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Product Name: Sarafloxacin Hydrochloride
Chemical Formula: C20H18F2N4O3•HCl
Synonyms: N-(6-fluoro-1,4-dihydro-7-(1-piperazinyl)-4-oxoquinoline-3-carboxylic acid hydrochloride, Saraflox HCl
CAS Number: 91296-87-6
Manufacturer Information: Supplier’s name and emergency contact number needed from packaging or producer.
Recommended Use: Veterinary antibiotic, research chemical, pharmaceutical raw material. Not for human use.
Restrictions on Use: Restricted to qualified personnel and designated laboratories. Adherence to safety protocols is required during use and disposal.
Classification: Acute Toxicity (Oral), Category 4; Eye Irritation, Category 2A; Skin Sensitization, Category 1
Signal Word: Warning
Hazard Statements: Harmful if swallowed. Causes serious eye irritation. May cause an allergic skin reaction. May cause respiratory irritation.
Pictograms: Exclamation mark, Health hazard
Precautionary Statements: Avoid breathing dust or powder. Wash hands thoroughly after handling. Wear protective gloves, clothing, eye protection, and face protection. Do not eat, drink, or smoke when using this product.
Other Hazards: Dust may form explosive mixtures with air. Environmental hazard for aquatic organisms.
Chemical Name: Sarafloxacin Hydrochloride
CAS Number: 91296-87-6
Concentration: ≥98% as active ingredient
Impurities: Residual solvents or related compounds under regulatory thresholds.
Additives: None known in pure, analytical grade form.
Inhalation: Move person to fresh air. Seek medical attention if symptoms appear, such as coughing, shortness of breath, or dizziness.
Skin Contact: Remove contaminated clothing. Rinse skin with plenty of water and soap for several minutes. Seek medical advice if irritation or sensitivity occurs.
Eye Contact: Immediately flush eyes with running water for a minimum of 15 minutes, lifting eyelids occasionally. Remove contact lenses if present. Medical attention recommended.
Ingestion: Rinse mouth with water; do not induce vomiting. Seek immediate medical attention if feeling unwell, ingestion can be harmful with risk of gastrointestinal symptoms.
Note to Physician: Provide symptomatic and supportive care. Monitor for allergic or toxic reactions.
Suitable Extinguishing Media: Use dry chemical powder, water spray, foam, or carbon dioxide.
Specific Hazards: Emits hazardous fumes including nitrogen oxides, carbon monoxide, hydrogen chloride, and fluorine compounds when burned.
Firefighting Instructions: Use self-contained breathing apparatus and full protective gear. Prevent fire extinguishing water from entering drains.
Unusual Fire & Explosion Hazards: Dust can disperse and form explosive mixture with air under certain conditions.
Protective Equipment: Wear positive pressure breathing apparatus.
Personal Precautions: Eliminate ignition sources. Ventilate area. Wear appropriate PPE including dust mask, gloves, and goggles.
Environmental Precautions: Prevent release into sewers, surface waters, and soil. Notify authorities if significant spill occurs.
Containment and Cleanup: Use non-sparking tools to collect spilled material. Dampen powder to minimize dust formation. Place in a suitable container for disposal. Clean residue with water and detergent.
Disposal: Dispose according to local, state, and national regulations.
Handling: Avoid contact with skin, eyes, and clothing. Avoid creating dust. Use procedures that minimize exposure including closed processes, local exhaust ventilation, and protective equipment.
Storage: Store in a tightly closed container, in a cool, dry, well-ventilated place away from sources of ignition and incompatible materials such as strong acids, strong bases, and oxidizers.
Special Precautions: Keep away from food and drink. Label containers clearly. Only trained and authorized personnel should have access.
Engineering Controls: Use local exhaust ventilation and process enclosures to keep airborne levels below exposure limits. Provide eyewash and safety showers.
Respiratory Protection: Use NIOSH-approved dust masks or respirators if airborne exposure limits are exceeded.
Eye and Face Protection: Safety goggles or face shields required; risk of eye irritation.
Skin Protection: Chemical-resistant gloves, long sleeves, and lab coats.
Body Protection: Suitable clothing to prevent skin exposure.
Hygiene Measures: Wash hands after handling. No eating, drinking, or smoking in work areas.
