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Product Name: Sancycline Hydrochloride
Chemical Family: Tetracycline antibiotic
Common Synonyms: 4-Dedimethylaminotetracycline hydrochloride
Molecular Formula: C20H21N3O7·HCl
Molecular Weight: 451.86 g/mol
Recommended Use: Research and pharmaceutical manufacturing
Supplier Details: [Insert manufacturer's name, address, and contact information]
Emergency Contact: [Insert emergency phone number]
GHS Classification: Acute Toxicity (Oral, Category 4), Eye irritation (Category 2A), Skin irritation (Category 2)
Signal Word: Warning
Hazard Statements: Harmful if swallowed. Causes serious eye irritation. Causes skin irritation.
Precautionary Statements: Avoid contact with skin, eyes, and clothing. Wear protective gloves and eye protection. Wash hands thoroughly after handling.
Pictograms: Exclamation mark
Potential Health Effects: May cause gastrointestinal irritation, allergic reactions, or photosensitivity.
Routes of Exposure: Inhalation, ingestion, skin, eye contact
Chemical Name: Sancycline Hydrochloride
CAS Number: 2058-46-0
Concentration: ≥98% (pure form, may vary by supplier)
Impurities: Trace residual solvents or byproducts possible below regulatory thresholds
Other Components: No significant non-active components present
Inhalation: Move the affected person to fresh air. If breathing becomes difficult, seek medical attention immediately.
Skin Contact: Remove contaminated clothing and wash skin thoroughly with plenty of soap and water. Seek medical advice if irritation persists.
Eye Contact: Rinse eyes gently with running water for at least 15 minutes, lifting upper and lower eyelids occasionally. Get medical attention if irritation continues.
Ingestion: Rinse mouth with water. Do not induce vomiting. Get medical help or call a poison center right away.
Most Important Symptoms: Redness, irritation, possible allergic reaction; symptoms can include upset stomach, rash, photodermatitis, or respiratory discomfort.
Notes to Physician: Treat symptomatically and provide supportive care.
Suitable Extinguishing Media: Water spray, carbon dioxide, dry chemical, or foam.
Unsuitable Media: Direct water jet (risk of chemical spread).
Specific Hazards: May liberate toxic fumes, including nitrogen oxides, hydrogen chloride, and carbon monoxide if involved in a fire.
Protective Equipment: Firefighters should wear self-contained breathing apparatus and full protective clothing.
Advice for Firefighters: Prevent runoff from entering drains or waterways. Apply standard chemical firefighting procedures.
Thermal Decomposition Products: Decomposition releases hazardous gases such as hydrocarbons, nitrogen oxides, and HCl.
Personal Precautions: Wear suitable gloves, protective eyewear, and lab coat. Prevent skin and eye contact.
Environmental Precautions: Prevent release into drains, sewers, and waterways. Use barriers or absorbent materials for spills.
Containment and Cleanup: Sprinkle spill with inert absorbent (e.g., vermiculite, sand), scoop up carefully, and place in a chemical waste container for disposal. Ventilate area. Wash spill site after cleanup.
Methods of Disposal: Refer to local regulations for chemical waste disposal, using specialized incineration or landfill as required.
Handling Precautions: Use in a well-ventilated area, minimizing dust and direct contact. Avoid inhaling powder or vapors. Do not eat, drink or smoke in working area.
Storage Conditions: Store in a tightly sealed container in a cool, dry place, away from incompatible substances (strong acids, bases, oxidizers). Protect from light and moisture.
Specific Uses: Restricted to laboratory and research applications by trained personnel.
Incompatibilities: Avoid contact with oxidizing agents and acids.
Safe Transfer: Use sealed systems or dust extraction during transfers.
Occupational Exposure Limits: No occupational exposure limit assigned; minimize exposure by engineering controls.
Engineering Controls: Use fume hoods, local exhaust ventilation, or enclosed handling systems.
Personal Protective Equipment (PPE): Chemical-resistant gloves (nitrile or latex), protective safety goggles, lab coat or coveralls, respiratory protection if dust/aerosol is generated.
