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Product Name: Staurosporine
Chemical Family: Indolocarbazole alkaloid
Chemical Formula: C28H26N4O3
Molecular Weight: 466.54 g/mol
Synonyms: Antibiotic AM-2282, STS
CAS Number: 62996-74-1
Manufacturer: Various laboratory chemical suppliers
Recommended Use: Laboratory reagent, kinase inhibitor research
Restrictions on Use: Not for drug, household, or other uses
Hazard Class: Acute toxicity (oral, dermal, inhalation), skin and eye irritant
Label Elements: Skull and crossbones, exclamation mark
Signal Word: Danger
Hazard Statements: May cause organ damage, toxic if swallowed, causes damage to eyes and skin, suspected of causing genetic defects, may cause cancer
Routes of Entry: Inhalation, ingestion, skin and eye contact
Target Organs: Liver, kidneys, nervous system
Symptoms of Exposure: Nausea, vomiting, headache, irritation to eyes, skin, and respiratory tract
Chemical Identity: Staurosporine
Concentration: >98% pure
Impurities: Trace organic solvents depending on supplier
Inert Ingredients: None reported for analytical powder
EC Number: 263-692-2
Inhalation: Move to fresh air, keep person at rest, seek medical attention if symptoms persist
Ingestion: Rinse mouth with water, do not induce vomiting, seek immediate medical advice
Skin Contact: Wash affected area with soap and water, remove contaminated clothing, consult a physician
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses if present, continue rinsing, get medical help
Notes to Physician: Symptomatic treatment and supportive care, monitor for delayed effects on organs
Suitable Extinguishing Media: Dry chemical, CO2, foam, water spray
Unsuitable Extinguishing Media: High pressure water jet can spread powder
Specific Hazards: May release toxic fumes including CO, NOx, hydrogen cyanide under fire conditions
Protective Equipment: Self-contained breathing apparatus with full protective suit
Advice for Firefighters: Avoid inhaling vapors or dust, control run-off, contain firewater
Personal Precautions: Wear appropriate PPE including gloves and goggles, avoid breathing dust, prevent skin and eye contact
Environmental Precautions: Prevent further leakage or spillage if safe, keep out of drains, surface and ground water
Containment Methods: Absorb on sand, vermiculite or inert absorbent, collect in tightly closed containers for disposal
Cleaning Methods: Wipe up with damp cloth or mop, ventilate area
Notification: Inform responsible authorities if large quantities enter waterways
Safe Handling: Avoid contact with skin, eyes, clothing, do not breathe dust or vapors, employ local exhaust ventilation
Storage Conditions: Keep tightly closed in a cool, dry, well-ventilated place, protect from light
Incompatibilities: Strong oxidizers, acids and bases
Hygiene Measures: Wash hands thoroughly after handling, do not eat, drink, or smoke in working area
Specific Prohibitions: Avoid containment with incompatible materials, maintain clean workspace
Exposure Limits: No official occupational exposure limits established
Engineering Controls: Use chemical fume hood, laboratory grade ventilation
Respiratory Protection: NIOSH/MSHA-approved respirator if dust or aerosol is generated
Eye Protection: Safety goggles with side shields
Skin Protection: Chemical resistant gloves (nitrile recommended), laboratory coat
Environmental Controls: Prevent product from entering environment, use containment to avoid release
Physical State: Solid powder or crystalline
Color: Off-white to light yellow
Odor: Odorless or faint chemical odor
pH: Not available
Melting Point: 237–239°C
Boiling Point: Not applicable
Solubility: Soluble in DMSO, methanol, ethanol, poorly soluble in water
Partition Coefficient: Log P (octanol/water): 3.4 (estimated)
Vapor Pressure: Not relevant under normal conditions
Flash Point: Not available
Decomposition Temperature: >200°C
Density: Not determined
Viscosity: Not applicable
Chemical Stability: Stable under recommended storage conditions
Reactivity: No hazardous reactivity under normal use
Polymerization: Will not occur
Hazardous Decomposition Products: CO, CO2, nitrogen oxides, hydrogen cyanide possible on thermal decomposition
Incompatible Materials: Strong oxidizers, acids, bases
Conditions to Avoid: Excess heat, exposure to light, moisture
Acute Toxicity: Highly toxic by ingestion, inhalation, and contact; LD50 (oral, rat): approx. 1–2 mg/kg
Chronic Effects: May damage genetic material, probable human carcinogen, reproductive toxin
Sensitization: Risk of skin and respiratory sensitization
Symptoms of Overexposure: Nausea, vomiting, headache, organ failure in severe cases, strong irritation of skin/eyes
Routes of Exposure: Accidental ingestion, inhalation of dust, direct contact
Aquatic Toxicity: Harmful to aquatic organisms, may cause long-term adverse effects
Persistence/Degradability: Not rapidly biodegradable, high potential for persistence in the environment
Bioaccumulation Potential: Moderate potential based on log P
Mobility in Soil: Expected to have low mobility due to poor solubility in water
Other Ecological Effects: Product and waste should not enter environment, wastewater, or soil
Waste Disposal Methods: Treat as hazardous chemical waste, dispose at licensed facility
Contaminated Packaging: Dispose as hazardous waste, do not reuse containers
Regulations: Comply with federal, state, and local disposal regulations
Do Not: Discharge to sewers, surface water, or soil
Recycling: Not recommended for this material
UN Number: 2811
Proper Shipping Name: Toxic solid, organic, n.o.s. (Staurosporine)
Transport Hazard Class: 6.1 (Toxic substances)
Packing Group: II
Labels: Toxic
Special Precautions: Avoid release during transport, follow all regulatory requirements
Marine Pollutant: Not listed as a marine pollutant, but avoid environmental exposure
TSCA: Not listed on the US EPA TSCA inventory for commercial use
OSHA: Acute toxin, handle as hazardous chemical
SARA Title III: Not specifically listed, but general chemical hazard rules apply
California Proposition 65: Not evaluated, treat as potential carcinogen
WHMIS Classification (Canada): D1A (Very Toxic Material), D2A (Potentially Carcinogenic)
REACH Status (Europa): Not registered as bulk chemical
Other Regulations: Handle according to recognized chemical safety standards, laboratory best practices
