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Product Name: Streptomycin Sulfate Injection Grade
Chemical Formula: (C21H39N7O12)2·H2SO4
Synonyms: Streptomycin, Streptomycin Sulphate, Streptomycin Disulfate Salt
CAS Number: 3810-74-0
Recommended Uses: Pharmaceutical, veterinary use, laboratory reagent
Manufacturer Information: Name, address, emergency telephone number, and email provided on package insert
GHS Classification: Eye irritation (Category 2A), Respiratory sensitizer (Category 1), Skin sensitizer (Category 1), Reproductive toxicity (Category 2), Specific target organ toxicity – repeated exposure (Category 2)
GHS Label Elements: Warning; exclamation mark symbol
Hazard Statements: Causes serious eye irritation, may cause allergy or asthma symptoms, may cause an allergic skin reaction, suspected of damaging fertility or the unborn child, may cause damage to organs through prolonged or repeated exposure
Precautionary Statements: Avoid breathing dust or mists, wash skin thoroughly, wear protective gloves and clothing, use only outdoors or in well-ventilated area
Pictograms: Exclamation mark, health hazard symbol
Emergency Overview: White to off-white powder; may cause sensitization by inhalation or skin contact; avoid direct contact
Chemical Name: Streptomycin sulfate
Common Name: Streptomycin
Concentration: 95% to 100% Streptomycin sulfate
Impurities: Water, trace organic and inorganic impurities within pharmacopeia limits
Molecular Weight: 1457.4 g/mol (streptomycin sulfate)
Inhalation: Remove person from exposure area, seek medical advice if symptoms like coughing or shortness of breath develop; provide oxygen if breathing becomes difficult
Skin Contact: Remove contaminated clothing, wash exposed area thoroughly with soap and water; seek medical attention in case of irritation or allergic response
Eye Contact: Rinse cautiously with clean water for several minutes, remove contact lenses if present, call a physician
Ingestion: Rinse mouth, obtain medical advice; do not induce vomiting unless directed by medical personnel
Most Important Symptoms: Sensitization reactions, respiratory irritation, skin or eye redness
Special Notes for Physicians: Treat supportively based on symptoms, monitor for allergic reactions or respiratory difficulties
Suitable Extinguishing Media: Water spray, dry chemical, foam, carbon dioxide
Unsuitable Extinguishing Media: High-pressure water streams may spread material
Specific Hazards: Decomposes under fire conditions releasing toxic fumes of carbon oxides, nitrogen oxides, sulfur oxides
Protective Equipment for Firefighters: Wear self-contained breathing apparatus and full protective gear
Firefighting Instructions: Move containers from area if safe, prevent firewater from entering drains, stay upwind
Personal Precautions: Avoid breathing dust, ensure adequate ventilation, wear appropriate PPE including dust mask, gloves, lab coat
Environmental Precautions: Prevent material from entering waterways and drains; notify appropriate authorities if large spill occurs
Containment and Clean-Up: Pick up material without raising dust using disposable towels, collect in suitable container for disposal, decontaminate with water and detergent, ventilate area
Spillage Handling: Use non-sparking tools, avoid unnecessary personnel in area
Precautions for Safe Handling: Use in well-ventilated areas, avoid inhalation or contact with skin and eyes, wash thoroughly after handling, wear appropriate PPE
Storage Conditions: Keep in original tightly closed container, store in cool, dry, well-ventilated place away from moisture, direct sunlight, oxidizers
Special Storage Requirements: Store at controlled room temperature (15-30°C); avoid freezing; segregate from incompatible materials such as strong acids or bases
Exposure Limits: Occupational exposure limits are not specifically established for streptomycin; minimize exposure as with pharmaceutical actives
Engineering Controls: Ensure adequate local exhaust and general ventilation, fume hoods or biosafety cabinets for dust generating procedures
