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Product Name: Rifamycin O
Chemical Formula: C37H47NO12
CAS Number: 14897-39-3
Other Names: Rifamycin SV O derivative
Synonyms: Rifamycin-O, 3-Formylrifamycin
Intended Use: Pharmaceutical research and development, antibiotic production
Supplier: Refer to invoice or packaging
Contact Number for Emergency: Refer to product documentation
Recommended Restrictions: Laboratory use under guidance of qualified professionals only
Classification: Not classified as hazardous under GHS for pure compound, but dust may cause respiratory irritation
Signal Word: Not applicable
Hazard Statements: May cause skin or eye irritation; inhalation of dust could provoke allergic reactions in sensitized individuals
Precautionary Statements: Avoid breathing dust, wash thoroughly after handling, use in well-ventilated area
Routes of Exposure: Inhalation, skin contact, eye contact, ingestion
Symptoms: Eyes may redden or water, sneezing or mild cough possible with inhalation, skin might become itchy or irritated after frequent or prolonged exposure
Pictograms: Not required for pure compound in most countries, consult local guidelines
Chemical Name: Rifamycin O
Concentration: ≥98% (pharmaceutical grade typical)
Impurities: Minor analogues, under 2% in typical batches
Stabilizing Additives: May include trace stabilizers pertinent to vendor supply
Eye Contact: Rinse cautiously with large quantities of clean water for at least 15 minutes, removing contact lenses if present and easy to do
Skin Contact: Wash exposed area with soap and water, remove contaminated clothing, seek medical attention if irritation or redness persists
Inhalation: Move person to fresh air, support breathing as needed; seek medical help if symptoms continue
Ingestion: Rinse mouth, do not induce vomiting unless directed by qualified personnel, get medical attention promptly
Medical Attention: Call for assistance with persisting symptoms or if allergic reactions are suspected
Most Important Symptoms: Mild eye/skin irritation, possible respiratory discomfort
Suitable Extinguishing Media: Water spray, dry chemical, carbon dioxide, foam
Unsuitable Extinguishing Media: Avoid high-pressure water streams directly on burning substance
Special Hazards: Combustion releases oxides of carbon, nitrogen compounds, dense smoke
Protective Equipment and Precautions: Firefighters wear self-contained breathing apparatus and protective gear
Specific Hazards: Containers may rupture when heated; avoid inhaling smoke or vapors
Thermal Decomposition: Produces toxic fumes, including CO, CO₂, and nitrogen oxides, so ventilate area well in case of fire
Personal Precautions: Wear gloves, protective coat, dust mask or respirator if significant airborne dust forms
Environmental Precautions: Prevent material from entering drains, water supplies, or soil
Cleanup Methods: Scoop or sweep carefully to avoid dust, use damp cloth or paper for final residue; keep in sealed containers for disposal
Emergency Procedures: Isolate spill area, provide ventilation, avoid contact with released material
Precautions for Safe Handling: Work with gloves and eye protection, minimize dust generation; avoid eating, drinking, or smoking around material
Safe Storage Conditions: Store in tightly closed container, in dry, cool, and well-ventilated place; shield from strong light and direct heat
Incompatible Materials: Strong acids, strong bases, oxidizers
Handling Practices: Use equipment that can be easily cleaned, label all containers with chemical name and handling instructions
Specific Use(s): Limit to laboratory, pilot-plant, or regulated manufacturing environments
Engineering Controls: Use fume hood or local exhaust for tasks creating airborne dust
Occupational Exposure Limits: Not established for Rifamycin O; minimize exposure as for nuisance dusts (e.g., OSHA PEL for total dust 15 mg/m3)
Personal Protection: Eye protection (safety goggles), gloves (nitrile or latex), lab coat, dust mask (N95 or better) for dry compounds
Hygiene Measures: Wash thoroughly after use, avoid contamination of personal clothing
Environmental Controls: Avoid releases to environment by containing powder, dispose of waste via licensed contractor
Appearance: Reddish-orange to brown powder
Odor: Slight, musty
