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Product Name: Rifabutin
Chemical Formula: C46H62N4O16
Synonyms: Ansamycin, Butans
Manufacturer: Various pharmaceutical companies
Contact Information: Emergency phone numbers provided by supplier
Recommended Use: Antimicrobial agent, primarily for Mycobacterium avium complex
CAS Number: 72559-06-9
GHS Classification: Harmful if swallowed, possible respiratory sensitizer, skin/eye irritant
Signal Word: Warning
Hazard Statements: May cause allergic skin reaction, may cause mild irritation to eyes or respiratory tract, possible liver enzyme elevation in long-term exposure
Pictograms: Exclamation mark
Precautionary Statements: Avoid inhalation, contact with skin and eyes; wash thoroughly after handling; do not eat or drink around the product
Chemical: Rifabutin
Purity: 98–100%
Impurities: Trace solvent residues (from pharmaceutical synthesis), not classified as hazardous in typical concentrations
Molecular Weight: 847.0 g/mol
Inhalation: Move to fresh air, keep at rest, seek medical attention if symptoms persist
Skin Contact: Remove contaminated clothing, wash with soap and water, consult physician for persistent irritation
Eye Contact: Rinse thoroughly with running water for at least 15 minutes, seek medical help if irritation doesn’t clear
Ingestion: Rinse mouth, seek medical advice, do not induce vomiting unless instructed by medical personnel
Advice for Medical Team: Symptomatic and supportive treatment, consider allergic reaction protocols
Suitable Extinguishing Media: Dry powder, carbon dioxide, foam
Unsuitable Extinguishing Media: Direct water stream
Hazardous Combustion Products: Carbon monoxide, carbon dioxide, nitrogen oxides, toxic fumes possible
Special Procedures: Wear self-contained breathing apparatus and full protective gear
Special Hazards: Fine particles may form explosive dust-air mixtures, avoid inhalation
Personal Precautions: Avoid dust formation, avoid breathing dust, ventilate area
Environmental Precautions: Prevent run-off to surface water or drains
Cleanup Methods: Collect in sealed containers for disposal, mop area with damp cloth, ventilate area
Protective Equipment: Gloves, safety glasses, NIOSH-approved respirator for large spills
Handling: Use with adequate ventilation, wear protective equipment, avoid ingestion and inhalation
Storage Conditions: Store in tightly closed container, cool and dry location, away from direct sunlight and incompatible materials
Incompatibilities: Strong oxidizers, acids, bases
Specific End Uses: Only for pharmaceutical compounding and research
Exposure Limits: No established US OSHA or ACGIH exposure limits
Engineering Controls: Use fume hood, local exhaust ventilation
Respiratory Protection: Approved respirator when dust exposure exists
Skin Protection: Nitrile gloves, lab coat
Eye Protection: Chemical safety goggles
Hygiene Measures: Wash hands thoroughly after handling, remove contaminated clothing
Appearance: Reddish-orange powder
Odor: Odorless or faint medicinal scent
pH: Not available (water insoluble)
Melting Point: 180–185°C
Boiling Point: Decomposes
Flash Point: Not established (solid product)
Solubility: Sparingly soluble in water, soluble in methanol and acetone
Vapor Density: Not applicable
Partition Coefficient: log P = 4.5 (calculated)
Chemical Stability: Stable under recommended storage conditions
Reactivity: Low at room temperature
Conditions to Avoid: Excessive heat, high humidity, strong oxidizers
Hazardous Decomposition Products: Oxides of carbon and nitrogen, toxic fumes in fire
Polymerization: Does not occur
Acute Toxicity: Low oral toxicity in rodents (LD50 oral >2,000 mg/kg)
Inhalation: Can irritate respiratory tract; no chronic data available in humans
Skin Corrosion/Irritation: Mild to moderate irritation possible
Eye Damage/Irritation: Possible mild irritation
Sensitization: May cause allergic reaction upon prolonged or repeated contact
Long-Term Effects: Liver function disturbance (elevated liver enzymes) in some patients
Carcinogenicity/Mutagenicity: Not classified as carcinogen
Reproductive Toxicity: No conclusive studies in humans; possible effects observed in animal models
Aquatic Toxicity: No specific data; prevent large/continuous releases to water bodies
Persistence and Degradability: Not rapidly biodegradable in the environment
Bioaccumulation: Potential exists, though not well characterized
Mobility in Soil: Limited mobility due to low water solubility
Other Adverse Effects: Avoid uncontrolled environmental release
Disposal Methods: Dispose at an approved hazardous waste facility, follow local and national regulations
Container Handling: Triple rinse, then offer for recycling or reconditioning if possible
Precautions: Do not flush to drain or environment; incinerate in a chemical incinerator with afterburner/scrubber for best results
UN Number: Not regulated as a hazardous material
UN Proper Shipping Name: Not regulated (non-dangerous goods by road, air, or sea)
Transport Hazard Classes: None assigned
Packing Group: None
Special Precautions for User: Avoid dust formation and package securely to prevent rupture
US Regulations: Not listed by OSHA, TSCA, CERCLA, SARA; prescription pharmaceutical substance under FDA jurisdiction
EU Regulations: Not classified as a dangerous substance under current EU criteria
Other Classifications: Prescription-only medicine, subject to pharmaceutical and workplace safety regulations in many countries
Label Elements: GHS pictogram, warning label for occupational use, avoid unnecessary handling
