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Product Name: S-Adenosylmethionine P-Toluenesulfonate
Synonyms: SAMe p-toluenesulfonate salt, S-adenosyl-L-methionine tosylate
Recommended Use: Laboratory chemicals, pharmaceutical manufacturing, biochemical research
Manufacturer Information: [Manufacturer Name], [Address], [Contact Number], [Email]
Chemical Formula: C15H24N6O5S2·C7H8O3S
CAS Number: 97540-22-2
Emergency Phone Number: [Local Emergency Number], [International Emergency Number]
Revision Date: [Most Recent Update]
GHS Classification: Not classified as hazardous according to GHS criteria
Potential Health Effects: Irritation to eyes, skin, and respiratory tract with exposure to dust, mild gastrointestinal discomfort if ingested, aggravation for those with sensitivities
Label Elements: No specific pictogram, Signal word: None, Hazard statements: None
Precautionary Statements: Avoid breathing dust, wash hands thoroughly after handling, use personal protective gear if dust generation likely
Chronic Effects: Data on long-term effects limited, handle with standard precautions
OSHA Hazard Communication Standard: Meets requirements for chemical substance communication
Chemical Name: S-Adenosylmethionine P-Toluenesulfonate
Synonyms: S-adenosyl-L-methionine tosylate salt
Percentage: ≥97% by weight
Impurities: Residual moisture, minor related organic impurities below 3%
Other Ingredients: None intentionally added
CAS Number: 97540-22-2
Inhalation: Move to fresh air immediately, monitor for breathing difficulties, seek medical attention for persistent symptoms
Skin Contact: Wash skin thoroughly with soap and water, remove any contaminated clothing, contact a healthcare provider for irritation or allergic reaction
Eye Contact: Rinse cautiously with water for at least 15 minutes, keep eyelids open, remove contact lenses, seek ophthalmologic care for ongoing irritation
Ingestion: Rinse mouth with water, do not induce vomiting, drink water if conscious for dilution, consult a medical professional immediately for large quantities or symptoms
Most Important Symptoms: Mild to moderate irritation, possible digestive discomfort on ingestion, rarely hypersensitivity
Suitable Extinguishing Media: Water spray, foam, dry chemical, carbon dioxide
Unsuitable Extinguishing Media: High-pressure streams may spread powder
Specific Hazards: May emit toxic vapors (sulfur oxides, nitrogen oxides, carbon oxides) under fire conditions
Protective Equipment: Self-contained breathing apparatus (SCBA) with full protective gear
Fire Fighting Instructions: Evacuate downwind, prevent runoff from contaminating local waterways, cool exposed containers
Combustion Products: Carbon monoxide, carbon dioxide, nitrogen oxides, sulfur oxides, possible organic residues
Personal Precautions: Wear approved gloves, goggles, dust mask; avoid breathing dust; evacuate unnecessary personnel
Environmental Precautions: Prevent entry into sewers, groundwater, and surface water
Clean-up Methods: Sweep or vacuum spills into suitable container for disposal, avoid generating dust, wash spill site with water after cleanup
Disposal: Place solid waste in closed containers; dispose according to local waste laws
Decontamination: Use soap and water for surfaces and equipment; ensure thorough ventilation
Handling: Avoid contact with skin, eyes, and clothing; minimize dust generation and accumulation; use local exhaust ventilation in confined spaces, practice good hygiene by washing after handling
Storage Conditions: Store in original tightly closed container, in a cool, dry, and well-ventilated place; protect from moisture, light, and incompatible substances; keep away from food and beverages
Incompatible Materials: Strong oxidizers, strong acids, strong bases, and reducing agents
Special Provisions: Segregate from incompatible chemicals, label all secondary containers
Control Parameters: No established occupational exposure limits (OSHA, NIOSH, ACGIH)
Engineering Controls: Use fume hood or local exhaust to minimize dust levels, ensure adequate general ventilation
Personal Protective Equipment: Nitrile gloves, safety goggles, laboratory coat, dust mask or respirator if dust expected, closed-toe shoes