Odor Threshold: No information available
pH: Slightly acidic to neutral in water (approx. 6–7)
Melting Point: 178–185°C (decomposes)
Boiling Point: Not applicable (decomposes before boiling)
Flash Point: Not determined; combustible solid
Solubility: Slightly soluble in water, soluble in methanol, ethyl acetate, chloroform
Vapor Pressure: Not available
Partition Coefficient (n-octanol/water): Data not set
Specific Gravity: Approx. 1.4–1.5 (estimated)
Decomposition Temperature: Above 180°C
Chemical Stability: Stable under normal conditions of use and storage
Possibility of Hazardous Reactions: No hazardous polymerization
Conditions to Avoid: Exposure to moisture, excessive heat, direct sunlight
Incompatible Materials: Strong acids, strong oxidizers, strong bases
Hazardous Decomposition Products: Carbon oxides, nitrogen oxides, irritant smoke or vapors
Reactivity: Not highly reactive; reacts sensitively to acid or base hydrolysis, may degrade in presence of strong oxidants
Acute Toxicity: Oral LD50 in rodents (rat, mouse) reported >2,000 mg/kg; low acute toxicity profile
Skin Corrosion/Irritation: Mildly irritating to skin on repeated/prolonged exposure
Serious Eye Damage/Irritation: Can produce mild conjunctival irritation
Respiratory Sensitization: Not documented in public literature, but dust may prompt asthma-like symptoms in sensitized individuals
Skin Sensitization: Rare allergic reaction on skin observed in sensitive individuals
Mutagenicity/Carcinogenicity: No evidence of carcinogenic effect in animal studies; mutagenicity data limited, as with other rifamycins
Long-Term Exposure Effects: Possible changes to liver enzymes, as observed with related compounds at high repeated doses
Symptoms of Overexposure: Erythema, pruritus, mild breathing difficulty, gastrointestinal symptoms after ingestion
Aquatic Toxicity: Limited data; related compounds show moderate to low toxicity to aquatic life; avoid discharge to waterways
Persistence and Degradability: Expected to degrade slowly in the environment; may bind to sediments
Bioaccumulative Potential: Not significant based on expected pharmacokinetics in mammals
Mobility in Soil: Moderate estimate, potential to move into groundwater via soil under heavy use
Other Adverse Effects: Unknown effects on terrestrial organisms and plants; avoid broad environmental release
Precautions: Offer for disposal in accordance with local regulations, never dump in drains or sewers
Waste Treatment Methods: Collect solid residues into sealed, labelled containers for disposal at chemical waste facility
Disposal of Contaminated Packaging: Triple rinse empty containers, render unusable before discarding in regulated waste stream
Precautions: Do not dispose along with household waste, keep away from surface water
Other Information: Comply with local, regional, and national environmental regulations; consult licensed waste professionals
UN Number: Not classified as dangerous for transport under most jurisdictions
UN Proper Shipping Name: Not regulated
Transport Hazard Class: Not regulated
Packing Group: Not applicable
Environmental Hazards: Not a marine pollutant
Transport Precautions: Protect from moisture and excessive heat; ensure container integrity throughout transit
Special Transport Notes: Minimize risk of breakage or spillage; secure containers firmly, label clearly for customs or regulatory inspection if needed
Reference to Local and International Regulations: This compound may fall under pharmaceutical precursor controls in certain countries
OSHA: Not listed as hazardous chemical under US OSHA HazCom regulations
TSCA: Not listed (pharmaceutical research chemical/excluded from inventory)
REACH: Exempt as research or pharmaceutical chemical in Europe; check latest ECHA updates for new mandates
WHMIS: Not classified as a controlled product (Canada)
Other Region-Specific Rules: Exact handling and labeling regulations can differ by country; always consult current national chemical safety guidelines for specific obligations
Label Requirements: Precautionary labelling as sensible: “For laboratory use only. Avoid inhalation and contact with skin or eyes.”
Restrictions: Only for professional, industrial, or research use; not for food, drug, or household applications without further licensing