Hygiene Measures: Wash thoroughly after handling. Remove contaminated clothing and wash before reuse.
Environmental Controls: Prevent escape during handling and from waste streams; implement waste trapping where required.
Specific Monitoring: Airborne concentrations should be kept as low as reasonably achievable.
Appearance: Yellow to pale orange crystalline powder
Odor: Odorless or slight characteristic
pH: 2-4 (aqueous solution)
Melting Point: Decomposes above 200°C
Boiling Point: Not applicable (decomposes before boiling)
Solubility: Soluble in water, slightly soluble in ethanol
Vapor Pressure: Negligible under ambient conditions
Relative Density: 1.45–1.55 g/cm³
Partition Coefficient (Log Pow): Not available
Viscosity: Not applicable
Other Properties: Sensitive to heat and light; degrades over time by hydrolysis
Chemical Stability: Typically stable when stored as recommended; light and moisture can cause degradation.
Reactivity: Not reactive under normal laboratory or storage conditions.
Conditions to Avoid: High temperatures, direct sunlight, humid environments; exposure to acids or bases.
Incompatible Materials: Oxidizers, strong acids, strong bases.
Hazardous Decomposition Products: Nitrogen oxides, hydrogen chloride, carbon monoxide, and other toxic fumes on combustion or decomposition.
Acute Toxicity: Oral LD50 (rat) not fully established; estimated >500 mg/kg; moderate acute hazard.
Skin Corrosion/Irritation: Causes irritation with prolonged or repeated exposure.
Serious Eye Damage/Irritation: Causes eye irritation; may damage corneal tissue if not rinsed promptly.
Respiratory or Skin Sensitization: May cause allergic reactions or photosensitivity in some individuals.
Germ Cell Mutagenicity: No definitive data; generally not considered genotoxic at low doses.
Carcinogenicity: Not listed as a known carcinogen by IARC, OSHA, or NTP.
Reproductive Toxicity: Effects on fetal development noted in animal studies; care advised for pregnant individuals.
STOT-Single/Repeated Exposure: High exposure may affect kidney or liver.
Other Information: May cause gastrointestinal upset, photosensitivity, allergic reactions.
Ecotoxicity: Harmful to aquatic organisms. Use of containment reduces release to environment.
Persistence and Degradability: Moderately persistent; may degrade slowly under aerobic and anaerobic conditions.
Bioaccumulation Potential: Low; expected to have limited potential for bioaccumulation.
Mobility in Soil: Moderate water solubility; possible leaching in moist environments; may bind to soil particles.
Other Adverse Effects: Large spills could disturb microbial populations in water and soil.
Waste Treatment Methods: Incinerate or landfill as hazardous pharmaceutical waste in accordance with federal, state, and local regulations.
Contaminated Packaging: Clean before reuse or dispose as regulated chemical waste.
Precautions: Do not allow material or rinsates to enter drains, sewers, or watercourses.
Special Instructions: Coordinate with licensed chemical waste disposal company.
UN Number: Not classified as a dangerous good for transport by road, air, or sea under UN Recommendations.
UN Proper Shipping Name: Not regulated.
Transport Hazard Class: Not applicable.
Packing Group: Not assigned.
Special Precautions: Keep sealed and protected from impact, moisture, and light throughout transport.
Transport in Bulk: Not intended for bulk transport.
Other Transport Information: Follow good laboratory and shipping practices.
Safety, Health, and Environmental Regulations: Subject to chemical hygiene and safety standards under OSHA Laboratory Standard.
TSCA Inventory: Not listed for commercial use.
SARA Title III: Not classified.
California Proposition 65: Substance not currently listed.
Other Regulatory Lists: Not included on EU REACH candidate list; review local regulations for country-specific status.
Labelling Requirements: Proper labeling required for laboratory and transportation activities.
Worker Protection: Use consistent with institutional chemical safety protocols; training in handling hazardous chemicals recommended.
