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Product Name: Sisomicin Sulfate
Chemical Name: Sisomicin disulfate salt
Synonyms: Antibiotic Siso sulfate
Recommended Use: Pharmaceutical ingredient, research compound
Manufacturer: Manufacturer address and emergency contact
CAS Number: 3455-21-6
UN Number: Not regulated
EC Number: Not assigned
Molecular Formula: C19H37N5O7 • H2SO4
Molecular Weight: ~573.62 g/mol
Identifying Features: White to off-white powder, no distinct odor
GHS Classification: Eye Irritant Category 2, Skin Sensitizer Category 1
Hazard Statements: Causes serious eye irritation. May cause allergic skin reaction. Harmful if swallowed, inhaled, or absorbed through skin.
Pictograms: Exclamation mark, Health hazard
Signal Word: Warning
Precautionary Statements: Avoid breathing dust. Use protective gloves and eye protection. Wash hands thoroughly after handling. Do not eat, drink, or smoke near the material.
Health Hazards: Risk of allergic reaction among sensitive individuals. Possible nephrotoxic and ototoxic effects with repeated exposure.
Environmental Hazards: May be hazardous to aquatic organisms on basis of antibiotic effect.
Hazardous Decomposition Products: None identified under normal conditions.
Ingredient: Sisomicin Sulfate
Concentration: >98% (by weight)
Chemical Family: Aminoglycoside antibiotic
Impurities: Trace amounts of related antimicrobial compounds and inorganics
Other Components: Not classified as hazardous under OSHA
Additives/Stabilizers: Not added
CAS Number: 3455-21-6
Eye Contact: Rinse with plenty of water for at least 15 minutes, keeping eyelids open. Get medical attention if irritation persists.
Skin Contact: Remove contaminated clothing. Wash skin with soap and water. Call a physician if irritation or allergic reaction develops.
Inhalation: Move person to fresh air. Seek medical advice if symptoms like coughing or difficulty breathing persist.
Ingestion: Rinse mouth with water. Never induce vomiting unless instructed by a medical professional. Seek immediate medical attention if large quantity ingested.
Most Important Symptoms: Redness, itching, rash. Possible respiratory distress in sensitive individuals. Nausea or vomiting after ingestion.
Suitable Extinguishing Media: Use dry chemical, foam, carbon dioxide, or water spray.
Unsuitable Media: High-pressure water streams may spread powder.
Specific Hazards: May form hazardous dust clouds that can ignite.
Protective Equipment for Firefighters: Use self-contained breathing apparatus and full protective suit.
Combustion Products: Emits nitrogen oxides, sulfur oxides, carbon oxides under fire conditions.
Fire Precautions: Avoid inhalation of fire-generated fumes. Move containers from fire area if it can be done safely.
Personal Precautions: Wear gloves, protective eyewear, and dust mask. Ensure adequate ventilation. Avoid contact with skin and eyes.
Spill Cleanup Methods: Carefully sweep up powder without generating dust. Place material in appropriate waste container.
Environmental Precautions: Prevent run-off from entering drains, sewers, or waterways.
Decontamination: Wipe area with damp disposable towels, then thoroughly clean with detergent and water.
Disposal of Contaminated Material: Dispose of as pharmaceutical waste in accordance with regulations.
Emergency Procedures: Notify relevant authorities in case of large spills.
Safe Handling: Use with local exhaust ventilation or in a chemical fume hood. Wear protective gear to minimize exposure.
Hygiene Practices: Wash hands before breaks and after handling. Remove contaminated clothing before eating.
Conditions for Safe Storage: Keep container tightly closed in a dry, cool, and well-ventilated location. Store away from foodstuffs.
Incompatible Substances: Strong oxidizing agents, acids, bases
Storage Temperature: Room temperature recommended (15-30°C)
Packaging Materials: Use original container with secure lid. Label storage container clearly.
Exposure Limits: No occupational exposure limits established for Sisomicin Sulfate.
