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Product Name: Ravuconazole
Chemical Name: (2R,3R)-2-(2,4-Difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1,2,4-triazol-1-yl)butan-2-ol
SYNONYMS: E-1224, R-647352
Molecular Formula: C17H15F3N4O
Molecular Weight: 348.32 g/mol
Company Information: Supplier or manufacturer details depend on procurement source.
Recommended Use: Antifungal agent for research or pharmaceutical applications.
Emergency Contact Number: Reference relevant local emergency contact.
Product Code: Internal tracking depends on provider.
Classification: Eye irritation, oral toxicity (category based on available studies), possible respiratory sensitizer.
Signal Word: Warning
Hazard Statements: May cause irritation to eyes, skin, and respiratory tract. Harmful if swallowed.
Precautionary Statements: Avoid breathing dust. Use in well-ventilated areas. Wash thoroughly after handling. Wear protective gloves, clothing, and eye/face protection.
Symptoms of Exposure: Redness, itching of eyes or skin, dry cough.
Other Hazards: No evidence of explosivity or flammability under normal handling conditions.
GHS Label Elements: Exclamation mark icon (for acute toxicity and irritation).
Chemical Name: Ravuconazole
CAS Number: 182760-06-1
Concentration: 98% or greater (research or pharmaceutical grade)
Impurities/Additives: Trace synthesis byproducts, specific to manufacturing process; not significant in reported studies.
Other Ingredients: None expected that contribute to hazard.
Inhalation: Move to fresh air. Get medical advice if symptoms such as sore throat or coughing develop.
Eye Contact: Rinse cautiously with water for at least 15 minutes. Remove contact lenses if present and easy to do. Seek medical attention if irritation persists.
Skin Contact: Wash skin thoroughly with water and soap. Remove contaminated clothing and wash before reuse. Medical attention if rash or irritation develops.
Ingestion: Rinse mouth with water. Get medical help if feeling unwell, do not induce vomiting without medical supervision.
Most Important Symptoms: Signs of local irritation, nausea, dizziness.
Indication of Immediate Medical Attention: Difficulty breathing, persistent coughing, severe eye or skin irritation.
Suitable Extinguishing Media: Water spray, dry chemical, carbon dioxide, foam.
Specific Hazards Arising from Chemical: Emits toxic fumes of nitrogen oxides, fluorinated compounds, and carbon oxides if involved in fire.
Protective Equipment and Precautions for Firefighters: Use self-contained breathing apparatus and full protective gear.
Special Procedures: Prevent run-off from fire control or dilution from entering waterways or drains.
Personal Precautions: Use personal protective equipment including gloves, safety goggles, and lab coat. Avoid generating dust.
Environmental Precautions: Avoid release to environment. Prevent material from entering drains or surface water.
Methods for Cleaning Up: Scoop up, place into appropriate labeled container for disposal. Clean spill site with water and detergent, ventilate area.
Reference Controls: Dispose of cleanup materials according to local laws and regulations.
Handling: Work in fume hood or with local exhaust. Minimize dust creation. Use proper lab technique for transferring powders.
Storage: Store in cool, dry, well-ventilated space, tightly closed in original container. Protect from light and incompatible materials.
Incompatibilities: Avoid strong oxidizers, strong acids or bases.
Special Requirements: Limit quantity in work area. Implement secondary containment for quantities above laboratory scale.
Exposure Limits: No established occupational exposure limits; handle as hazardous chemical.
Engineering Controls: Use chemical fume hood, provide eyewash station and safety shower.
Personal Protective Equipment (PPE): Nitrile or latex gloves, safety goggles, lab coat, respiratory protection for dusty environments.
Hygiene Measures: Do not eat, drink or smoke while using the product. Wash hands before breaks and after handling.
Appearance: White to off-white crystalline powder.
Odor: Odorless.
Odor Threshold: Not applicable.
pH: Not available (not relevant in solid state).
Melting Point: About 180-186°C (reported literature value).
Boiling Point: Decomposes before boiling.
Flash Point: Non-flammable solid.
Evaporation Rate: Not applicable.
Flammability: Not readily flammable.
Vapor Pressure: Negligible at room temperature.
Vapor Density: Not applicable.
Solubility: Poorly soluble in water, soluble in dimethyl sulfoxide (DMSO) and other polar organic solvents.
Partition Coefficient (Log Kow): Approximately 3.4 (estimated).
Auto-ignition Temperature: Not determined.
Decomposition Temperature: >180°C.
Viscosity: Not applicable.
Chemical Stability: Stable under recommended storage and handling conditions.
Possibility of Hazardous Reactions: No polymerization known.
Conditions to Avoid: Direct sunlight, moisture, extreme temperatures.
Incompatible Materials: Strong acids, strong bases, oxidizing agents.
Hazardous Decomposition Products: Nitrogen oxides, fluorinated organic vapors, carbon oxides in fire.
Routes of Exposure: Inhalation, ingestion, skin and eye contact.
Acute Toxicity: Harmful if swallowed (oral LD50 in rodents: 750 mg/kg in rats, referenced from public toxicology sources).
Skin Corrosion/Irritation: Moderate irritation may occur.
Serious Eye Damage/Eye Irritation: May cause eye irritation.
Respiratory or Skin Sensitization: Possible sensitizer in susceptible individuals.
Carcinogenicity: No data indicating carcinoma risk in animals or humans.
Germ Cell Mutagenicity: No mutagenic effects observed in standard tests.
Reproductive Toxicity: No evidence from animal studies of significant reproductive risk under normal conditions of use.
STOT - Single Exposure: May cause irritation to upper respiratory tract.
STOT - Repeated Exposure: Not reported at occupational exposure levels.
Aspiration Hazard: Not expected under normal handling.
Ecotoxicity: Limited aquatic toxicity data available; possible risk to aquatic organisms at elevated concentrations (based on structural similarity to related triazole antifungals).
Persistence and Degradability: Not readily biodegradable in standard tests; chemical expected to persist in environment.
Bioaccumulative Potential: Moderate log Kow suggests potential for bioaccumulation.
Mobility in Soil: Low water solubility limits leaching, adsorption on soil predicted.
Other Adverse Effects: Observe strict procedures to minimize environmental release during use or disposal.
Waste Treatment Methods: Chemical waste requires handling by licensed hazardous waste disposal contractor.
Product Disposal: Do not discharge to sewer systems. Incinerate in chemical incinerator equipped with afterburner and scrubber.
Contaminated Containers: Triple-rinse and dispose of with chemical waste.
Additional Notes: Observe safe chemical handling protocols in compliance with local, regional, national, and international laws.
UN Number: Not regulated for transport under UN, IATA, or IMDG codes.
UN Proper Shipping Name: Not classified as dangerous goods.
Transport Hazard Classes: None.
Packing Group: Not applicable.
Special Precautions for User: Avoid rough handling or excessive vibration, deliver in original container.
Transport in Bulk: Not applicable as product is not for bulk shipment.
US Regulations (OSHA, TSCA): Not listed as hazardous or controlled substance.
EU Regulations (REACH): Not registered; substance handled under research exemption of REACH where applicable.
Other International Regulations: Not listed in Canada DSL/NDSL, Australia AICS, Japan ENCS.
Workplace Classification: Controlled under standard laboratory chemical handling, not subject to specific workplace labeling outside standard hazard communication.
Labelling Requirements: Label containers with contents, hazards, and date of receipt.
Chemical Safety Assessment: Not conducted for small-quantity, research-use chemicals.
Additional Notes: Follow institutional policies for using pharmaceuticals and hazardous substances.
