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Product Name: Rocuronium Bromide
CAS Number: 119302-91-9
Molecular Formula: C32H53BrN2O4
Recommended Use: Pharmaceutical muscle relaxant, reference standard in labs
Manufacturer/Supplier: Major pharmaceutical companies and chemical suppliers worldwide
Emergency Phone Number: Accessible 24/7 through local poison control or manufacturer’s helpdesk
SDS Number: Specific identifier assigned by supplier
Hazard Classification: Toxic if swallowed or in contact with skin, causes serious eye irritation, respiratory irritant
Signal Word: Danger
Hazard Statements: H301 - Toxic if swallowed, H315 - Causes skin irritation, H319 - Causes serious eye irritation, H335 - May cause respiratory irritation
Pictograms: Skull and crossbones, Exclamation mark
Precautionary Statements: Do not handle without proper protective equipment; wash thoroughly after handling; avoid breathing dust or vapors; use only in a chemical fume hood.
Chemical Name: Rocuronium Bromide
Concentration: 100% for pure substance, lower in formulated products
Impurities: In trace amounts, supplier-specific
Synonyms: 1-[17β-Acetoxy-3α-hydroxy-2β-(4-morpholinyl)-5α-androstan-16β-yl]-1-methylpiperidinium bromide, Esmeron
Inhalation: Move the person into fresh air immediately, keep victim at rest, seek medical advice without delay
Skin Contact: Remove contaminated clothing and rinse thoroughly with soap and water, seek urgent medical care for persistent irritation or symptoms
Eye Contact: Rinse carefully with running water for at least 15 minutes, eyelids apart; remove contact lenses if present and easy to do, immediate medical attention is necessary
Ingestion: Rinse mouth thoroughly, call poison control or medical provider right away, do not attempt to induce vomiting unless directed by health professionals
Most Important Symptoms and Effects: Muscle weakness, paralysis, respiratory distress, central nervous system depression
Suitable Extinguishing Media: Dry chemical, carbon dioxide, foam, water spray for larger fires
Specific Hazards: Toxic fumes of nitrogen oxides, carbon oxides, and hydrogen bromide released during combustion
Protective Equipment for Firefighters: Self-contained breathing apparatus, chemical-resistant gloves and full protective suit
Special Precautions: Avoid breathing smoke, contain runoff with sand or earth to prevent contamination of drains or watercourses
Personal Precautions: Isolate area, ventilate the space, restrict access to trained personnel using appropriate PPE
Environmental Precautions: Prevent further leakage or spillage, keep material from entering drains, surface water, or soil
Methods for Cleanup: Absorb with inert dry material such as sand, collect in suitable container for disposal, wash site with copious water after cleanup and ventilate area thoroughly
Safe Handling Advice: Use sealed containers, avoid inhalation and contact with skin or eyes, employ chemical fume hood
Storage Conditions: Store tightly closed at 2-8°C, protected from light, moisture, extreme temperatures, keep separate from incompatible substances such as strong acids and oxidizers
Do Not Store With: Foods, animal feeds, beverages, incompatible chemicals
Occupational Exposure Limits: No specific limits established, minimize exposure in lab and manufacturing settings
Engineering Controls: Laboratory fume hood, local exhaust ventilation
Personal Protective Equipment: Nitrile gloves, chemical splash goggles, lab coat, respiratory protection if dust or aerosol formation likely
Hygiene Measures: Wash hands and face after handling, avoid eating or drinking in work area, remove contaminated clothing and wash thoroughly before reuse
Appearance: White to off-white crystalline powder
Odor: Odorless or faint characteristic odor
Molecular Weight: 610.7 g/mol
Melting Point: Decomposes above 230°C
Solubility: Soluble in water, less soluble in ethanol
pH: 4.0–5.0 (1% in water)
Boiling Point: Not applicable (decomposes)
Vapor Pressure: Negligible at room temperature
Partition Coefficient: LogP not readily available; low lipid solubility
Chemical Stability: Stable under recommended storage conditions
Conditions to Avoid: Moisture, strong heat, light, and incompatible materials
Incompatible Materials: Strong acids, oxidizers, alkalis
Hazardous Decomposition Products: Upon combustion, releases carbon monoxide, carbon dioxide, nitrogen oxides, hydrogen bromide
Reactivity: No hazardous reactivity expected with common laboratory materials under normal conditions
Routes of Exposure: Inhalation, ingestion, skin and eye contact
Acute Toxicity: Can cause muscle paralysis and respiratory arrest if ingested or absorbed, animal studies show LD50 around 0.7–2 mg/kg IV
Chronic Toxicity: No long-term human exposure data, repeated skin contact may lead to sensitization or allergic reactions
Symptoms: Muscle weakness, severe drop in blood pressure, breathing difficulty, risk of death if medical help not sought quickly
Carcinogenicity: Not classified as carcinogenic by ACGIH, IARC, NTP, or OSHA
Mutagenicity and Reproductive Toxicity: No data indicating risk to reproductive health or mutagenicity in humans
Aquatic Toxicity: Potentially harmful to aquatic organisms at higher concentrations, data limited
Persistence and Degradability: Not readily biodegradable, persistence in the environment not well documented
Bioaccumulative Potential: Expected low potential for bioaccumulation based on structure and solubility
Mobility in Soil: Likely to bind to soil particles due to ionic nature, transport to groundwater considered low
Other Adverse Effects: Use with care to prevent contamination of water bodies, no indication of ozone depletion or significant environmental hazard from proper laboratory use
Disposal Methods: Dispose of as hazardous pharmaceutical waste; incineration preferred whenever feasible
Do Not: Pour down drain or allow entry to open waters or soil
Contaminated Packaging: Decontaminate containers before recycling or dispose of as hazardous chemical waste according to local regulations
Recommended Disposal: Follow established guidelines from local environmental and waste management authorities, seek professional hazardous waste handler
UN Number: Not classified under major UN dangerous goods regulations
Transport Hazard Class: Not regulated for transport by air, sea, or road in most jurisdictions; handle as potentially toxic material
Packing Group: None assigned
Proper Shipping Name: Rocuronium Bromide, non-hazardous unless transported in large quantities
Special Precautions: Package securely to prevent leaks, carry appropriate documentation for research quantity shipments, notify carrier if material spills occur during transport
US TSCA: Not listed
FDA: Approved as a prescription-only active ingredient in human medicine
OSHA: Not specifically regulated, treated as hazardous
REACH Status: Not registered or pre-registered due to pharmaceutical use
SARA Title III: Not listed as a hazardous substance, but should be handled with care in all workplace environments
State Regulations: Subject to state and local environmental and chemical handling legislation
Other Information: Confirm current local environmental, health, and safety rules before purchasing, transporting, or disposing of this material
