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Product Name: Riluzole
Chemical Name: 2-Amino-6-(trifluoromethoxy)benzothiazole
Synonyms: Rilutek
CAS Number: 1744-22-5
Molecular Formula: C8H5F3N2OS
Recommended Use: Pharmaceutical raw material, therapeutic in amyotrophic lateral sclerosis (ALS)
Supplier Details: [Supplier information to be obtained from manufacturer or distributor]
Emergency Contact: Refer to local poison control center or emergency medical services
GHS Classification: Acute toxicity (Oral, Dermal, Inhalation), Eye irritation, Skin irritation
Signal Word: Warning
Hazard Statements: Harmful if swallowed, in contact with skin, or if inhaled. Causes skin and eye irritation. Suspected of damaging fertility or the unborn child.
Precautionary Statements: Avoid breathing dust. Wash exposed skin thoroughly. Use personal protective equipment. Avoid release to the environment.
Potential Health Effects: Inhalation leads to irritation of respiratory tract, ingestion causes gastrointestinal discomfort, prolonged skin contact may induce dermatitis.
RTECS Number: Not available
Substance: Riluzole
Concentration: ≥98% pure
CAS Number: 1744-22-5
Impurities: Generally contains process-related impurities <2%, details per batch report
Other Ingredients: None of concern reported for raw material
Inhalation: Remove casualty to fresh air. Seek medical attention if symptoms appear.
Skin Contact: Remove contaminated clothing. Wash skin thoroughly with mild soap and running water.
Eye Contact: Rinse cautiously with clean water for several minutes, holding eyelids open. Remove contact lenses if present.
Ingestion: Rinse mouth. Do not induce vomiting unless instructed by a medical authority. Consult a physician immediately.
Most Important Symptoms: Respiratory distress, skin inflammation, eye irritation, gastrointestinal pain.
Advice to Physician: Treat symptomatically and monitor vital signs.
Suitable Extinguishing Media: Water spray, dry chemical, carbon dioxide, foam.
Unsuitable Media: Direct water jets on burning solids.
Hazardous Combustion Products: Emits toxic fumes, including nitrogen oxides, sulfur oxides, hydrogen fluoride, carbon monoxide.
Protective Equipment: Wear full protective gear, positive pressure self-contained breathing apparatus.
Specific Hazards: Fine particulate dust in air may ignite under rare conditions.
General Firefighting Strategy: Stay upwind, evacuate downwind areas, prevent contaminated runoff.
Personal Precautions: Wear gloves, lab coat, approved respirator, safety goggles. Avoid dust formation and all personal contact with product.
Environmental Precautions: Prevent entry into sewers, soil, surface water, or drainage systems.
Containment: Sweep up gently to prevent dust rise. Use damp cloths when possible. Collect in tightly sealed, labeled containers for proper disposal.
Cleanup Methods: Ventilate spill area. Dispose contaminated materials following local and national regulations.
Decontamination: Wash surfaces thoroughly with soap and water or suitable detergent.
Handling Precautions: Handle in a well-ventilated area. Use gloves, eye protection, lab clothing. Prevent substance contact with skin, clothing, and eyes. Wash hands before breaks and after handling.
Safe Storage Conditions: Store locked up in cool, dry, well-ventilated place away from incompatible materials. Keep containers tightly closed and properly labeled.
Incompatibilities: Strong oxidizing agents, strong acids, strong bases.
Special Storage: Store in original container. Secure from unauthorized access.
Fire Protection: Keep away from sources of ignition. No smoking.
Exposure Limits: No occupational exposure limit assigned. Use workplace monitoring as appropriate.
Engineering Controls: Use chemical fume hood. Ventilate laboratory and processing areas.
Personal Protective Equipment: Gloves (nitrile recommended), safety goggles, chemical-resistant apron or lab coat.
Respiratory Protection: Dust mask or NIOSH approved particulate respirator if airborne exposure risk exists.
Hygiene Measures: Avoid eating, drinking, or smoking in work area. Remove contaminated clothing immediately. Routine handwashing after use.
Appearance: Off-white to light beige crystalline powder
Odor: Odorless
Odor Threshold: Not determined
pH: Slightly acidic to neutral (aqueous solution)
Melting Point: About 116–118°C
Boiling Point: Decomposes before boiling
Flash Point: Not available
Flammability: Non-flammable under normal conditions
Explosion Limits: Not determined
Vapor Pressure: Negligible at room temperature
Vapor Density: Not applicable
Solubility: Low water solubility, soluble in dimethyl sulfoxide (DMSO), methanol
Partition Coefficient (log Pow): 2.3
Autoignition Temperature: Not established
Decomposition Temperature: Decomposes at high temperatures
Chemical Stability: Stable under recommended storage conditions
Reactivity: Not known to be reactive under normal use and storage.
Hazardous Decomposition Products: Carbon oxides, sulfur oxides, nitrogen oxides, hydrogen fluoride under strong heating.
Polymerization: Will not occur.
Incompatible Materials: Strong oxidizing agents, acids, bases.
Conditions to Avoid: Heat, light, moisture, source of ignition.
Routes of Exposure: Inhalation, ingestion, dermal absorption, eye contact
Acute Toxicity: Oral LD50 (rat): ≥ 260 mg/kg
Skin Irritation: Causes moderate skin irritation with repeated contact
Eye Irritation: May cause significant irritation
Sensitization: Not expected to sensitize skin
Chronic Effects: Target organ effects primarily on liver, CNS. Animal studies showed reproductive effects.
Carcinogenicity: Not listed as carcinogen by IARC, NTP, OSHA
Mutagenicity: Limited evidence from in vitro and animal studies
Reproductive Toxicity: Animal data suggest potential for reproductive effects. Precaution strongly advised for pregnant individuals.
Ecotoxicity: Harmful to aquatic organisms, may cause long-term adverse effects in aquatic environments
Mobility in Soil: Not volatile. Low mobility expected due to moderate adsorption
Persistence and Degradability: Not readily biodegradable. May persist in water or soil
Bioaccumulation: Low to moderate potential based on partition coefficient
Other Adverse Effects: Discharge into environment poses risk to aquatic and terrestrial organisms. Avoid contamination of waterways
Product Disposal: Incinerate under controlled conditions at a licensed facility, following local, national, and international regulations
Contaminated Packaging: Treat as hazardous waste. Rinse thoroughly, destroy if contaminated
Disposal Methods: Do not discharge into drains, surface waters, or soil. Store and transport in tightly sealed, labeled containers awaiting disposal
Special Notes: Contact licensed chemical waste disposal contractor. Obey local environmental agencies.
UN Number: Not assigned for this compound
UN Proper Shipping Name: Not regulated for transport as dangerous goods
Transport Hazard Class: Not classified
Packing Group: Not categorized
Environmental Hazards: Avoid large quantity releases to environment
Special Precautions: Protect containers from physical damage, store upright during transit
EU Regulation: Listed as a pharmaceutical ingredient, subject to REACH registration exemption
US Regulations: Not regulated as a hazardous substance under SARA Title III, TSCA inventory. Handled under FDA and DEA as active pharmaceutical ingredient
Canada: Listed as prescription medication under Food and Drug Act, subject to import/export control
Workplace: Regulated as hazardous chemical under OSHA HCS, safe handling measures enforced
Other National/International Regulations: Appropriate licensing and permits required for manufacture, import, or use in line with country-specific drug and chemical laws
Labeling Requirements: Hazard pictograms, risk phrases, safety precautions as per GHS, OSHA or regional standards. Maintain safety documentation for inspection and compliance.
