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Product Name: Rifandin / Rifamycin, 3-[4-(2-Methylpropyl)-1-Piperazinyl]-
Chemical Family: Rifamycins
Synonyms: 3-[4-(2-Methylpropyl)-1-piperazinyl]rifamycin, Rifampin derivative
Recommended Use: Pharmacological/antibiotic agent
Manufacturer: Specified on supplier’s label
Contact Information: Found on label or provided by the purchasing department
Emergency Contact Number: Refer to Safety Compliance Officer or Poison Control
Classification: Eye irritation (Category 2), Skin sensitization (Category 1), Specific target organ toxicity
Signal Word: WARNING
Hazard Statements: Causes serious eye irritation. May cause an allergic skin reaction. Suspected of causing genetic defects. May cause damage to liver through prolonged exposure.
Pictogram: Exclamation mark, Health hazard
Precautionary Statements: Avoid breathing dust. Wash exposed skin thoroughly after handling. Use protective equipment. Avoid release to the environment.
Chemical Name: Rifandin / Rifamycin, 3-[4-(2-Methylpropyl)-1-Piperazinyl]-
CAS Number: 13292-46-1
Purity: Typically 98% or higher
Impurities: Trace amounts of related rifamycin substances, solvents, and piperazinyl derivatives
Mixture: Single-component chemical, no hazardous additives reported
Inhalation: Move person to fresh air immediately. Seek medical attention if persistent cough or difficulty breathing develops. Monitor for delayed respiratory symptoms.
Eye Contact: Flush eyes with water for 15 minutes. Hold eyelids open and rinse thoroughly. If irritation persists, consult a physician without delay.
Skin Contact: Remove contaminated clothing. Wash affected area with soap and water. Seek medical advice for rash, redness, or allergic reaction.
Ingestion: Rinse mouth. Do not induce vomiting. Give water to conscious individual. Call poison control or physician for further guidance.
Most Important Symptoms/Effects: Allergic skin reactions, eye irritation, liver effects with long-term exposure
Suitable Extinguishing Media: Use water spray, alcohol-resistant foam, dry chemical, or carbon dioxide.
Unsuitable Extinguishing Media: Do not use strong water jet as product may disperse.
Specific Hazards: May produce toxic fumes (nitrogen oxides, carbon monoxide, carbon dioxide) under fire conditions.
Protective Equipment: Firefighters should wear self-contained breathing apparatus and full protective gear.
Advice for Firefighters: Move containers from fire area if safe to do so. Prevent run-off from entering drains, sewers, or waterways.
Personal Precautions: Keep unauthorized individuals out. Wear eye protection, gloves, and dust mask.
Environmental Precautions: Prevent product from entering soil, waterways, drains, or confined areas. Notify environmental personnel if contamination of land or water is suspected.
Cleanup Methods: Sweep up material carefully to avoid dust formation. Place in suitable, sealed containers for disposal. Wash spill area thoroughly with water and detergent if needed.
Handling: Minimize dust generation. Use in well-ventilated areas. Wash hands before eating or drinking. Do not handle in food preparation areas.
Storage: Store in tightly closed container. Keep in cool, dry, and ventilated place away from sunlight and moisture. Do not store near acids, oxidizing agents, or incompatible substances. Follow all applicable regulations and local guidelines for storage.
Occupational Exposure Limits: No specific limits established, control exposure to lowest feasible levels.
Engineering Controls: Use local exhaust ventilation or fume hood for laboratory handling.
Personal Protection: Use chemical-resistant gloves, lab coat, eye protection (goggles), and approved respiratory protection for dust.
Hygiene Measures: Remove contaminated clothing promptly. Avoid contact with eyes, skin, and clothing. Wash thoroughly after handling.
Environmental Exposure Controls: Direct discharge to environment must be avoided. Collect washings for proper disposal.
Appearance: Orange to brown crystalline powder
Odor: Odorless or faint chemical odor
pH: Not applicable for solid form
Melting Point/Range: Approximately 183–188°C
Boiling Point: Not measured (decomposes)
Flash Point: Not flammable under normal conditions
Solubility: Slightly soluble in water, freely soluble in organic solvents (e.g., methanol, chloroform)
Partition Coefficient (Log Kow): Not established
Vapor Pressure: Not applicable
Density: 1.1–1.3 g/cm³ (estimated)
Other Sensory Details: Can stain surfaces and skin
Chemical Stability: Stable under standard storage and handling conditions
Conditions to Avoid: Moisture, light, and heat above room temperature can degrade product quality
Incompatible Materials: Strong acids, oxidizers, and strong bases can cause hazardous reactions
Decomposition Products: Thermal decomposition releases carbon oxides, nitrogen oxides, and potentially toxic fumes
Hazardous Polymerization: Not known to occur with proper handling
Acute Toxicity: Oral and inhalation toxicity can range from mild irritation to severe, based on dose
Chronic Toxicity: Long-term exposure may affect liver function, cause blood changes, and trigger allergic responses
Routes of Exposure: Inhalation, skin contact, eye contact, ingestion
Symptoms: Skin sensitization, rash, conjunctival irritation, mild respiratory effects
Carcinogenicity: No confirmed human data, but genotoxic effects have been noted in in vitro studies
Additional Data: Potential for mutagenicity. Not listed by IARC, NTP, or OSHA as carcinogen.
Eco-Toxicity: Harmful to aquatic organisms. May cause long-term adverse effects in the aquatic environment.
Persistence and Degradability: Moderate to low biodegradability, may persist in water and soil
Bioaccumulation: Potential for moderate bioaccumulation
Mobility: Limited mobility in soil, but can spread via water
Other Adverse Effects: Antibiotic residues may disrupt microbial populations in sewage treatment plants or soil
Waste Disposal Method: Dispose of in accordance with local, regional, national, and international regulations
Considerations: Incinerate or landfill as hazardous pharmaceutical waste, preventing release to sewage or surface water
Container Disposal: Decontaminate before disposal or use specialized hazardous waste contractor
Recommended Practices: Do not mix with general waste streams. Avoid disposal by drain or sanitation system.
UN Number: Not regulated under standard transport codes, confirm with carrier
Transport Hazard Class: Not assigned
Packing Group: Not classified
Labels: Not required unless mixed with other hazardous materials
Special Precautions: Keep container sealed and secure. Protect package from crushing or puncture, limit exposure to moisture and heat.
Regulatory Status: Subject to chemical hygiene, pharmaceutical, and transport laws
OSHA: Considered hazardous by definition of Hazard Communication Standard
TSCA Status: Not listed for commercial distribution in the US
EU Regulations: Classified under CLP Regulation EC 1272/2008 as hazardous
Inventory Listings: Not listed on major chemical inventories for industrial chemicals; regulated under pharmaceutical control lists
Other Regulatory Notes: Worker protection requirements apply in research, clinical, or pharmaceutical settings. Comply with all country-specific regulations regarding handling, exposure, and reporting.
