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Product Name: Resiquimod
Chemical Name: 1-(4-Amino-2-ethylaminopyrimidin-5-yl)-4-(hydroxyethyl)-1H-imidazo[4,5-c]quinoline
CAS Number: 144875-48-9
Molecular Formula: C17H22N6O
Molecular Weight: 326.4 g/mol
Use: Research, immunological studies, experimental drug in oncology and dermatology
Manufacturer Contact: Refer to product packaging for supplier information
Emergency Number: Refer to manufacturer's SDS for emergency contact
Recommended Restrictions: For professional use, not for household or consumer applications
Classification: Skin irritant, Eye irritant, Target organ toxicity (oral, inhalation, dermal exposure)
Hazard Pictograms: Corrosive, Irritant
Signal Word: Warning
Hazard Statements: Harmful if swallowed or inhaled. Causes skin irritation. Causes serious eye irritation. May cause respiratory discomfort.
Precautionary Statements: Avoid breathing dust or particles. Wash hands and exposed skin thoroughly after handling. Wear protective gloves. Wear eye protection.
Unknown Acute Toxicity: Detailed toxicology limited; treat as potentially hazardous to human health.
Substance: Resiquimod
Chemical Identity: 1-(4-Amino-2-ethylaminopyrimidin-5-yl)-4-(hydroxyethyl)imidazo[4,5-c]quinoline
Purity: Greater than 98% (typical for lab-grade material)
Impurities: Trace process-related chemicals, water content varies
Other Ingredients: None indicated on pure chemical sample; check formulation for commercial products
Inhalation: Move person to fresh air, keep comfortable, seek medical attention for persistent symptoms like cough, dizziness, or respiratory distress.
Skin Contact: Remove contaminated clothing, rinse skin thoroughly with water for at least 15 minutes, use soap if available, seek medical advice for irritation.
Eye Contact: Rinse eyes slowly and gently with plenty of water for at least 15 minutes, remove contact lenses if present, keep eyelids open, consult an eye specialist.
Ingestion: Rinse mouth with water, do not induce vomiting, never give anything by mouth if person is unconscious, seek immediate medical attention.
General Guidance: Provide physician with SDS, treat symptoms supportively.
Extinguishing Media: Use water spray, alcohol-resistant foam, dry chemical, or carbon dioxide.
Hazardous Combustion Products: Emits toxic fumes of carbon oxides (CO, CO2), nitrogen oxides during combustion.
Precautions for Firefighters: Wear full body protective gear and self-contained breathing apparatus, avoid inhalation of combustion byproducts, prevent runoff from reaching water bodies.
Fire and Explosion Hazards: Powders may form explosive dust-air mixtures; handle dust with caution.
Personal Precautions: Evacuate area, ventilate if indoors, avoid breathing dust or contacting skin and eyes, restrict access to trained personnel wearing PPE.
Protective Equipment: Use gloves, goggles, lab coat or coveralls, suitable respiratory protection if airborne.
Clean-Up Method: Scoop up material mechanically and place in a sealed non-metallic container, avoid raising dust, wash spill area thoroughly with water and detergent after removal.
Environmental Precautions: Prevent from entering drains, sewers, or water courses, report releases as required by regulations.
Safe Handling: Work in chemical fume hood or well-ventilated area, avoid generating dust, minimize contact with skin, eyes, and clothing, prevent inhalation, wash hands after use, keep containers closed.
Storage Condition: Store at room temperature or as specified by supplier, protect from moisture and direct sunlight, store away from incompatible substances like oxidizers, acids, and bases, store in original container or appropriately labeled container designed for chemicals.
Special Sensitivities: Avoid long-term exposure to air and light, use desiccant in storage container if needed.
Exposure Limits: No occupational exposure limits established. Control airborne concentration as low as reasonably achievable.
Engineering Controls: Use local exhaust ventilation, laboratory hood, and closed processes when possible.
Personal Protective Equipment: Chemical-resistant gloves (nitrile or neoprene), lab coat, safety glasses or chemical splash goggles, NIOSH-approved dust respirator if airborne exposure likely.
