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Product Name: Sofosbuvir
Chemical Name: 2'-Deoxy-2'-fluoro-2'-C-methyluridine Phosphoramidate Prodrug
CAS Number: 1190307-88-0
Molecular Formula: C22H29FN3O9P
Molecular Weight: 529.45 g/mol
Recommended Use: Research, pharmaceutical intermediate, medication ingredient
Supplier: Pharmaceutical manufacturer or supplier details per bottle
Emergency Phone Number: Refer to product label or company for local emergency contacts
GHS Classification: Not classified as hazardous under GHS criteria, though caution remains necessary
Signal Word: None
Hazard Statements: Avoid prolonged or repeated exposure; possible irritation to eyes, skin, and respiratory tract
Precautionary Statements: Wear recommended personal protective equipment; prevent dust formation; clean spills promptly
Other Hazards: Healthcare workers handling product in bulk may face higher risk if controls lapse; improper handling could cause minor irritation or sensitization in predisposed individuals
Chemical Identity: Sofosbuvir
Concentration: 100% (pure active ingredient)
Impurities: Trace solvents or excipients only where applicable, specific to supplier or manufacturer
Synonyms: PSI-7977, GS-7977
Form: Crystalline solid
Eye Contact: Rinse immediately with plenty of water for 15 minutes, seek medical attention if irritation or vision changes persist
Skin Contact: Remove contaminated clothing; wash skin thoroughly with soap and water; medical attention recommended for persistent symptoms
Inhalation: Remove to fresh air; monitor for respiratory symptoms; medical evaluation needed for persistent discomfort
Ingestion: Do not induce vomiting; rinse mouth thoroughly; seek medical care; provide product information
Most Important Symptoms: Possible mild irritation to eyes, skin, or mucous membranes
Suitable Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or foam depending on surrounding fires
Unsuitable Extinguishing Media: Avoid high-pressure water jets for direct application
Specific Hazards: Thermal decomposition generates carbon oxides, nitrogen oxides, phosphorus oxides, hydrofluoric acid fumes
Protective Equipment: Firefighters should use self-contained breathing apparatus and protective clothing
Advice for Firefighters: Avoid inhalation of dust and combustion products; prevent contaminated runoff into water supplies
Personal Precautions: Use personal protective equipment including gloves, goggles, and dust mask; prevent dust formation
Environmental Precautions: Prevent product from entering drains and waterways
Cleanup Methods: Sweep up and shovel spill using non-sparking tools; store in suitably labeled sealed containers for disposal; ventilate area
Disposal: Dispose collected material as hazardous chemical waste following local and national regulations
Safe Handling Guidelines: Work in well-ventilated locations; wear protective gear; avoid dusting and minimize direct contact; practice good hygiene after use
Storage Conditions: Store in original container in a cool, dry, and well-ventilated area away from incompatible substances; keep tightly closed
Incompatibilities: Avoid storing with oxidizers, acids, or strong bases; isolated from food and drink
Control Parameters: No specific occupational exposure limits established for Sofosbuvir
Engineering Controls: Use process enclosures, local exhaust ventilation, or other controls to keep airborne levels below unregulated exposure guidelines
Personal Protective Equipment: Use safety glasses with side shields, nitrile gloves, and laboratory coats; consider dust masks or respirators if significant dust hazards
Hygiene Measures: Wash thoroughly after handling; do not eat, drink, or smoke while handling material
Appearance: White to off-white crystalline powder
Odor: Odorless
Odor Threshold: Not applicable
pH: Not available for solid; solution pH varies
Melting Point: 126–129°C
Boiling Point: Not determined
Flash Point: Not determined
Evaporation Rate: Not applicable
Flammability: Not flammable in expected conditions of use
Vapor Pressure: Negligible
Vapor Density: Not applicable
Solubility: Slightly soluble in water and common organic solvents
Partition Coefficient: logP entries not widely published
Decomposition Temperature: Degrades above melting point
Viscosity: Not applicable
Chemical Stability: Stable under recommended handling and storage conditions
Reactivity: No known specific reactions with ordinary substances
Hazardous Reactions: Risks increase if mixed with strong oxidizers or acids
Conditions to Avoid: High temperature, moisture, and incompatible substances
Decomposition Products: Carbon monoxide, carbon dioxide, fluorinated gases, acidic fumes
Acute Toxicity: Animal studies using high doses show low acute oral and dermal toxicity
Skin Corrosion/Irritation: Not classified; minor irritation possible with significant exposure
Serious Eye Damage/Irritation: Dust or powder may cause mild transient irritation
Respiratory Sensitization: No evidence currently available, but chronic inhalation should be avoided
Carcinogenicity: No components listed as carcinogenic by IARC, ACGIH, NTP, OSHA
Reproductive or Developmental Effects: Animal studies in pharmaceutical context show no teratogenicity at expected exposure levels; not intended for pregnant or lactating handlers
Specific Organ Toxicity: Target organ effects have not been reported at expected environmental or occupational exposures
Mutagenicity: In vitro tests yielded negative or equivocal results; relevance to occupational exposure remains low
Ecotoxicity: Limited data; drug compounds may pose risk to aquatic environments in large quantities; pharmaceutical products should always be kept away from drains
Persistence and Degradability: Partial degradation in natural environments; halo-organic components require controlled disposal
Bioaccumulative Potential: No significant bioaccumulation expected based on structure
Mobility in Soil: Moderate, depends on physical form and local conditions
Other Adverse Effects: Unused medication should not be released to surface waters—impact data limited, but pharmaceuticals as a class are monitored due to possible non-target effects
Disposal Methods: Incineration in a facility equipped for pharmaceuticals or hazardous materials disposal; chemical waste bins in labs
Container Disposal: Rinse empty containers prior to disposal; follow local guidelines for hazardous chemical packaging
Precautions: Never dispose via sinks, toilets, or general trash; take to certified chemical disposal centers only
Waste Codes: Check local regulatory waste codes since not all regions classify pharmaceutical actives identically
UN Number: Not regulated as a dangerous good for transport internationally
Proper Shipping Name: Sofosbuvir, pharmaceutical ingredient
Hazard Class: Non-hazardous for air, road, and sea
Packing Group: Not applicable
Special Precautions: Keep in original packaging during transport; guard against moisture and light
Transport Labels: None required; laboratory packaging mark as "Research Chemical – Not for Human Consumption" if required
Inventory Status: Not included on bulk chemical inventories (TSCA, EINECS, etc.) due to pharmaceutical nature
OSHA Hazard Communication: Active ingredient not classified as hazardous but safe handling practices remain necessary in line with pharmaceutical GMP
WHMIS Classification: Not controlled/regulated
SARA Title III: Not subject to SARA Title III Section 313 reporting
Other Regulations: Rx active—a controlled pharmaceutical in many jurisdictions; specific local handling, recordkeeping, and environmental rules apply
Labelling Requirements: Must be clearly labeled with product and hazard information, signal words, and manufacturer/supplier details as per local authority rules
