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Product Name: Sacubitril Sodium
Chemical Name: sodium;3-[[1-([2-(dimethylamino)acetyl]-2-oxo-2,3-dihydro-1H-benzimidazol-5-yl)amino]methyl]-4-(ethoxycarbonyl)benzoate
CAS Number: 149709-62-6
Synonyms: LBQ657, AHU377
Manufacturer: Provided by the formularies or supplier labeling
Recommended Use: Pharmaceutical intermediate for antihypertensive medication, research chemical
Restrictions on Use: Not for food, drug, cosmetic or household use
Emergency Contact: Refer to institutional emergency numbers or the local authorities for guidance during mishaps involving this material
Classification: May cause eye irritation, could provoke skin sensitivity, inhalation of dust possible hazard to respiratory tract
GHS Label Elements: Hazard statements – Harmful if swallowed, contact with eyes or skin can result in temporary irritation
Pictograms: Exclamation mark, health hazard symbol
Signal Word: Warning
Hazard Statements: Possible allergic skin reaction, inhalation may cause coughing or shortness of breath, environmental hazard if introduced in waterways
Precautionary Statements: Avoid contact with eyes and skin, use suitable PPE, avoid inhalation of particulates
Chemical Identity: Sacubitril Sodium
CAS Number: 149709-62-6
Concentration: >98% by weight (If in lab-grade form)
Impurities: Minor traces of related benzimidazole intermediates possible
Other Components: Small percentages of moisture or powder processing aids
Eye Contact: Rinse eyes cautiously with water for 15 minutes, remove contact lenses if present and easy, seek immediate medical attention for persistent irritation
Skin Contact: Remove contaminated clothing, wash skin thoroughly with soap and plenty of water, get medical advice if skin irritation occurs
Inhalation: Move person to fresh air, support breathing as needed, provide medical attention if effects such as coughing or difficulty breathing persist
Ingestion: Rinse mouth, avoid inducing vomiting unless directed by medical authorities, seek immediate medical care if discomfort persists
Important Symptoms and Effects: Potential allergic reactions, respiratory discomfort, eye and skin irritation
Immediate Medical Care/Special Treatment: Symptomatic treatment, provide SDS to healthcare providers
Suitable Extinguishing Media: Water spray, alcohol-resistant foam, dry chemical, carbon dioxide
Unsuitable Extinguishing Media: Direct water stream may scatter material
Unusual Fire or Explosion Hazards: Combustion products may include carbon monoxide, carbon dioxide, nitrogen oxides
Special Protective Equipment for Firefighters: Use self-contained breathing apparatus and full protective gear
Hazardous Combustion Products: Irritating or potentially toxic fumes possible in confined spaces
Firefighting Procedures: Prevent wastewater runoff from fire from entering drains and watercourses
Personal Precautions: Wear gloves, protective lab coat, safety goggles, NIOSH-approved particulate mask
Emergency Procedures: Evacuate unnecessary personnel, ventilate affected area properly
Environmental Precautions: Prevent spillage from entering drains, water courses, or soil
Methods for Containment and Cleaning Up: Gather spilled solid material into suitable containers for proper disposal, use damp cloth or HEPA vacuum to clean residues, avoid generating dust
Reference to Other Sections: For disposal see section on Disposal Considerations
Precautions for Safe Handling: Avoid inhalation of dust, practice good laboratory hygiene, keep containers closed when not in use, use with adequate ventilation
Hygiene Measures: Do not eat, drink, or smoke while using chemical, wash hands and face thoroughly after handling
Conditions for Safe Storage: Store in tightly sealed container, in a cool, dry, well-ventilated area, away from sources of heat or ignition
Incompatibilities: Strong oxidizers, acids, and bases should not be stored nearby
Storage Class: Chemical storage – hazardous substance section as guided by institutional policy
Control Parameters: No established occupational exposure limits; minimize dust exposure
Engineering Controls: Handle in chemical fume hood, use local exhaust ventilation if available
Personal Protective Equipment: Safety glasses with side shields, chemical-resistant gloves (nitrile or latex), lab coat or apron, respirator if handling powder or large quantities
