© 2026 Sinochem Nanjing Corporation,
All Right Reserved
Product Name: Ramatroban
Chemical Name: 2-[5-(Methylsulfonylamino)-1H-indol-1-yl]benzoic acid
Synonyms: BAY-u3405
CAS Number: 116649-85-5
Manufacturer/Supplier: [Company Name and Address]
Recommended Use: Pharmaceutical research, analytical reference, or synthesis intermediate
Emergency Contact: [Phone Number for Immediate Response]
GHS Classification: Eye irritation (Category 2A), Skin irritation (Category 2), Specific target organ toxicity - single exposure (Category 3)
Hazard Statements: Causes eye irritation. Causes skin irritation. May cause respiratory irritation.
Pictograms: Exclamation mark
Signal Word: Warning
Precautionary Statements: Wash hands thoroughly after handling. Wear protective gloves, clothing, and eye/face protection. Avoid breathing dust, fume, gas, mist, vapors, or spray. Use only outdoors or in a well-ventilated area.
Potential Health Effects: Contact may cause irritation to eyes and skin. Inhalation may cause respiratory tract irritation. Ingestion may result in gastrointestinal discomfort, such as nausea or vomiting. Long-term exposure, as with many pharmaceuticals, presents poorly defined chronic health risks without robust human data.
Chemical Identity: Ramatroban
CAS Number: 116649-85-5
Concentration: 100% (Pure substance for standard laboratory use)
Impurities: None declared in certified reference standard material
Molecular Formula: C19H21N3O4S
Molecular Weight: 387.46 g/mol
Inhalation: Move the person to fresh air immediately. Seek medical attention if symptoms persist, such as difficulty breathing or persistent coughing.
Skin Contact: Remove contaminated clothing and wash affected area with plenty of soap and water. If irritation develops or persists, get medical attention.
Eye Contact: Rinse eyes cautiously with water for several minutes, holding eyelids open. Remove contact lenses if present and easy to do. Continue rinsing. If irritation occurs, contact medical personnel.
Ingestion: Rinse mouth with water; do not induce vomiting unless instructed by medical professionals. Obtain medical advice if unwell or if large quantities have been swallowed.
Most Important Symptoms and Effects: Eye and skin redness, discomfort or pain, throat soreness after inhalation, stomach upsets after ingestion.
Suitable Extinguishing Media: Use water spray, alcohol-resistant foam, dry chemical powder, or carbon dioxide.
Specific Hazards: Can emit toxic fumes under fire conditions, including nitrogen oxides, sulfur oxides, and carbon monoxide.
Advice for Firefighters: Firefighters should wear self-contained breathing apparatus and full protective clothing. Approach fire from upwind to avoid hazardous vapors and decomposition products.
Special Protective Actions: Water runoff may cause environmental contamination; contain fire water and minimize its release to the environment.
Personal Precautions: Use appropriate protective equipment such as gloves, safety goggles, and protective clothing to prevent contact.
Environmental Precautions: Do not allow product to enter drains or watercourses. Avoid release to soil.
Methods for Clean-up: Pick up spilled material with suitable absorbent, such as dry sand or vermiculite. Sweep up and place in a suitable, labeled container for disposal. Ventilate area and wash site after material pickup.
Prevention of Secondary Hazards: Remove all sources of ignition, if present.
Handling: Work only in well-ventilated areas. Avoid inhalation of dust or fumes. Prevent physical damage to containers or packaging. Avoid unnecessary exposure. Do not eat, drink, or smoke in areas where Ramatroban is handled. Minimize dust generation and accumulation.
Storage Conditions: Store in a cool, dry, well-ventilated place, away from incompatible substances such as strong oxidizers or acids. Keep containers tightly closed. Store under inert atmosphere if specified by supplier packaging.
Incompatibilities: Strong oxidizers, strong acids, strong bases.
Engineering Controls: Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommended exposure limits. Maintain an eyewash station and safety shower in the area.
Respiratory Protection: If dust or vapor formation is likely, wear NIOSH-approved respirators.
Hand Protection: Use chemical-resistant gloves (e.g., nitrile or neoprene).
