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Product Name: Ribavirin
Synonyms: 1-β-D-Ribofuranosyl-1,2,4-triazole-3-carboxamide
CAS Number: 36791-04-5
Molecular Formula: C8H12N4O5
Molecular Weight: 244.21 g/mol
Manufacturer/Supplier: Contact details of the supplier or manufacturer, including emergency contact number
Recommended Use: Antiviral pharmaceutical agent
Restrictions on Use: For laboratory, research, and industrial use only; not for household or food applications
GHS Classification: Teratogenicity, Specific Target Organ Toxicity
Health Hazards: Causes serious eye irritation, may cause respiratory irritation, may cause reproductive toxicity, may damage the unborn child
Routes of Exposure: Inhalation, skin contact, eye contact, ingestion
Precautionary Statements: Avoid inhalation, prevent skin and eye contact, wash hands thoroughly after handling, wear protective equipment
Signal Word: Danger
Hazard Statements: Toxic if inhaled, harmful if swallowed, suspected of causing genetic defects, may impair fertility
Chemical Name: Ribavirin
Common Name: Ribavirin
Concentration: ≥99% (pure substance)
Impurities: Not significant for hazard
Additional Components: No other ingredients relevant for classification
General Advice: Seek immediate medical attention, show this document to caregivers
Eye Contact: Flush eyes with water for 15 minutes, hold eyelids open, remove contact lenses if present and easy
Skin Contact: Wash with soap and plenty of water, remove contaminated clothing, seek medical help for irritation
Inhalation: Move person to fresh air, keep comfortable for breathing, seek medical help if symptoms develop
Ingestion: Rinse mouth, do not induce vomiting unless directed by medical personnel, seek medical aid
Most Important Symptoms: Irritation to skin, eyes, respiratory tract; possible teratogenic effects
Suitable Extinguishing Media: Use water spray, foam, dry chemical or carbon dioxide
Unsuitable Extinguishing Media: No specific types known
Specific Hazards: Emits toxic fumes (nitrogen oxides, carbon oxides) under fire conditions; fine dust can form explosive mixtures with air
Protective Equipment: Firefighters need self-contained breathing apparatus and full protective gear
Other Information: Cool exposed containers with water spray to prevent pressure build-up or rupture
Personal Precautions: Wear respiratory protection and gloves, prevent contact with eyes and skin, avoid inhalation of dust
Environmental Precautions: Avoid discharge into drains, surface water, soil; contain spillage where possible
Methods for Cleanup: Sweep up using methods that minimize dust generation, transfer to suitable containers for disposal, ventilate area after cleanup, thoroughly wash affected surfaces
Safe Handling: Use only in well-ventilated areas, avoid formation and inhalation of dust, practice good hygiene, keep away from food and beverages
Storage Conditions: Store tightly closed in a dry, cool, well-ventilated place, keep away from incompatible substances such as strong oxidizers, acids, and bases, secure containers to prevent leaks or spills
Incompatible Materials: Strong oxidizing agents, acids, bases
Special Considerations: Avoid contamination, restrict access to trained personnel
Occupational Exposure Limits: No established exposure limit, minimize exposure as low as technically achievable
Engineering Controls: Work in chemical fume hood or with adequate local exhaust, maintain good ventilation in workplace
Personal Protective Equipment: Safety goggles, chemical-resistant gloves (nitrile recommended), lab coat, respiratory protection if potential for aerosol or dust
Hygiene Measures: Wash hands thoroughly after handling, remove contaminated clothing, do not eat, drink, or smoke during use
Appearance: White to off-white crystalline powder
Odor: Odorless
Odor Threshold: Not applicable
pH: Approximately neutral (aqueous solution)
Melting Point: 166–170°C
Boiling Point: Not available
Flash Point: Not applicable
Evaporation Rate: Not applicable
Flammability: Not classified as flammable
Vapor Pressure: Negligible at room temperature
Vapor Density: Not available
Density: 1.55 g/cm³
Solubility: Freely soluble in water
Partition Coefficient (log Kow): -1.85
Auto-Ignition Temperature: Not determined
Decomposition Temperature: Not determined
Chemical Stability: Stable under recommended storage and handling conditions
Reactivity: Nonreactive under typical use and storage
Possibility of Hazardous Reactions: No polymerization anticipated, hazardous decomposition may occur under fire or extreme conditions
Conditions to Avoid: Excessive heat, moisture, incompatible materials
Incompatible Materials: Strong oxidizing agents, acids, bases
Hazardous Decomposition Products: Carbon oxides, nitrogen oxides under combustion
Likely Routes of Exposure: Inhalation, skin contact, eye contact, ingestion
Acute Toxicity: Oral LD50 (rat): >2,000 mg/kg; inhalation LC50 (rat, dust/mist): not available
Chronic Effects: Carcinogenicity not proven in humans, animal data indicate possible reproductive toxicity, may impair fertility, teratogenic effects have been observed in animal studies, potential for causing anemia and bone marrow suppression
Target Organs: Blood, reproductive organs
Symptoms of Exposure: Irritation to respiratory system, eyes, and skin; possible gastrointestinal effects, hematological changes
Sensitization: Not classified as a sensitizer
Mutagenicity: Evidence from animal studies suggests mutagenic potential
Environmental Fate: Limited data; not expected to persist or bioaccumulate due to water solubility and degradation
Aquatic Toxicity: Low acute toxicity expected, specific LC50/EC50 values not readily available
Soil Mobility: Likely to be mobile due to high water solubility
Degradability: Expected to degrade under environmental conditions, rate not quantified
Other Hazards: Not classified as hazardous to the environment, but prudent to prevent large-scale contamination
Waste Treatment Methods: Dispose of contents and container in accordance with local, regional, and national regulations
Waste Disposal: Place in appropriate labeled and sealed containers for hazardous waste disposal, do not discharge into drains or the environment
Incineration: Suitable for chemical waste incineration; consult licensed contractor
Contaminated Packaging: Handle as hazardous waste; triple rinse, puncture, and send to approved waste facility
UN Number: Not regulated as a dangerous good by major international transport regulations (ADR/RID/IMDG/IATA)
Proper Shipping Name: No designated name as non-hazardous for transport
Transport Hazard Class: Not classified as hazardous
Packing Group: Not applicable
Special Precautions: Prevent dust generation and container damage, secure containers during transit
EU Regulation: Classified according to Regulation (EC) No 1272/2008 (CLP); not subject to authorization or restriction
US Regulation: Not listed under US SARA Title III, not regulated under TSCA for commercial use
Canada Regulation: Not subject to WHMIS Classification; listed on the DSL/NDSL
Other Information: Ensure use complies with local occupational health, environmental, and pharmaceutical regulations, provide safety training to personnel handling product