Skin Protection: Wear chemical-resistant gloves, minimize direct skin contact
Eye Protection: Protective goggles or face shield for bulk handling
Respiratory Protection: Approved dust/mist respirator for operations likely to cause dust formation
Environmental Control Measures: Prevent chemical contamination of air, soil, and water
Appearance: White to off-white crystalline powder
Odor: Odorless or slight medicinal smell
pH: Not determined in solid form, neutral in solution
Melting Point: Approximately 135–150°C
Boiling Point: No data (solid, decomposes prior to boiling)
Flash Point: Not applicable – decomposes
Solubility: Soluble in water and polar solvents
Vapor Pressure: Not applicable
Partition Coefficient: Not determined
Evaporation Rate: Not relevant for solid compound
Other Physical Data: Molecular weight about 492.53 g/mol, hygroscopic nature possible
Chemical Stability: Stable under normal conditions of use and storage
Conditions to Avoid: Exposure to high temperatures, direct sunlight, moisture
Incompatible Materials: Strong acids, bases, and oxidizing agents
Hazardous Decomposition Products: Nitrogen/ carbon oxides on burning or decomposition
Polymerization: No dangerous reactions expected under normal use
Reactivity: Unreactive under ambient storage, but breakdown may begin with prolonged exposure to moist environment
Acute Toxicity: Data limited; clinical use indicates low acute oral toxicity, possible dust irritation
Routes of Exposure: Inhalation, ingestion, skin, and eye contact
Symptoms: Irritating to eyes, skin, respiratory tract, possible headaches, dizziness, and gastrointestinal upset
Chronic Effects: Repeated or prolonged exposure may cause skin sensitization, allergic response in susceptible individuals
Carcinogenicity: Animal studies have not shown carcinogenic effects; not classified by IARC or EPA
Mutagenicity: In vitro and animal screening tests suggest low mutagenic risk
Reproductive Toxicity: Not fully evaluated, use caution in pregnant or breastfeeding individuals
Other Info: Significant ingestion above therapeutic dose not studied; seek physician guidance for any exposure beyond incidental contact
Ecotoxicity: Limited information available; possible effects on aquatic life not ruled out, avoid release into environment
Persistence and Degradability: Not readily biodegradable, long-term effects in water and soil not determined
Bioaccumulative Potential: Data inconclusive; structure suggests low likelihood of bioaccumulation
Mobility in Soil: Water-soluble, may migrate if spilled on ground
Other Devastating Effects: Introduction to rivers or lakes may disrupt local microbial activity or invertebrates
Best Practices: Prevent uncontrolled release; handle all spills as hazardous to environment
Waste Treatment Methods: Use licensed chemical waste contractor
Treatment of Product: Dispose of in accordance with local, regional, or national regulations for hazardous waste
Contaminated Packaging: Dispose of containers as hazardous chemical waste after thorough cleaning
Other Considerations: Never pour down the drain or dispose with regular trash
Regulatory Requirements: Consult local regulatory agencies for disposal advice specific to your site
UN Number: Not regulated under UN Transport Code
Proper Shipping Name: Non-regulated pharmaceutical material
Transport Hazard Class: Not classified as dangerous for transport
Packing Group: Not applicable
Marine Pollutant: Avoid uncontrolled discharge to sea or inland waterways
Special Precautions for User: Store in original packaging during transit, keep away from food and animal feed, transport under dry, cool conditions
Other Information: Confirm specific shipping requirements with carrier if shipping internationally
Safety, Health and Environmental Regulations: Subject to workplace hazardous substance regulations as a pharmaceutical chemical
Inventory Status: Not listed on major inventories such as TSCA, EINECS, DSL
US Regulations: Subject to OSHA, SARA Title III, may not require labeling under the Hazard Communication Standard if used in final dosage form
EU Regulations: Not classified as dangerous substance under GHS; CLP guidelines may apply in bulk
Other Regulatory Data: Consult national or regional regulations for health, safety, environmental requirements
Labelling Requirements: Provide hazard information and recommended PPE on all primary containers