Hygiene Measures: Wash hands after use, remove contaminated clothing, keep work area clean
Environmental Controls: Prevent powder release to outdoors, restrict storage near water systems
Appearance: White to off-white powder
Odor: Practically odorless
Odor Threshold: Not determined
pH: 1.2 to 2.0 (1% aqueous solution)
Melting Point/Freezing Point: Decomposes before melting
Boiling Point: Not applicable
Flash Point: Not applicable (non-volatile powder)
Evaporation Rate: Not applicable
Flammability: Not flammable
Vapor Pressure: Not applicable
Vapor Density: Not applicable
Relative Density: 1.3–1.4 g/cm³
Solubility: Soluble in water, slightly soluble in methanol, insoluble in organic solvents
Partition Coefficient (n-octanol/water): Not determined
Autoignition Temperature: Not self-igniting
Decomposition Temperature: Over 200°C
Viscosity: Not applicable
Chemical Stability: Stable under recommended storage conditions
Possibility of Hazardous Reactions: None known under normal conditions, avoid incompatible materials
Conditions to Avoid: Moisture, heat, direct sunlight, open flame, static discharge
Incompatible Materials: Strong acids, bases, oxidizers, reducing agents
Hazardous Decomposition Products: Sulfur oxides, nitrogen oxides, carbon oxides, other toxic fumes on thermal decomposition
Acute Toxicity: Low oral and dermal toxicity expected, information on inhalation toxicity limited
LD50 (Oral, Rat): Not established; structurally similar compounds show very low toxicity
Skin Corrosion/Irritation: Mild irritation in sensitive individuals, especially on prolonged contact
Serious Eye Damage/Irritation: May cause mild to moderate discomfort if contact occurs
Respiratory Sensitization: Dust may aggravate asthma or allergies in predisposed individuals
Germ Cell Mutagenicity: Not classified
Carcinogenicity: No evidence in literature or regulatory lists
Reproductive Toxicity: No known effects on fertility or development
Specific Target Organ Toxicity: None identified with typical workplace exposure
Symptoms of Exposure: Irritation to respiratory tract, eyes, skin; digestive distress if large amounts consumed
Ecotoxicity: No data for aquatic or terrestrial toxicity; structurally similar compounds display low environmental hazard
Persistence and Degradability: Expected to degrade slowly, stable under normal environmental conditions
Bioaccumulative Potential: Not anticipated to bioaccumulate due to high water solubility and metabolic pathways
Mobility in Soil: High mobility if released; material is water soluble and may spread in aqueous environments
Other Adverse Effects: Low risk; avoid intentional release into the environment or waterways
Waste Treatment Methods: Treat as laboratory chemical waste; incinerate or land-fill according to local, regional, and national regulations
Uncontaminated Product: Can be reused or reclaimed where permitted; return to supplier whenever possible
Contaminated Packaging: Dispose as hazardous waste, rinse containers thoroughly before recycling or disposal
Special Precautions: Prevent waste from entering drains, water courses, or soil
UN Number: Not regulated for ground, air, or sea transport
Proper Shipping Name: Not classified as dangerous goods
Transport Hazard Class: Not applicable
Packing Group: Not applicable
Environmental Hazards: Avoid spillage into waterways, not an aquatic hazard under normal shipping conditions
Special Precautions for User: Keep in tightly closed container, minimize movement during transport to prevent physical damage
Bulk Transport: Not subject to MARPOL, IBC Code, or special provisions
TSCA (US): Listed or meets requirements for R&D substances
DSL/NDSL (Canada): Not listed, check with authorities for exemptions under research status
EU REACH: Not registered in the EU, within labs/industrial R&D exemption
OSHA Hazard Communication: Complies with labeling and notification guidelines
California Proposition 65: Not listed
Other International Registries: Not controlled under major international chemical regulations
Restrictions: Use for laboratory or manufacturing purposes only; not for direct therapeutic or dietary use without regulatory approval
