© 2026 Sinochem Nanjing Corporation,
All Right Reserved
Product Name: Selumetinib
SYNONYMS: AZD6244, ARRY-142886
Manufacturer: AstraZeneca
Recommended Use: Research and pharmaceutical applications as a MEK inhibitor
Emergency Number: Local Poison Control Center or Health & Safety Department contact provided by the distributor
Product Description: Fine, white to off-white powder, typically supplied in sealed vials for laboratory or clinical use
CAS Number: 606143-52-6
UN Number: Not classified as hazardous for transport under most regulatory schemes
Contact Information: Provided on order documentation or site safety office contact list
Hazard Class: Not classified as a hazardous substance under GHS guidelines for laboratory quantities, though manufacturer advises handling with care
Routes of Exposure: Inhalation, ingestion, skin and eye contact
Health Hazards: May cause respiratory irritation, skin and eye irritation; harmful if swallowed; potential reproductive toxicity noted in animal studies
Label Elements: Warning pictogram and wording for research chemical
Acute Effects: Throat, skin, or eye irritation, headache, dizziness if inhaled as dust
Chronic Effects: Laboratory animal tests indicate potential carcinogenic, mutagenic, and reproductive risk; no long-term human studies reported
Precautionary Statements: Avoid breathing dust, use personal protective equipment, wash hands after handling
Chemical Name: Selumetinib
Chemical Formula: C17H15BrClFN4O3
Chemical Family: Triazine derivative
Purity: Typically >98% for laboratory-stocked material
Impurities: None with known health effects at research-relevant levels
Chemical Structure: Detailed description available from supplier’s chemical registry
Inhalation: Move to fresh air, seek medical attention for any signs of irritation, shortness of breath, or persistent symptoms
Skin Contact: Immediately remove contaminated clothing and wash affected area thoroughly with soap and water; consult with a medical professional for irritation or persistent rash
Eye Contact: Rinse eyes with plenty of water for at least 15 minutes, lifting eyelids occasionally; seek medical attention if redness or discomfort persists
Ingestion: Rinse mouth, do not induce vomiting unless told by medical professional; contact poison center or emergency services for further guidance
Suspected Overexposure: Supervised medical observation recommended for significant exposure, as no antidote exists
Suitable Extinguishing Media: Dry chemical powder, carbon dioxide, foam, or water spray
Unsuitable Media: Avoid streams of water that may spread material
Hazardous Combustion Products: Emits toxic fumes of hydrogen chloride, bromide, fluorides, carbon oxides, nitrogen oxides on burning
Protective Equipment: Full protective gear for firefighters, including positive pressure self-contained breathing apparatus
Special Procedures: Cool containers exposed to fire with water spray; prevent runoff to drains or sewers
Personal Precautions: Use gloves, safety glasses, appropriate lab coat; restrict access to spill area
Environmental Precautions: Prevent further leakage or spillage if safe to do so, avoid release to the environment, keep out of drains and surface water
Cleanup Procedures: Gently collect spilled powder using dampened disposable cloth or absorbent; place in sealed chemical waste container; ventilate area and clean surfaces with confirmed deactivating detergent
Disposal: Handle as hazardous pharmaceutical waste per institutional and local guidelines
Handling: Wear gloves, protective eyewear, mask or respirator; perform open transfers in fume hood or well-ventilated area; avoid breathing dust
Storage Conditions: Keep container tightly closed and protected from moisture; store at 2-8°C; keep away from sources of ignition; segregate from strong acids, bases, and oxidizers
Container Requirements: Use original packaging or compatible sealed containers marked with chemical name and hazard label
Hygiene Practices: Wash hands thoroughly after use; do not eat, drink, or smoke in handling areas
Occupational Exposure Limits: No specific exposure limits have been established; treat as a potent pharmaceutical agent
Engineering Controls: Local exhaust ventilation, fume hood, closed handling systems for bulk manipulation
Respiratory Protection: Utilize NIOSH-approved respirator if dust is generated or in case of inadequate ventilation
Skin Protection: Chemically resistant gloves, laboratory coat or suit
Eye Protection: Safety glasses with side shields, splash-proof goggles for bulk transfer
Workplace Controls: Access restricted to trained personnel, reinforce chemical hygiene protocols
Appearance: White to off-white crystalline powder
Odor: Odorless
Melting Point: 148°C to 152°C (literature value)
Boiling Point: Data not available due to potential decomposition before boiling
Solubility: Slightly soluble in water; soluble in DMSO, ethanol, methanol
Vapor Pressure: Not applicable for solid
Flash Point: Not established for this material
pH: Not determined (insoluble in water)
Molecular Weight: 457.68 g/mol
Density: Not established scientifically for lab use
Chemical Stability: Stable under recommended conditions of storage and handling
Conditions to Avoid: Exposure to light, moisture, excessive heat, strong acids or bases, and oxidizing agents
Incompatible Materials: Strong oxidizers, reducing agents, strong bases, acids
Hazardous Decomposition Products: Thermally decomposes to release toxic and irritating vapors including carbon oxides, hydrogen halides, and nitrogen oxides
Reactivity: No dangerous reactions expected under recommended conditions of use
Acute Toxicity: Not fully evaluated in humans, studies in animals suggest LD50 (oral, rat) above 2000 mg/kg
Skin and Eye Contact: May cause mild irritation; no severe corrosive effects in animal models
Inhalation: Dust may cause irritation of respiratory tract
Chronic Effects: Evidence of teratogenicity and reproductive toxicity in animal studies
Carcinogenicity: Not listed as a known human carcinogen by IARC, NTP, OSHA
Other Data: Long-term effects not established for occupational exposure
Ecotoxicity: Data limited; related compounds suggest potential aquatic toxicity at high concentrations
Persistence and Degradability: Not readily biodegradable based on chemical structure
Bioaccumulative Potential: Predicted low mobility in soil, moderate potential for bioaccumulation in aquatic species
Mobility in Soil: Expected to be adsorbed in sediment and organic matter
Other Adverse Effects: Avoid uncontrolled release to environment
Disposal Methods: Dispose of as pharmacy or laboratory hazardous chemical waste; follow institutional guidelines and local, state, or national regulations
Container Disposal: Triple rinse if necessary, mark as hazardous, return to chemical waste collection
Precautions: Never discard in regular trash, down sink, or into general waste streams
UN Number: Not regulated for transport in small quantities
ADR/RID, DOT, IATA, IMDG: Not classified as dangerous goods for these regulations
Packing Group: Not applicable
Special Precautions: Package securely to prevent breakage and spillage, include hazard label if above threshold amounts
OSHA Status: Not specifically regulated
SARA Title III Section 313: Not subject to reporting requirements
TSCA Listing: For research and development only, not listed for commercial manufacture
EU Regulation: Research chemical only, not for human use under REACH; may qualify for small volume exemptions
Other Relevant Laws: Subject to safe handling, waste, and worker protection rules—local, state, or country-specific pharmaceutical controls may apply
