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Material Safety Data Sheet: Spectinomycin Hydrochloride Pentahydrate

Identification

Product Name: Spectinomycin Hydrochloride Pentahydrate
Synonyms: Actinospectacin Hydrochloride, Spectam
CAS Number: 10049-17-9
Recommended Uses: Antibiotic agent in veterinary and laboratory settings
Manufacturer: Data specific to supplier/distributor
Emergency Contact: Refer to supplier or local emergency services for immediate assistance
Chemical Family: Aminocyclitol Aminoglycosides

Hazard Identification

GHS Classification: Not classified as hazardous under GHS
Label Elements: No specific pictogram or signal word required in most jurisdictions
Health Hazards: May cause irritation to skin, eyes, and respiratory tract; allergic reactions possible
Environmental Hazards: Harmful to aquatic life with long-lasting effects
Precautionary Statements: Avoid breathing dust; wear protective gloves and eye protection; wash hands thoroughly after handling

Composition / Information on Ingredients

Chemical Name: Spectinomycin Hydrochloride Pentahydrate
Concentration: ≥98% (typical laboratory grade)
Molecular Formula: C14H24N2O7•HCl•5H2O
Molecular Weight: 495.88 g/mol
Impurities: Trace related substances (refer to certificate of analysis for details)
Hazardous Components: No components classified as hazardous

First Aid Measures

Inhalation: Move person to fresh air; contact physician if irritation or symptoms develop
Skin Contact: Wash thoroughly with soap and water; remove contaminated clothing
Eye Contact: Rinse immediately with plenty of water for at least 15 minutes, seek medical attention if irritation persists
Ingestion: Rinse mouth with water; obtain medical attention if symptoms appear
Acute/Delayed Symptoms: Possible respiratory, skin, or eye irritation; possible allergic reactions in sensitized individuals

Fire-Fighting Measures

Suitable Extinguishing Media: Use water spray, dry chemical, foam, or carbon dioxide
Unsuitable Media: Avoid direct water stream to prevent spread
Fire Hazards: Product is not highly flammable, but may emit toxic fumes (nitrogen oxides, hydrochloric acid, carbon oxides) if heated to decomposition
Protective Equipment: Firefighters should use self-contained breathing apparatus and full protective clothing
Special Procedures: Cool fire-exposed containers with water; contain and collect contaminated water

Accidental Release Measures

Personal Precautions: Avoid contact with skin and eyes; use recommended personal protective equipment
Environmental Precautions: Prevent release to drains, sewers, or waterways
Clean-Up Methods: Ventilate area; collect spilled material using non-sparking tools; sweep up and place in suitable container for disposal
Disposal: Treat as pharmaceutical waste and follow local regulations for disposal

Handling and Storage

Handling: Work in a well-ventilated area; minimize dust generation; do not eat, drink, or smoke while handling
Storage Conditions: Keep container tightly closed; store at 2–8°C (refrigerated); protect from light and moisture
Incompatible Materials: Strong oxidizers, reducing agents
Hygiene Practices: Wash hands thoroughly after use; avoid splashing and aerosol formation

Exposure Controls and Personal Protection

Occupational Exposure Limits: No established limits; handle with pharmaceutical best practices
Engineering Controls: Laboratory-grade ventilation or fume hood recommended
Personal Protection: Chemical-resistant gloves (nitrile or latex), safety goggles, laboratory coat, and mask or respirator if dust is generated
Environmental Controls: Prevent dispersion to environment using local exhaust and containment

Physical and Chemical Properties

Appearance: White to off-white crystalline powder
Odor: Odorless
Odor Threshold: Not applicable
pH (in solution): 3.0 - 5.0 (1% aqueous solution)
Melting Point: 158–160 °C (decomposition begins); water of crystallization may be lost below this temperature
Solubility: Freely soluble in water; slightly soluble in methanol; practically insoluble in ether
Boiling Point: Not applicable
Flash Point: Not flammable
Vapor Pressure: Negligible at room temperature
Partition Coefficient (log P): Data not available
Evaporation Rate: Not applicable
Auto-ignition Temperature: Not self-igniting
Density: Not established

Stability and Reactivity

Chemical Stability: Stable under normal temperatures and recommended storage
Reactivity: No dangerous reactions expected during normal use
Conditions to Avoid: Excessive moisture, strong heat, prolonged exposure to light
Incompatible Materials: Strong oxidizers, strong acids and bases
Hazardous Decomposition: May produce HCl, COx, NOx during thermal decomposition

Toxicological Information

Routes of Exposure: Inhalation, ingestion, skin and eye contact
Acute Toxicity: LD50 (oral, rat): > 5000 mg/kg (low acute toxicity)
Skin Corrosion/Irritation: May cause mild irritation, especially in sensitive individuals
Eye Damage/Irritation: May cause irritation
Respiratory Sensitization: Not established, but dust may trigger symptoms in pre-existing respiratory conditions
Carcinogenicity: Not considered carcinogenic (IARC, NTP, OSHA)
Mutagenicity: Data indicate no significant mutagenic effects
Reproductive Toxicity: No effects observed in most studies, but handle with care
Long-term Effects: May induce allergic reactions in sensitive individuals

Ecological Information

Ecotoxicity: May be toxic to aquatic organisms; long-term adverse effects possible
Persistence and Degradability: Partially biodegradable; stays in water and soil for extended periods
Bioaccumulative Potential: Low likelihood to bioaccumulate
Mobility in Soil: Significant mobility - moves with runoff or water
Other: Avoid release into environment or sewage system

Disposal Considerations

Waste Treatment Methods: Dispose through approved chemical waste/disposal contractor
Product Disposal: Small quantities can be diluted and incinerated or landfilled in compliance with local regulations
Contaminated Packaging: Triple rinse containers, then dispose as chemical waste
Sewage Prohibition: Do not discharge to wastewater or environment

Transport Information

UN Number: Non-regulated for transport
Proper Shipping Name: Not classified as hazardous for transport (road, air, sea)
ADR/RID/IMDG/ICAO/IATA: No specific dangerous goods classification
Packing Group: Not applicable
Special Precautions: Protect from moisture during transport; keep in original tightly sealed container

Regulatory Information

International Inventories: Listed on major chemical inventories (e.g., EINECS/ELINCS, TSCA)
OSHA Hazards: Not defined as hazardous under U.S. OSHA regulations
WHMIS Classification: Not controlled under WHMIS
SARA Title III: No reportable quantities
Other Regulations: Follow national and local laws relating to pharmaceuticals and antibiotics; handle in accordance with safe use guidelines as determined by regulatory authorities