Hygiene Measures: Wash hands before eating, smoking, or using restroom; avoid touching face with contaminated gloves; remove and clean contaminated clothing before reuse.
Appearance: Off-white to yellow crystalline powder
Odor: Odorless or faint chemical odor
Odor Threshold: Not determined
pH (Solution): Not available; typically acidic to neutral in water-based solutions
Melting Point/Range: 236-238°C
Boiling Point: Decomposes before boiling
Flash Point: Not applicable/not available
Evaporation Rate: Not applicable
Flammability: Not readily flammable
Vapor Pressure: Not applicable (solid at ambient conditions)
Vapor Density: Not applicable
Relative Density: Not determined
Solubility: Sparingly soluble in water; better in DMSO, methanol
Partition Coefficient (log Kow): Not available
Autoignition Temperature: Not established
Decomposition Temperature: Above 200°C
Viscosity: Not applicable
Chemical Stability: Stable under recommended storage and handling conditions; sensitive to strong acids and oxidizing agents.
Reactivity: Inert under normal laboratory scenarios, incompatible with strong acids, alkalis, strong oxidizers.
Hazardous Decomposition Products: Nitrogen oxides, carbon monoxide, carbon dioxide, other toxic gases may form if heated to decomposition.
Polymerization: Not known to occur.
Special Precautions: Avoid high temperatures, open flames, and incompatible substances.
Routes of Exposure: Inhalation, ingestion, skin, and eye contact.
Acute Toxicity: Harmful by ingestion; data from animal studies suggest LD50 (oral, rat) above 500 mg/kg; no fatal effects at exposure to dilute solution.
Chronic Toxicity: No long-term studies available for repeated or prolonged exposure, potential for chronic effects not excluded.
Skin/Eye Irritation: Risk of moderate to severe irritation in studies with animals; possible reversible eye damage.
Respiratory Sensitization: No sensitization observed in animal models by inhalation.
Carcinogenicity/Mutagenicity/Reproductivity: No adequately designed studies in humans or animals; not listed as carcinogenic by NTP, IARC, OSHA.
Other Effects: Laboratory studies have indicated immune-modulating properties; not for therapeutic use without supervision.
Aquatic Toxicity: Not classified as acutely toxic to aquatic organisms, but avoid discharge into environment.
Persistence and Degradability: Expected to be slowly biodegradable; may persist in aquatic environments.
Bioaccumulative Potential: No significant data; not expected to bioaccumulate based on structure.
Mobility in Soil: Likely to adhere to soil particles, low mobility.
Other Adverse Effects: No evidence of significant environmental impact at laboratory scale; release of larger quantities should be reported.
Disposal Methods: Dispose of unused material and contaminated packaging as hazardous chemical waste according to local, regional, and national regulations.
Incineration: Incineration at high temperature in licensed facility recommended for complete destruction.
Preventive Actions: Do not disperse into environment, avoid sewer disposal, prevent surface and groundwater contamination.
Packing: Materials must be sealed, labeled, and handled by certified waste disposal providers.
UN Number: Not assigned, not classified as hazardous according to transport regulations for road, air, or sea.
Proper Shipping Name: Chemical, not otherwise specified
Transport Hazard Classes: No applicable hazardous classification
Packing Group: Not assigned
Special Precautions: Use sealed containers, avoid damage and spillage, ensure shipment complies with national and international regulations.
Environmental Hazards: Not a marine pollutant under shipping codes; limit release during transport.
Inventory Status: May not appear on all national chemical inventories; research use only in many jurisdictions.
Labeling Requirements: Label as hazardous material in accordance with OSHA HazCom and GHS standards.
SARA Title III: Not subject to specific reporting; not identified as extremely hazardous.
REACH Status (EU): Not registered; intended for research and development only.
WHMIS (Canada): Classified as hazardous according to Canadian regulations; requires workplace labeling.
RoHS/ELV/Other Applicable Legislation: Not specifically regulated for these uses.
Other Regulations: Handle according to all applicable standards; consult up-to-date local, state, and international rules for compliance.
