© 2026 Sinochem Nanjing Corporation,
All Right Reserved
Product Name: Simethicone
Synonyms: Polydimethylsiloxane with silicon dioxide, Antifoam AF
CAS Number: 8050-81-5
Recommended Uses: Defoaming agent in pharmaceuticals, relief of bloating and discomfort caused by gas
Manufacturer Contact: Check product label for supplier name, address, and emergency phone number
Emergency Overview: Clear, viscous, odorless liquid or emulsion; non-flammable; non-toxic in usual handling
Physical Hazards: Slippery when spilled
Health Hazards: Not generally considered hazardous in normal use; ingestion, eye or prolonged skin contact may cause mild irritation
Environmental Hazards: Non-toxic to aquatic organisms at typical concentrations found in the environment
GHS Label Elements: No pictogram or signal word required; considered non-hazardous
Chemical Name: Simethicone
Chemical Family: Polydimethylsiloxane and silica
Content: Simethicone (polydimethylsiloxane 88–92%, silica 8–12%)
Impurities: Minor content of water and trace process by-products
CAS Number(s): 8050-81-5
Eye Contact: Rinse cautiously with water for several minutes; remove contact lenses if present and easy to do; seek medical attention if irritation persists
Skin Contact: Wash affected area with soap and water; seek medical advice if irritation occurs
Ingestion: Rinse mouth with water; do not induce vomiting; drink water to dilute; medical assistance may be helpful if large quantities are swallowed
Inhalation: Unlikely route of exposure due to viscosity; move to fresh air if symptoms develop; seek attention if discomfort remains
Note to Physicians: Provide symptomatic and supportive treatment as required
Suitable Extinguishing Media: Water spray, dry powder, carbon dioxide, foam
Unsuitable Media: Do not use water jet directly on product; risk of spreading slippery liquid
Hazardous Decomposition: Oxides of carbon, silicon dioxide, formaldehyde at high temperatures
Special Protective Equipment: Firefighters should use self-contained breathing apparatus; standard protective clothing advised
Special Procedures: Cool containers exposed to fire with water spray; prevent run-off from entering drains and watercourses
Personal Precautions: Use gloves and eye protection to avoid contact; area can become slippery
Environmental Precautions: Prevent further leakage or spillage if safe to do so; avoid discharge into drains, surface and ground water
Cleanup Methods: Absorb with suitable inert materials such as sand or earth; collect spilled material into labeled containers for disposal; wash spill area with water and detergent
Notification Procedures: Report substantial release to authorities if required by local regulations
Handling: Avoid prolonged contact with eyes and skin; wear protective equipment as indicated; clean up spills quickly to prevent falls
Storage Conditions: Store in tightly closed containers; keep in a dry, cool, and well-ventilated area; protect from freezing and direct sunlight
Incompatibilities: Strong oxidizers such as chlorine, hydrogen peroxide; acids
Additional Advice: Use only within expiration period as marked on packaging
Permissible Exposure Limits: No occupational exposure limits established for simethicone
Engineering Controls: Use in well-ventilated area; local exhaust may be helpful in industrial settings
Personal Protective Equipment: Safety goggles or glasses, gloves made from nitrile or rubber, standard protective clothing
Hygiene Measures: Wash hands after handling; do not eat, drink, or smoke during use
Appearance: Colorless, odorless liquid of medium viscosity
Odor: Odorless
pH: Neutral
Boiling Point: >100°C
Melting/Freezing Point: Not applicable (remains liquid at typical storage conditions)
Flash Point: >300°C
Solubility: Insoluble in water; disperses in many organic solvents
Vapor Pressure: Extremely low
Density: 0.96–0.98 g/cm³ (20°C)
Viscosity: Varies depending on formulation
Chemical Stability: Stable under normal storage and use conditions
Reactive Hazards: None identified in intended applications
Conditions to Avoid: Excessive heat, strong oxidizers, acid, direct sunlight
Hazardous Decomposition: Formaldehyde, silicon oxides, carbon oxides can release at elevated temperatures, especially in fire
Polymerization: Will not occur
Acute Toxicity: Not considered toxic by ingestion, inhalation, or skin contact; estimated oral LD50 (rat) > 5000 mg/kg
Skin Corrosion/Irritation: Mild and reversible if it occurs
Eye Damage/Irritation: Possible mild, transient irritation
Respiratory Effects: Unlikely under normal use; mists may cause temporary discomfort
Sensitization: Not a sensitizer
Carcinogenicity: Not listed as a carcinogen by IARC, OSHA, or NTP
Mutagenicity: Not known to cause genetic defects
Other Information: No known reproductive or developmental toxicity
Aquatic Toxicity: Low toxicity to aquatic life based on available data
Persistence and Degradability: Siloxane backbone resists biodegradation, but environmental risk is minimal at use levels
Bioaccumulation: Limited potential due to molecular size and stability
Mobility in Soil: Low mobility in soil and sediment; tends to adsorb
Other Adverse Effects: Not expected to have significant long-term impact on environment under approved use scenarios
Waste Disposal Method: Treat as non-hazardous waste; dispose according to local regulations; incineration or landfill in compliance with all applicable waste disposal laws
Packaging Disposal: Triple rinse empty containers before recycling or disposal; avoid release to environment
Special Precautions: Prevent any release of product into surface water, sewers or soil.
UN Number: Not regulated for transport
UN Proper Shipping Name: Not classified as dangerous goods
Transport Hazard Class: Not applicable
Packing Group: Not applicable
Environmental Hazards: None
Special Precautions for User: Prevent container damage during transit; use in line with temperature and handling recommendations
Safety, Health, Environmental Regulations: Not classified as a hazardous substance under GHS; Simethicone appears on many national and international inventories such as TSCA (USA), AICS (Australia), DSL (Canada), EINECS/ELINCS (EU), ENCS (Japan)
Labelling: Not subject to hazard labeling under OSHA Hazard Communication Standard
Other Regulatory Status: Approved as pharmaceutical excipient or active ingredient by relevant authorities in the US, EU, Canada, and many other regions
