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Product Name: Streptozotocin
Synonyms: STZ, Zanosar, Streptozocin
Chemical Family: Nitrosourea derivative
CAS Number: 18883-66-4
Application: Antineoplastic agent, experimental diabetes induction
Manufacturer/Supplier: Refer to current supplier documentation
Contact Numbers: Check local regulations for poison control and supplier emergency contacts
Hazard Class: Acute Toxicity (Oral, Inhalation, Dermal), Carcinogenicity, Reproductive Toxicity
Signal Word: Danger
Hazard Statements: Fatal if inhaled, swallowed, or absorbed through skin. Suspected of causing cancer. Causes damage to organs.
GHS Pictograms: Health hazard, Skull and crossbones
Routes of Exposure: Inhalation, ingestion, dermal, eye contact
NFPA Ratings: Health 3, Flammability 0, Reactivity 1
Chemical Name: Streptozotocin
EC Number: 242-646-8
Concentration: Pure substance or as specified in product sheet
Molecular Formula: C8H15N3O7
Molecular Weight: 265.22 g/mol
Impurities: Trace organic solvents possible by synthesis method
Inhalation: Move exposed person to fresh air straight away. Keep at rest, assist breathing if necessary with oxygen administration by trained personnel. Seek immediate medical attention.
Skin Contact: Remove contaminated clothing, rinse skin thoroughly with plenty of water and soap. Discard or decontaminate clothing. Consult a medical professional right after skin exposure.
Eye Contact: Flush eyes gently with water for at least 15 minutes, holding eyelids open. Remove contact lenses if worn. Immediate doctor consultation is needed.
Ingestion: Rinse mouth with water. Do not induce vomiting. If the person is conscious, offer water. Immediate medical intervention is required.
Most Important Symptoms: Nausea, vomiting, diarrhea, abdominal pain, respiratory distress, convulsions, systemic toxicity
Note to Physician: Treat symptomatically and monitor for delayed effects on nervous system, liver, kidneys
Suitable Extinguishing Media: Water spray, foam, dry chemical, carbon dioxide
Unsuitable Media: Avoid use of water jet directly on burning material
Specific Hazards: Product may emit toxic fumes of nitrogen oxides, carbon monoxide, and carbon dioxide under fire
Protective Equipment: Firefighters use full protective suit and self-contained breathing apparatus
Firefighting Instructions: Isolate area, evacuate personnel from danger zone, prevent contaminated extinguishing water from entering sewage systems or bodies of water
Personal Precautions: Limit access to spill area, ventilate location, avoid breathing dust or vapors, use personal protective equipment including gloves, mask with particle filter, laboratory coat
Environmental Precautions: Prevent runoff into drains, surface waters, and soil. Collect spillage in closed, labeled containers
Clean-Up Methods: Scoop up spill using non-sparking tools. Moisten solid dust to reduce particles in air. Clean contaminated surface using detergent, avoid creating dust or aerosol
Disposal: Dispose in accordance with local, regional, and national regulations. Avoid direct contact with skin and eyes during clean-up
Handling: Always handle in chemical fume hood or well-ventilated space. Avoid inhaling, touching with unprotected skin, or accidental eye contact. Use protective clothing, gloves, safety goggles, and certified respiratory protection when risk of exposure exists. Keep container tightly closed and avoid generating dust.
Storage: Store in secure, labeled containers within refrigerator or freezer (-20°C preferred). Avoid prolonged exposure to light, moisture, or incompatible materials such as strong oxidants or acids. Keep away from food and incompatible chemicals. Regularly check container integrity.
Engineering Controls: Negative pressure chemical fume hood, local exhaust ventilation, closed system if possible, regularly checked functional air filtration
Respiratory Protection: Approved respirator, especially NIOSH/MSHA certified half-mask with particle filter P100, for dusts and aerosols
Hand Protection: Impervious chemical-resistant gloves (nitrile recommended), double gloving for high-risk procedures
Eye Protection: Chemical splash goggles or full-face shield
Skin and Body: Fully buttoned laboratory coat, disposable gown, closed footwear, avoid exposure of any bare skin
Hygiene Practices: Avoid ingestion, chewing or smoking in work area. Wash hands and face after handling, before breaks or meals. Remove contaminated clothing after work, launder separately.
Appearance: White to pale yellow crystalline powder
Odor: Odorless
pH (solution): Approx. 4.5–6.0 (1% in water)
Melting Point: 177 °C (decomposes before melting)
Boiling Point: Not applicable (decomposes)
Solubility: Very soluble in water, slightly soluble in ethanol
Density: Approx. 1.67 g/cm³
Partition Coefficient (n-octanol/water): Not available
Vapor Pressure: Not applicable (non-volatile solid)
Flash Point: Not relevant
Decomposition Temperature: Above 177 °C
Chemical Stability: Stable under recommended storage conditions, decomposes on exposure to light, high temperatures, or moisture
Conditions to Avoid: Light, heat, open air, high humidity, contact with incompatible chemicals
Incompatible Materials: Strong acids, oxidizers, reducing agents
Hazardous Decomposition Products: Toxic gases including nitrogen oxides, carbon monoxide, and carbon dioxide
Polymerization: Does not occur under normal handling, but decomposition increases with higher temperatures or contamination
Acute Toxicity: LD50 (oral, rat): 110 mg/kg; LD50 (intravenous, mouse): 225 mg/kg
Target Organs: Pancreas, kidney, liver, nervous system
Potential Health Effects: Nausea, vomiting, renal failure, hypoglycemia, neurotoxicity, fatigue, increased risk of cancer
Carcinogenicity: Classified as possible human carcinogen by IARC Group 2B
Reproductive Toxicity: May impair fertility, teratogenic effects observed in animal studies
Mutagenicity: Causes genetic mutations in laboratory assays
Other Effects: Prolonged or repeated exposure causes cumulative organ toxicity, suspected link to permanent diabetes in experimental animals
Ecotoxicity: Very toxic to aquatic life, harmful in the environment due to persistent organic toxicity
Mobility: Highly soluble, can move readily in water and soil environments
Degradation: Slowly breaks down in water; photodegradation possible only with intense UV
Bioaccumulation: Not likely significant, but acute exposure threatens exposed fauna
Chronic Environmental Effects: Detrimental to local water treatment microflora, toxic to invertebrates and fish in low concentrations
Waste Handling: Treat as hazardous waste, use suitable sealed containers. Avoid landfill or sewer disposal, incinerate in a licensed chemical incinerator with afterburner and scrubber.
Precautions: Personnel must follow chemical hygiene plans and wear protective equipment.
Contaminated Packaging: Dispose of or decontaminate using approved high-temperature, high-efficiency waste procedures.
UN Number: 2811
Proper Shipping Name: Toxic Solid, Organic, N.O.S. (Streptozotocin)
Transport Hazard Class: 6.1 (Toxic Substance)
Packing Group: II
Label: Toxic Substance
Marine Pollutant: Not classified, but avoid aquatic release
Additional Information: Shipment should comply with International Air Transport Association (IATA) and Department of Transportation (DOT) or regional requirements. Transport only in tightly sealed, labeled packaging with documentation.
OSHA: Regulated as hazardous under Hazard Communication Standard
SARA Title III: Not listed for Section 302, 313; consult Section 311 as hazardous chemical
TSCA: Listed
EU Regulation: Classified as carcinogenic, toxic; subject to REACH regulation
Other National/Local Regulations: Specific country requirements may apply. Always verify for laboratory and workplace safety requirements.
