avoid: Heat, flames, strong oxidizing conditions, moisture, direct sunlight
Incompatible Materials: Oxidizing agents, strong acids, bases
Hazardous Decomposition Products: Toxic gases such as nitrogen oxides, sulfur oxides, carbon oxides
Reactivity: Low reactivity in recommended storage and handling conditions
Routes of Exposure: Inhalation, skin contact, eye contact, ingestion
Acute Toxicity: Oral LD50 (rat) approximately 2000 mg/kg; may cause mild to moderate poisoning in humans through large oral doses
Possible Effects: Nausea, vomiting, headache, allergic skin reactions, anemia, crystalluria
Chronic Exposure: Kidney or liver effects, blood dyscrasias like hemolytic anemia, especially in susceptible populations (e.g., G6PD deficiency)
Carcinogenicity: Not classified as carcinogenic by IARC, NTP, OSHA
Mutagenicity/Reproductive Effects: Data suggest low potential but prolonged exposure not recommended
Symptoms of Overexposure: Allergic reactions, rash, difficulty breathing, coughing, dizziness
Ecotoxicity: Sulfadiazine can disrupt aquatic life at lower concentrations. High persistence recorded in sediment and water, with risk to algae and microorganisms.
Persistence and Degradability: Moderately persistent in the environment; partial biodegradability noted
Bioaccumulation: Not likely to bioaccumulate significantly
Mobility in Soil: Low to moderate, tends to leach slowly in moist soils
Other Adverse Effects: May encourage antibiotic resistance in natural microbial communities if released in bulk or without appropriate treatment
Waste Disposal: Collect material in a secure, labeled container. Dispose of as hazardous chemical waste in accordance with local, state, and federal regulations.
Contaminated Packaging: Dispose of containers safely, can be incinerated where permitted. Do not recycle contaminated packaging.
Precautions: Do not dispose of large quantities in general waste or drains. Avoid environmental release.
UN Number: Not regulated as dangerous goods by most international transport agencies (IATA, IMDG, DOT)
Proper Shipping Name: Sulfadiazine
Transport Hazard Class: Not classified
Packing Group: Not applicable
Environmental Hazards: Not a marine pollutant by regulation, but handle to prevent accidental release
Special Precautions: Transport in closed, upright containers. Protect from damage and moisture during transit.
TSCA Status: Listed on US TSCA Inventory
DSL/NDSL (Canada): Listed
EU Regulations: Not classified as hazardous under REACH; specific use restrictions may apply for pharmaceuticals
SARA Title III (Sections 302/304/311/312/313): Not specifically listed
California Proposition 65: Not listed
Other Regulation References: Product intended for professional use in regulated settings; observe pharmaceutical handling guidelines