Engineering Controls: Work in ventilated areas. Use appropriate exhaust systems for handling powders.
Personal Protective Equipment: Safety goggles, chemical-resistant gloves (nitrile or latex), lab coat
Respiratory Protection: Dust respirator or mask under conditions of dust generation.
Other Protection: Emergency shower and eyewash station in workplace.
Environmental Controls: Use procedures to minimize release to the environment.
Appearance: White to slightly off-white powder
Odor: None or faint
Odor Threshold: Not determined
pH (1% Solution in Water): 3.0-5.0
Melting Point: Decomposes before melting
Boiling Point: Not applicable
Flash Point: Not determined
Evaporation Rate: Not applicable
Flammability: Not highly flammable, but dust may form explosive mixture with air
Vapor Pressure: Negligible
Solubility: Soluble in water, slightly soluble in methanol, insoluble in organic solvents
Partition Coefficient (log Pow): Not available
Auto-ignition Temperature: Not determined
Explosive Properties: Not expected
Oxidizing Properties: Not oxidizing
Chemical Stability: Stable under recommended storage conditions.
Reactivity: Not reactive under normal conditions.
Incompatible Materials: Avoid contact with strong oxidizers, strong acids or bases
Conditions to Avoid: Excess moisture, extreme temperatures
Hazardous Decomposition: May yield toxic gases (NOx, SOx, COx) on thermal decomposition.
Polymerization: Not known to occur.
Likely Routes of Exposure: Inhalation, skin and eye contact, ingestion
Acute Toxicity: LD50 for oral, dermal, inhalation not precisely established, but presents risk of irritation and systemic effects
Skin Irritation: Possible irritation or allergic reaction
Eye Injury: Risk of severe irritation
Respiratory Effects: Irritation with prolonged exposure; can cause respiratory sensitization
Chronic Toxicity: Repeated exposure linked to nephrotoxicity and ototoxicity
Sensitization: May cause allergic skin and respiratory reaction
Carcinogenicity: Not classified as carcinogenic by IARC, NTP, or OSHA
Mutagenicity: No evidence reported
Reproductive Effects: Data insufficient; use caution
Aquatic Toxicity: Antibiotics may affect aquatic microorganisms at low concentrations
Terrestrial Toxicity: Effects on soil bacteria not fully characterized
Persistence and Degradability: Not readily biodegradable
Bioaccumulation: Low potential
Mobility in Soil: High solubility in water suggests mobility in groundwater possible
Other Adverse Effects: Potential for antimicrobial resistance development in environmental microorganisms
Precautions: Limit release to environment by careful disposal of unused product and waste
Waste Treatment Methods: Incinerate in authorized facility or dispose as pharmaceutical waste by licensed contractor
Contaminated Packaging: Triple rinse and dispose as hazardous waste
Precautions for Disposal: Do not dispose with general municipal waste or release into environment
Regulatory Requirements: Must comply with local, state, and federal guidelines for antibiotic disposal
UN Number: Not regulated for transport
Transport Hazard Class: Not classified as hazardous for transportation
Packing Group: Not assigned
Shipping Name: Sisomicin Sulfate
Special Precautions for Transport: Protect against physical damage, moisture, and contamination
Environmental Hazards: Not regulated for marine pollutant risk
Transport in Bulk: Not applicable
US TSCA Status: Not listed for commercial use
OSHA Hazardous Chemical: Regulated occupational hazard
SARA Title III Sections 302, 304, 313: Not listed
California Proposition 65: Not listed as causing reproductive harm or cancer
WHMIS Classification (Canada): D2B: Toxic Material Causing Other Toxic Effects
EU Regulations: Not classified under CLP for commercial use; observe REACH registration for development stages
Other Regulatory Considerations: Use subject to pharmaceutical handling guidelines and local health authority restrictions
Labeling Requirements: Must include hazard pictograms and signal word; adhere to national and local labeling standards
