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Product Name: Spiramycin or Spiramycin Base
Other Names: 4'-(5-O-Desmethyl-2,3,4,6-tetradeoxy-3-dimethylamino-β-L-lyxo-hexopyranosyloxy)-2,3,4,6,8,9,10,11,12,13,14,15,16,17,18,19,20-nonadecaoxo-1,21,22,23,24-pentacosane
Chemical Formula: C43H74N2O14 (representative structure)
CAS Number: 8025-81-8
Recommended Use: Veterinary antibiotic, pharmaceutical ingredient
Manufacturer/Supplier: Identify supplier or pharmaceutical company
Emergency Contact: Provide 24-hour emergency phone numbers where available
Classification: Harmful if swallowed; potential for respiratory, skin, or eye sensitization
GHS Label Elements: Warning; Harmful if inhaled or ingested
Hazard Statements: May cause allergic reactions in sensitive individuals, possible irritation to skin, eyes, and respiratory tract
Precautionary Statements: Avoid breathing dust or fumes, wash hands thoroughly after handling, use necessary protective equipment
Potential Health Effects: Eyes—irritation, redness; Skin—prolonged contact may cause sensitization; Inhalation—respiratory tract irritation, coughing; Ingestion—nausea, vomiting, abdominal cramps
Chemical Name: Spiramycin base
Purity: Not less than 95% active ingredient
Impurities: Related macrolide compounds and byproducts less than 5%
Additives: Trace stabilizers, residual solvents possibly below 0.1%
Molecular Weight: 843.05 g/mol (base compound)
Eye Contact: Rinse immediately with plenty of water, seek medical advice if irritation persists
Skin Contact: Wash affected skin with soap and water, seek help if irritation continues
Inhalation: Move to fresh air, seek immediate medical attention if symptoms develop
Ingestion: Rinse mouth with water, do not induce vomiting, seek medical attention
Advice to Physicians: Treat symptomatically, monitor for allergic response or respiratory distress
Suitable Extinguishing Media: Carbon dioxide, dry chemical, foam, water spray
Unsuitable Media: Jet of water may spread the powder
Specific Hazards: Emits toxic fumes of carbon oxides and nitrogen oxides under fire conditions
Protective Equipment for Firefighters: Self-contained breathing apparatus with full face shield, protective clothing
Special Procedures: Prevent runoff from entering drains, use caution to minimize dust formation
Personal Precautions: Evacuate unnecessary personnel, ventilate area, wear protective gear
Spill Cleanup: Avoid raising dust, collect spill with a suitable tool, dispose in a sealed container
Environmental Precautions: Prevent product from entering drains or water courses
Decontamination: Wash spill site thoroughly with water and mild detergent after removal
Handling: Use with adequate local exhaust ventilation, avoid contact with skin, eyes, and clothing, avoid inhaling dust
Storage Conditions: Store in a tightly closed container, in a cool, dry, well-ventilated area protected from sunlight
Incompatibility: Avoid reactive agents, strong oxidizers, acids, alkalis
Hygiene Practices: Keep away from food and drink, wash hands thoroughly after handling, do not smoke during use
Exposure Limits: No established occupational exposure limits, use caution to avoid chronic exposure
Engineering Measures: Keep area ventilated, use enclosures or process controls to prevent airborne exposure
Personal Protection: Wear suitable gloves (nitrile recommended), safety goggles, laboratory coat or full protective clothing, dust mask or respirator if risk of inhalation exists
Environmental Controls: Prevent contamination of soil, water sources, and drains
Appearance: White to off-white crystalline powder
Odor: Faint, characteristic pharmaceutical odor
pH (1% solution): 8.5–10.5
Melting Point: Not clearly defined, decomposes at high temperatures
Solubility: Slightly soluble in water, soluble in methanol, chloroform
Boiling Point: Polymerizes or decomposes before boiling
Stability: Sensitive to light and moisture
Vapor Pressure: Not measurable, as it is a non-volatile solid
Chemical Stability: Stable in original packaging under recommended storage conditions
Conditions to Avoid: Excess heat, humidity, direct sunlight, contact with incompatible materials
Hazardous Decomposition: Produces carbon monoxide, carbon dioxide, nitrogen oxides when heated to decomposition
Reactivity: No hazardous polymerization, avoid contact with oxidizing agents and acids
Acute Toxicity: Oral LD50 (rat) > 2000 mg/kg (low toxicity range)
Local Effects: May cause mild irritation, contact dermatitis in sensitive individuals
Chronic Exposure: Repeated or prolonged exposure may lead to sensitization of skin or lungs
Allergenic Effects: Macrolides have documented risks for hypersensitivity in some humans
Carcinogenicity: No evidence from available studies for carcinogenic risks
Mutagenicity: No in vitro mutagenic effects detected in standard tests
Reproductive Toxicity: Not established, avoid non-essential exposure for pregnant personnel
Toxicity to Aquatic Life: Harmful in larger quantities, especially to aquatic organisms
Persistence and Degradability: Limited biodegradation in water and soil, persistence possible if released
Bioaccumulation: Low potential for bioaccumulation
Soil Mobility: Moderate mobility expected, caution advised to prevent entry into groundwater
Other Adverse Effects: Release to the environment can promote resistance among bacterial species
Product Disposal: Dispose according to local, regional, and national regulations relating to antibiotics or pharmaceuticals
Contaminated Packaging: Triple rinse and incinerate or send to approved hazardous waste site
Waste Treatment: Avoid disposal into surface water or municipal sewage systems
UN Number: None assigned, not regulated as a hazardous material under typical classifications
Proper Shipping Name: Not restricted
Transport Hazard Classes: Not classified as hazardous for transportation
Packing Group: Not assigned
Special Precautions: Keep protected from physical damage, moisture, and direct sunlight during transit
International Regulations: Ingredient may fall under prescription pharmaceutical regulations in many countries
Safety/Health/Environmental: OSHA not specifically regulated, but hazard communication rules apply; EC Classification—Xi (irritant), R43 (may cause sensitization by skin contact)
Inventory Listings: Listed or exempted on chemical inventories in major jurisdictions (such as EINECS, TSCA, etc.)
Labelling: Ensure packaging and safety data sheet labelling complies with CLP, GHS, and local workplace safety requirements
