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Product Name: Rosiglitazone Base
Chemical Formula: C18H19N3O3S
Synonyms: N-(2-benzyl-3-(pyridin-2-ylamino)propyl)-2-methyl-2-thiazolidinecarboxamide
CAS Number: 122320-73-4
Intended Use: Pharmaceutical research, manufacturing of medications for diabetes
Manufacturer: Pharmaceutical companies specializing in thiazolidinedione derivates
Contact Information: Manufacturers' safety office, poison control center, emergency telephone as listed on product label
GHS Classification: Acute toxicity (oral, category 4); Skin irritation (category 2); Eye irritation (category 2A)
Health Hazards: May cause irritation to eyes, skin, and mucous membranes; Inhalation or ingestion could cause nausea, headache, or dizziness; Long-term exposure may impact hepatic function
Environmental Hazards: Toxic to aquatic life, especially in large quantities; Persistent and potentially bioaccumulative in water systems
Label Elements: Warning pictogram, hazard and precautionary statements, recommended PPE usage; Emergency contact information
Chemical Identity: Rosiglitazone Base
Purity: Typically greater than 98% by HPLC
Impurities: Trace-level synthetic byproducts controlled within pharmaceutical standards
Other Components: May contain residual solvents (such as methanol, dichloromethane) from synthesis, regulated below threshold limits; No significant additives
Inhalation: Move to fresh air, monitor for respiratory distress; Seek medical attention if irritation or difficulty breathing persists
Skin Contact: Remove contaminated clothing, wash affected area thoroughly with soap and water; Seek medical advice if skin reaction develops
Eye Contact: Rinse immediately with plenty of water for at least 15 minutes, lifting eyelids; Obtain medical evaluation promptly
Ingestion: Rinse mouth; give water to drink unless individual is unconscious; Do not induce vomiting; Seek medical care immediately for evaluation and symptomatic treatment
Note to Physicians: Treat symptomatically, monitor for signs of toxicity, and provide supportive care as required
Suitable Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or foam for small fires
Specific Hazards: Combustion can generate hazardous gases including nitrogen oxides, sulfur oxides, carbon monoxide, and carbon dioxide
Protective Equipment: Firefighters should wear self-contained breathing apparatus and full protective gear
Other Advice: Avoid runoff into the environment; Use standard precautions for fires involving fine organic powders which could form combustible dust-air mixtures
Personal Precautions: Use government-approved respirators and chemical resistant gloves; Isolate spill area, restrict access
Environmental Precautions: Prevent entry into drains, water courses, or soil; Notify authorities in case of large spills
Methods for Cleanup: Carefully sweep up and place in suitable, labeled container for disposal; Clean spill area with water and detergent after material removal; Avoid raising dust
Precautions for Safe Handling: Handle with appropriate industrial hygiene practices; Minimize dust, avoid inhalation, accidental ingestion, and contact with skin or eyes
Conditions for Safe Storage: Store in tightly closed container, cool, dry, and well-ventilated area; Protect from moisture, heat, and direct sunlight
Incompatibilities: Keep separate from strong oxidizing agents, acids, or bases; Avoid proximity to solvents capable of degrading compound
Engineering Controls: Local exhaust ventilation, fume hood, or process enclosure to minimize airborne particles
Personal Protective Equipment: Chemical-resistant gloves (nitrile recommended), lab coat, safety goggles or face shield; In dusty conditions, use approved respirators
Hygiene Measures: Wash thoroughly after handling; Do not eat, drink, or smoke during use; Remove contaminated clothing before leaving work area
Appearance: White to off-white crystalline powder
Odor: Odorless
Molecular Weight: 357.43 g/mol
pH: Not readily soluble for measurement
Melting Point: 122 – 125°C
Boiling Point: Data not available; material decomposes at high temperature
Solubility: Practically insoluble in water; soluble in methanol, DMSO
Vapor Pressure: Negligible at ambient temperature
Partition Coefficient (log Kow): Estimated high, indicating hydrophobic character
Chemical Stability: Stable under normal conditions of use; Avoid conditions that generate excessive heat or moisture
Reactivity: Not known for strong reactivity; Avoid contact with oxidizing materials
Decomposition Products: On thermal decomposition produces hazardous gases, including oxides of carbon, nitrogen, and sulfur
Polymerization: No reported hazard of hazardous polymerization
Acute Toxicity: Acute oral LD50 in rats estimated greater than 2000 mg/kg; Low risk of acute poisoning with standard handling
Skin Corrosion/Irritation: May cause slight irritation on prolonged exposure; No severe effects described in literature
Eye Effects: Moderate irritant to eyes
Chronic Exposure: Prolonged or repeated exposure may affect liver or cause allergic responses in susceptible individuals; Use of PPE reduces risks
Carcinogenicity/Mutagenicity: Not classified as human carcinogen; Long-term animal studies have not demonstrated significant risk at pharmaceutical doses
Sensitization: May cause allergic reactions on repeated contact in some individuals
Aquatic Toxicity: Ecotoxic substance, harmful to aquatic organisms; Long persistence and potential for accumulation, particularly in sediments
Mobility: Low solubility in water reduces mobility; Tends to remain in solid state or adsorb onto sediments
Degradability: Biodegradation is slow; Stable under most environmental conditions
Bioaccumulation: High potential due to hydrophobicity, warranting careful containment and disposal practices
Waste Treatment Methods: Dispose of as hazardous pharmaceutical waste in accordance with local, national, and international regulations
Incineration: Incinerate in approved facility with appropriate air pollution controls
Container Disposal: Triple rinse and render non-reusable; Follow legal requirements to manage contaminated packaging
Avoid Release: Prevent substance from contaminating land, drains, or natural water systems
UN Number: Not specifically assigned unless transported in bulk as hazardous waste
Transport Hazard Class: Not categorized as hazardous for transport under most regulations, but follow guidelines for pharmaceuticals
Packing Group: Not applicable for most standard quantities
Special Precautions: Protect against contamination, mechanical shock, and sources of ignition during transport; Carry documentation
Safety, Health and Environmental Regulations: Subject to workplace safety rules for hazardous pharmaceuticals; Listed in regulatory databases such as REACH and TSCA if handled in larger scale
Labeling Requirements: Product labeling must include hazard statements, recommended personal protection, and first aid instructions
Inventory Status: Listed or under evaluation by global inventory systems for pharmaceutical ingredients; Reporting and use restrictions may apply in some jurisdictions
Other Requirements: Users must comply with all applicable laws including OSHA, EPA, and relevant local agencies for laboratory and workplace safety