Personal Protective Equipment: Protective gloves (nitrile or latex), laboratory coat, safety glasses or eye shield, NIOSH-approved dust mask or respirator as required
Hygiene Measures: Do not eat, drink, or smoke in work area; wash hands thoroughly after handling; remove contaminated clothing before leaving work area
Appearance: White to off-white crystalline powder
Odor: Odorless
Odor Threshold: Not determined
pH: 4.0 – 7.0 (solution)
Melting Point/Freezing Point: Decomposes before melting
Boiling Point: Not applicable
Flash Point: Not flammable
Evaporation Rate: Not available
Flammability: Not flammable
Vapor Pressure: Not available
Vapor Density: Not applicable
Relative Density: ~1.4 g/cm³
Solubility: Freely soluble in water
Partition Coefficient (log Kow): Not available
Auto-Ignition Temperature: Not determined
Decomposition Temperature: Above 195°C (with degradation)
Viscosity: Not relevant for solid
Chemical Stability: Stable under recommended conditions of storage
Reactivity: No dangerous reactions expected under normal use
Conditions to Avoid: Moisture, excessively high temperatures, direct light, strong oxidizing agents
Incompatible Materials: Acids, bases, oxidizers
Hazardous Decomposition Products: Nitrogen oxides, sulfur oxides, carbon monoxide, carbon dioxide
Polymerization: Product does not undergo hazardous polymerization
Routes of Exposure: Inhalation, skin contact, eye contact, ingestion
Acute Toxicity: LD50 (oral, mouse): 6200 mg/kg; no human LD50 available
Chronic Effects: May cause allergic reactions, hearing damage (ototoxicity), and kidney injury with long-term exposure or therapeutic overdose
Symptoms: Skin rash, redness, asthma symptoms, eye irritation, nausea, hearing loss, vestibular dysfunction
Sensitization: Skin and respiratory sensitizer; may cause allergy
Carcinogenicity: Not listed as carcinogenic by NTP, IARC, or OSHA
Mutagenicity & Teratogenicity: Some evidence of reproductive and developmental toxicity in animal studies; suspected harm to unborn child
Other Data: Health workers exposed to powder may develop allergies or asthma
Ecotoxicity: Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment
Persistence and Degradability: Only slowly biodegradable; pharmaceutical residues may persist
Bioaccumulative Potential: Low bioaccumulation expected
Mobility in Soil: Readily soluble, potential for leaching into groundwater; may contaminate watercourses
Other Adverse Effects: Antibiotic resistance development risk in environmental bacteria with improper disposal or runoff
Precautions: Prevent large releases to environment; treat all waste streams for pharmaceutical load
Waste Treatment Methods: Dispose through licensed hazardous pharmaceutical waste contractor
Contaminated Packaging: Treat packaging as hazardous waste if contaminated; rinse and incinerate when possible
Product Disposal: Incineration recommended; avoid landfill or sewer; abide by federal, state, and local regulations
Precautions for Disposal: Do not discharge into drains, soil, or water bodies; notify authorities of large spills
UN Number: Not regulated as hazardous material under ADR, IMDG, IATA
UN Proper Shipping Name: Not applicable
Transport Hazard Class: Not classified
Packing Group: Not applicable
Environmental Hazards During Transport: Not a marine pollutant
Special Transport Precautions: Ship in closed, labeled containers; protect from excessive heat and humidity; avoid crushing of packaging
U.S. Regulations: This compound is subject to prescription drug regulations under the FD&C Act; not listed by OSHA as hazardous chemical
Europe: Classified according to Regulation (EC) No 1272/2008 (CLP/GHS)
Other Global Inventories: Subject to local regulations; comply with drug and environmental safety requirements
SARA Title III: Not subject to Sections 302, 304, 311, 312, or 313 reporting
REACH: Pharmaceutical substances regulated under exemptions for human and veterinary medicinal products
Other Information: Observe all workplace, state, local, and national regulations regarding handling and disposal
