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Product Name: S-Naproxen Sodium Chemical Name: (S)-2-(6-methoxy-2-naphthyl)propanoic acid, sodium salt Synonyms: Naproxen sodium, Sodium (S)-Naproxen CAS Number: 26159-34-2 Recommended Use: Pharmaceutical active ingredient, analgesic, anti-inflammatory Manufacturer: Refer to specific supplier information for contact details Emergency Phone Number: Refer to local emergency response
Classification: Acute toxicity (oral), skin irritation, eye irritation, specific target organ toxicity—single exposure Hazard Statements: Harmful if swallowed, causes skin and eye irritation, may cause respiratory tract irritation Precautionary Statements: Avoid breathing dust, wash thoroughly after handling, use protective clothing and eye protection Signal Word: Warning Symbol/Pictograms: Exclamation mark (GHS07) Routes of Exposure: Inhalation, ingestion, skin and eyes
Chemical Identity: S-Naproxen Sodium Concentration: ≥98% Molecular Formula: C14H13NaO3 Impurities: Related naphthyl-propanoic acid derivatives (<2%) Component Hazards: No additional major hazardous components present
Inhalation: Remove to fresh air. Seek medical attention if symptoms persist. Skin Contact: Wash skin with soap and water. Remove contaminated clothing. If irritation develops, consult a physician. Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses if present, continue rinsing. Seek medical advice if irritation persists. Ingestion: Rinse mouth, do not induce vomiting. Get medical attention if unwell. Most Important Symptoms: Irritation, headache, nausea, respiratory discomfort. Note for Physicians: Treat symptomatically, monitor for potential gastrointestinal bleeding or ulcers associated with NSAIDs.
Suitable Extinguishing Media: Water spray, alcohol-resistant foam, dry chemical, carbon dioxide Unsuitable Media: Do not use water jet Hazardous Combustion Products: Carbon monoxide, carbon dioxide, sodium oxides, irritant fumes Protective Equipment: Self-contained breathing apparatus, full protective clothing Fire Fighting Instructions: Move containers from fire area if safe, cool containers with water spray
Personal Precautions: Use respiratory protection, gloves, eye protection Environmental Precautions: Prevent further leakage or spillage, avoid entry into drains or watercourses Methods for Cleanup: Sweep up and place in suitable, closing containers for disposal, avoid creating dust Decontamination: Wash contaminated area with water and detergent Disposal of Collected Material: Follow safe disposal protocol under local regulations
Handling: Avoid contact with skin, eyes, and clothing. Handle in a well-ventilated area. Prevent formation of dust. No eating, drinking, or smoking during handling. Storage Conditions: Store in tightly closed containers, in a cool, dry, and well-ventilated area, away from incompatible substances such as strong acids or oxidizing agents. Incompatible Materials: Strong acids, strong oxidizers Recommended Packaging: Use chemical-resistant packaging
Engineering Controls: Use local exhaust or general ventilation Personal Protective Equipment: - Respiratory Protection: Approved respirators (NIOSH/MSHA or equivalent) - Skin Protection: Chemical resistant gloves (nitrile or neoprene), laboratory coats - Eye Protection: Safety goggles or face shields - Other Protection: Protective footwear, adequate hygiene measures Exposure Limits: No national exposure limits established for S-Naproxen Sodium
Form: Crystalline powder Color: White to off-white Odor: Odorless Melting Point: 250–255°C (decomposes) Solubility: Freely soluble in water; insoluble in organic solvents pH (solution): 8.5–10 (saturated solution) Boiling Point: Not applicable (decomposes before boiling) Flash Point: Not flammable Partition Coefficient (log Kow): 0.23 Relative Density: 1.34 g/cm³ Vapor Pressure: Negligible
Chemical Stability: Stable under recommended storage conditions Possible Hazardous Reactions: No dangerous reactions under normal use Conditions to Avoid: Moisture, heat, direct sunlight Incompatible Materials: Oxidizing agents, acids Hazardous Decomposition Products: Sodium oxides, carbon monoxide, carbon dioxide, other unspecified organics
Acute Toxicity: Oral LD50 in rats estimated at 600–1000 mg/kg Chronic Toxicity: Data suggest possible renal, hepatic, and gastrointestinal effects with long-term exposure Sensitization: Not known to cause skin sensitization Carcinogenicity: Not classified as carcinogen by IARC, NTP, OSHA Mutagenicity: Not shown to induce genetic damage in standard assays Symptoms of Overexposure: Nausea, headache, dizziness, gastrointestinal irritation, ulceration Additional Effects: May exacerbate pre-existing kidney or liver disorders
Ecotoxicity: Toxic to aquatic organisms, potential for long-term adverse effects in the aquatic environment Mobility: Expected low mobility in soil Persistence and Degradability: Not readily biodegradable, persists in the environment Bioaccumulation Potential: Low bioconcentration observed in aquatic species Aquatic Toxicity Data: LC50 (Fish, 96h): 70 mg/L; EC50 (Daphnia, 48h): 60 mg/L Other Effects: Chronic exposure may affect aquatic life behavior and development
Waste Disposal Methods: Dispose through incineration at approved facility or landfill as hazardous chemical waste in line with local, regional, national and international regulations Container Disposal: Empty containers must be triple rinsed and offered for recycling or disposal at an approved site Precautions: Prevent release to environment; do not dispose by sewer Disposal Regulations: Refer to local, state, and federal regulations regarding chemical waste
UN Number: Not classified under UN transport regulations Proper Shipping Name: Not a dangerous good for ADR, IMO, IATA Transport Hazard Class: Not regulated Packing Group: Not applicable Special Precautions: Prevent spillage, avoid inhalation and contact during transport, ensure appropriate labeling
US Regulations: Listed on TSCA, not listed under SARA Title III or CERCLA OSHA Status: Not specifically regulated EU Regulations: Classified according to Regulation (EC) No 1272/2008 (CLP), safety data sheet available Other Regulations: Not listed as a controlled substance under major international conventions Labeling Requirements: Follow GHS standards, include hazard pictograms and statements Workplace Control: Use as a pharmaceutical ingredient only under controlled conditions