Occupational Exposure Limits: No occupational exposure limits established for Sarafloxacin Hydrochloride. Handle as potentially hazardous material.
Appearance: White to off-white crystalline powder
Odor: Odorless
Odor Threshold: Not determined
pH: 3.5-5.5 (1% solution in water)
Melting Point/Freezing Point: 266-268°C
Boiling Point/Range: Not available
Flash Point: Not applicable
Evaporation Rate: Not applicable
Flammability (solid, gas): Combustible dust
Upper/Lower Flammability or Explosive Limits: Not available
Vapor Pressure: Negligible at ambient temperature
Vapor Density: Not applicable
Solubility(ies): Soluble in water, slightly soluble in ethanol
Partition Coefficient (n-octanol/water): Log P (oct/water): -0.39
Auto-ignition Temperature: Not determined
Decomposition Temperature: Above 200°C
Viscosity: Not applicable
Chemical Stability: Stable under recommended storage conditions.
Reactivity: Non-reactive under normal use and storage.
Hazardous Reactions: May react with strong oxidizers, strong acids, or bases.
Conditions to Avoid: High temperatures, incompatible materials, direct sunlight, humidity.
Incompatible Materials: Strong oxidizing agents, strong acids, bases.
Hazardous Decomposition Products: Produces toxic fumes including nitrogen oxides, hydrogen chloride, fluoride compounds, and carbon monoxide.
Routes of Exposure: Inhalation, ingestion, skin, and eye contact.
Acute Toxicity: LD50 Oral (rat): 610 mg/kg. Symptoms may include nausea, vomiting, diarrhea, headache, and drowsiness.
Skin Corrosion/Irritation: May cause irritation and reddening.
Eye Damage/Irritation: Causes moderate to severe irritation.
Respiratory Sensitization: Risk of allergic reactions or asthma symptoms with repeated exposure.
Skin Sensitization: May cause allergic skin reactions.
Carcinogenicity: Not listed by NTP, IARC, OSHA.
Germ Cell Mutagenicity: No evidence in standard tests, but studies in animals are limited.
Reproductive Toxicity: Animal studies indicate possible reproductive toxicity at high doses.
Target Organ Effects: Prolonged exposure can affect kidneys, liver, and central nervous system.
Other Effects: Long-term exposure may lead to bacterial resistance in environmental settings.
Ecotoxicity: Toxic to aquatic organisms. May cause long-term adverse effects in the aquatic environment.
Persistence and Degradability: Moderate persistence, not readily biodegradable. Degradation products can be harmful.
Bioaccumulative Potential: Low potential for bioaccumulation (Log Kow: -0.39).
Mobility in Soil: Moderate mobility; can leach to groundwater.
Other Adverse Effects: Can induce bacterial resistance. Impact on microbial activity in wastewater treatment plants.
Waste Treatment Methods: Consult federal, state, and local health and environmental regulations. Incinerate at approved facility using pollution control devices or dispose of under hazardous waste guidelines.
Contaminated Packaging: Treat empty containers as hazardous. Use triple-rinsing method before disposal.
Special Instructions: Do not discharge into waterways, drains, or soil. Consider environmental impact, including potential for antibiotic resistance development.
UN Number: Not assigned for this substance
UN Proper Shipping Name: Not regulated for transport as dangerous good
Transport Hazard Class: Not classified for transport
Packing Group: Not applicable
Environmental Hazards: Presents a potential hazard for aquatic life if released
Special Precautions: Keep tightly sealed and upright during transport. Secure containers to avoid spills.
Transport in Bulk (Annex II of MARPOL 73/78): Not applicable
US Federal Regulations: Not listed as hazardous under OSHA or TSCA. Not regulated as a controlled substance.
EPA: Not regulated under CERCLA, SARA Title III, or RCRA as a hazardous waste.
International Regulations: Not specifically classified by the EU or IARC, but subject to REACH registration if imported or manufactured in the EU in quantities above one metric ton per year.
Other National Regulations: Subject to veterinary pharmaceutical regulations in multiple jurisdictions. Not approved for use in food-producing animals in several countries.
California Proposition 65: Not listed.
Labelling Requirements: Appropriate hazard statements, pictograms, and relevant safety precautions must appear on containers and safety documentation.
