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Product Name: Rifamycin S Sodium
Synonyms: Rifamycin sodium salt
Chemical Family: Rifamycins
Recommended Use: Antibiotic, medicinal chemistry
Manufacturer Contact: Emergency phone numbers and supplier details specific to source
CAS Number: 14897-39-3
GHS Classification: Skin Sensitizer, Eye Irritant, Specific Target Organ Toxicity (Single Exposure)
Signal Word: Warning
Hazard Statements: May cause allergic skin reaction, causes eye irritation, potential for respiratory irritation
Precautionary Statements: Avoid contact with eyes, skin, clothing. Do not breathe dust or aerosols. Wash hands thoroughly after handling. Wear suitable personal protective equipment.
Chemical Name: Rifamycin S Sodium
CAS Number: 14897-39-3
Concentration: 98% or greater
Impurities: Minimal nonhazardous excipients, proprietary stabilizers (if any)
Inhalation: Remove to fresh air; seek medical attention for persistent irritation or difficulty breathing.
Skin Contact: Wash with soap and water for several minutes. Remove contaminated clothing. Obtain medical help if irritation develops.
Eye Contact: Rinse cautiously with water for at least 15 minutes. Seek medical care if irritation persists.
Ingestion: Rinse mouth, never induce vomiting unless directed by medical personnel. Medical supervision suggested.
Most Important Acute/Delayed Symptoms: Allergic reaction, respiratory or eye irritation.
Indication of Medical Attention Needed: Persistent discomfort or allergic response.
Suitable Extinguishing Media: Dry chemical, carbon dioxide, foam, or water spray.
Special Hazards from Substance/Preparation: Combustion or thermal decomposition yields toxic fumes, including oxides of carbon and nitrogen.
Protective Equipment for Firefighters: Self-contained breathing apparatus, complete protective clothing.
Fire-Fighting Precautions: Move containers away from fire area if possible. Avoid inhaling combustion gases.
Personal Precautions: Evacuate area, avoid dust formation. Wear protective gloves, goggles, and suitable laboratory coat.
Environmental Precautions: Prevent runoff into drains or surface water. Notify authorities for significant spills.
Methods for Clean Up: Collect material with vacuum system equipped with HEPA filter or wet sweeping; place in compatible chemical waste container for disposal.
Handling: Handle in well-ventilated, adequately-equipped laboratory. Minimize exposure or contact with substance. Use techniques that avoid dust and aerosol generation.
Storage Conditions: Store tightly sealed in a cool, dry, dark place. Protect from incompatible substances and moisture.
Incompatible Materials: Strong oxidizing agents, strong acids.
Specific Use(s): Antibiotic for research or clinical use under prescription and supervision.
Engineering Controls: Use chemical fume hood and local exhaust ventilation wherever possible.
Eye Protection: Chemical safety goggles.
Hand Protection: Nitrile or latex gloves.
Skin/Body Protection: Laboratory coat and appropriate footwear.
Respiratory Protection: NIOSH-approved respirator for powders/aerosols if exposure limits are exceeded.
Hygiene Measures: Do not eat, drink, or smoke in work area. Wash thoroughly after handling and before breaks.
Appearance: Red to orange-brown powder
Odor: Odorless or faint medicinal scent
pH of Solution: 6.7-7.7 (1% aqueous solution)
Melting Point: Decomposes before melting
Boiling Point: Not applicable (solid, decomposes)
Solubility: Freely soluble in water; slightly soluble in ethanol
Vapor Pressure: Not determined
Partition Coefficient (log Pow): Not available
Other Physical Information: Stable under recommended conditions; moisture sensitive.
Chemical Stability: Stable under suggested storage conditions, sensitive to humidity and light.
Hazardous Reactions: None known for intended use.
Materials to Avoid: Oxidizing agents, acids, moisture
Hazardous Decomposition Products: Carbon oxides, nitrogen oxides and unidentified organic fragments during combustion.
Conditions to Avoid: Incompatible chemicals, excessive heat, direct sunlight, humidity.
Acute Toxicity: LD50 data limited; considered moderately toxic by ingestion based on analog compounds.
Skin Corrosion/Irritation: Possible irritant based on human and animal data on rifamycins.
Eye Damage/Irritation: Eye irritant; may cause redness, watering.
Respiratory or Skin Sensitization: Potential skin sensitizer; reports of allergic dermatitis in humans.
Germ Cell Mutagenicity: Not classified; insufficient data.
Carcinogenicity: IARC not classified; no evidence from available data.
Reproductive Toxicity: Limited evidence; use during pregnancy only if clearly needed.
Other Effects: Overexposure may cause liver effects, mild CNS symptoms, orange-red discoloration of body fluids.
Ecotoxicity: Data not complete for aquatic or terrestrial toxicity. Antibiotic may disrupt microbial communities.
Persistence and Degradability: Likely not readily biodegradable. Potential for long-term persistence.
Bioaccumulative Potential: Unlikely to bioaccumulate significantly.
Mobility in Soil: May leach to groundwater in case of spillage.
Other Adverse Effects: Avoid environmental release, as antibiotics may impact non-target organisms.
Waste Disposal Methods: Collect and dispose of as hazardous pharmaceutical waste. Use licensed service for incineration or approved landfill.
Contaminated Packaging: Dispose of empty containers using same precautions as for the material itself.
Other Disposal Recommendations: Follow local, regional, and national regulations for pharmaceutical waste.
UN Number: Not assigned for this material
UN Proper Shipping Name: Rifamycin S Sodium
Transport Hazard Class: Not classified as dangerous for transportation
Packing Group: Not regulated
Environmental Hazards: Not listed as marine pollutant
Special Precautions: Protect containers from physical damage and heat during transport.
OSHA Hazards: Sensitizer, Irritant
TSCA Status: Not listed
SARA Section 313 (Specific Toxic Chemicals): Not reportable
EU REACH Status: Not registered for bulk commercial use
Other National Regulations: Subject to pharmaceutical and medicinal chemical regulations. Handle according to the workplace safety standards for hazardous drugs.
