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Product Name: Ramoplanin
Chemical Formula: C111H179Cl2N30O38
CAS Number: 117928-94-6
Recommended Use: Glycolipopeptide antibiotic used for research and pharmaceutical manufacturing
Manufacturer Details: Refer to your specific supplier’s label
Emergency Telephone: See chemical provider’s emergency contact number
Synonyms: Antibiotic A-16686, Ramoplanin A2
Classification: Non-flammable solid, hazardous to respiratory tract if inhaled, harmful if swallowed, may cause irritation to eyes, skin, and mucous membranes
Signal Word: Warning
Hazard Statements: Causes eye and skin irritation, harmful if inhaled or ingested, may cause allergic respiratory reaction upon repeated exposure
Pictograms: Exclamation mark (irritant), Health hazard
Routes of Exposure: Inhalation, ingestion, dermal contact, eye contact
Precautionary Statements: Use personal protective equipment, prevent dust generation, avoid breathing dust
Chemical Name: Ramoplanin
Concentration: >90% pure
Impurities: Trace amounts of minor fermentation by-products
Other Ingredients: No excipients or carriers in raw solid
Molecular Weight: About 2552 g/mol
Inhalation: Move to fresh air, seek medical attention if symptoms develop, provide oxygen for any breathing difficulty
Skin Contact: Rinse immediately with plenty of water for at least 15 minutes, remove contaminated clothing, get medical help for persistent symptoms
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses if present and easy, keep rinsing, call physician for persistent irritation
Ingestion: Do not induce vomiting, rinse mouth, get immediate medical advice, monitor for allergic reactions
Most Important Symptoms: Irritation, rash, difficulty breathing, allergic response
Suitable Extinguishing Media: Water spray, CO2, dry chemical, foam
Unsuitable Media: Direct water jets may spread powder
Fire Hazards: Organic dust may form explosive air/dust mixtures
Special Protective Equipment for Firefighters: Full protective gear, self-contained breathing apparatus
Hazardous Combustion Products: Carbon oxides, nitrogen oxides, hydrogen chloride, other toxic fumes
Additional Information: Avoid inhalation of smoke or combustion gases
Personal Precautions: Wear gloves, goggles, particulate respirator, avoid contact with skin and eyes
Environmental Precautions: Prevent entry into waterways or drains
Spill Cleanup Methods: Use damp, disposable towels or absorbent material, avoid raising dust, place in suitable container for waste disposal
Large Spill Handling: Evacuate area, ventilate, use HEPA-filtered vacuum if needed
Safe Handling Guidelines: Avoid contact with eyes, skin, and clothing, use in well-ventilated or fume-hood environment, prevent dust formation, maintain good laboratory hygiene
Storage Conditions: Store at -20°C in tightly sealed container, keep away from moisture, oxidizers, incompatible substances
Special Requirements: Segregate from food, animal feeds, incompatible materials
Duration: Maintain at prescribed temperature and container until ready for use
Control Parameters: No established occupational exposure limits for ramoplanin
Engineering Controls: Local exhaust ventilation, safety enclosure or fume hood for weighing and handling powder
Personal Protective Equipment: Lab coat, nitrile gloves, safety goggles, certified respirator for airborne dust
Hygiene Measures: Wash hands after handling, change contaminated clothing, do not eat or smoke near product
Environmental Controls: Prevent discharge into sewer, drains, soil or water body
Appearance: Off-white to pale yellow powder
Odor: Odorless or faint fermentation odor
pH: Not available in solid form, dissolves to neutral-mild acidic
Melting Point/Range: Decomposes before melting
Boiling Point/Range: Not applicable
Solubility: Soluble in DMSO, slightly soluble in water and methanol
Vapor Pressure: Insignificant
Density: Not determined
Flash Point: Not applicable
Partition Coefficient: Not available
Form: Crystalline solid
Chemical Stability: Stable under recommended storage conditions
Reactivity: No hazardous reactivity under normal conditions
Incompatible Materials: Strong oxidizers, strong acids, bases
Decomposition Products: Thermal decomposition may yield carbon oxides, nitrogen oxides, hydrogen chloride
Potential Hazardous Reactions: None known, general risk of dust explosion in presence of ignition source
Acute Toxicity: Harmful by inhalation, ingestion, possible skin absorption
Chronic Toxicity: No confirmed data for humans, animal studies suggest risk for gastrointestinal, hepatic, and renal systems with repeated exposure
Routes of Exposure: Oral, respiratory, dermal, ocular
Symptoms: Cough, throat irritation, nausea, allergic skin reaction
Sensitization: Possible respiratory sensitizer
Carcinogenicity: Not classified by IARC, ACGIH, NTP, or OSHA
Mutagenicity: No available data
Reproductive Toxicity: Data lacking
Aquatic Toxicity: Expected to be toxic to aquatic organisms at low concentrations
Persistence and Degradability: Not readily biodegradable
Bioaccumulation Potential: No data, likely low due to peptide structure
Soil Mobility: No specific data, moderate risk from powder form
Other Adverse Effects: Should not be released into environment, risk of disruption to microbial ecosystems
Waste Disposal Methods: Treat as hazardous pharmaceutical waste, incinerate at approved facility
Contaminated Packaging: Dispose like product waste
Sewage Disposal: Avoid contamination of watercourses and drains
Local/Regional Regulations: Dispose in accordance with local, state, national laws
Precautionary Measures: Do not mix with general waste, label containers appropriately
UN Number: Not assigned
Transport Hazard Class: Non-regulated for transport under most international standards, verify with carrier for specific shipments
Proper Shipping Name: Laboratory chemicals, N.O.S.
Packing Group: Not assigned
Environmental Hazards: Not classified as marine pollutant
Special Precautions: Ship in well-sealed, sturdy containers with cold packs if required
Safety, Health, and Environmental Regulations: Not listed as controlled substance; subject to general workplace safety standards, pharmaceutical and laboratory rules
OSHA: Not specifically listed
EPA: Not registered, but handle as hazardous chemical
EU REACH: Not registered; research use only
TSCA: Not listed for commercial use
Other Regulations: Country-specific rules for laboratories, medical, and research centers apply
Label Elements: Appropriate chemical hazard/biohazard labeling recommended
Training Requirements: Staff handling must be trained in chemical safety, spill response, first aid, personal protection