Eye Protection: Wear safety goggles or face shield.
Skin and Body Protection: Wear lab coat or chemical protective clothing.
Hygiene Measures: Wash thoroughly after handling. Remove and wash contaminated clothing before reuse.
Exposure Limits: Not established; handle material with appropriate precautions due to potential sensitizing and irritant effects.
Appearance: White to off-white crystalline powder
Odor: Odorless or faint odor
Odor Threshold: Not determined
pH: Not available
Melting Point: 138–141°C
Boiling Point: Decomposes before boiling
Flash Point: Not applicable
Evaporation Rate: Not available
Flammability: Not classified as flammable
Vapor Pressure: Negligible at room temperature
Vapor Density: Not available
Relative Density: Not available
Solubility: Slightly soluble in water, soluble in DMSO, DMF, and ethanol
Partition Coefficient (Log Pow): Not determined
Autoignition Temperature: Not determined
Decomposition Temperature: Not available
Viscosity: Not available
Chemical Stability: Stable under standard conditions of use and storage.
Reactivity: No specific reactivity hazards under normal handling.
Hazardous Reactions: No dangerous reactions identified under recommended conditions.
Conditions to Avoid: Excess heat, open flames, sources of ignition, direct sunlight, contact with incompatible substances.
Incompatible Materials: Strong acids, strong bases, strong oxidizers.
Hazardous Decomposition Products: Oxides of carbon, nitrogen, and sulfur.
Acute Toxicity: Exact LD50 values not available for oral, dermal, or inhalation exposure; available rodent data suggest low acute toxicity.
Skin Corrosion/Irritation: Causes mild to moderate skin irritation based on similar sulfonamide-containing compounds.
Eye Damage/Irritation: Moderately irritating to eyes.
Respiratory Sensitization: Dust may cause airway irritation.
Skin Sensitization: Known cases are rare; no reliable sensitization data.
Germ-cell Mutagenicity: Not classified as mutagenic based on available studies.
Carcinogenicity: No indication of carcinogenicity in animal models.
Reproductive Toxicity: Data limited for human risk, though animal studies do not indicate strong reproductive hazards.
STOT-Single Exposure: Possible respiratory tract irritation.
STOT-Repeated Exposure: No long-term studies identifying organ toxicity.
Aspiration Hazard: Not classified.
Other Data: Pharmacological effects related to its intended use as a platelet aggregation inhibitor and thromboxane A2/prostaglandin D2 antagonist.
Ecotoxicity: Environmental data limited. Expected to exhibit low toxicity to aquatic organisms based on chemical structure and pharmaceutical profiles.
Persistence and Degradability: Not expected to biodegrade readily.
Bioaccumulative Potential: Low, based on chemical structure; significant accumulation in aquatic organisms is not anticipated.
Mobility in Soil: Limited mobility due to low aqueous solubility.
Other Adverse Effects: Avoid environmental release; material may enter waterways during large-scale spills or improper disposal, where effects remain unknown due to lack of specific studies.
Waste Disposal Methods: Dispose of contents and container in accordance with local, regional, national, and international regulations. Use a licensed chemical disposal contractor if available.
Contaminated Packaging: Decontaminate containers before recycling or disposal, or treat as hazardous waste.
Precautions for Disposal: Do not discharge into drains, soil, or waterways. Incineration is preferred for pharmaceutical waste.
UN Number: Not regulated for transport
UN Proper Shipping Name: Not a hazardous substance according to transport regulations
Transport Hazard Class: None assigned
Packing Group: None assigned
Environmental Hazards During Transport: No significant hazard on a small laboratory scale; take usual precautions to avoid physical damage, spills in transit, or combined shipment with incompatible substances.
Special Precautions: Keep container tightly sealed and upright. Clearly label packages for shipping with appropriate hazard designations.
Safety, Health, and Environmental Regulations/Legislation Specific to the Substance: Not listed as a controlled or hazardous substance by major regulatory agencies, including OSHA, TSCA, or WHMIS.
Chemical Inventories: Not required to be listed for pharmaceutical research use.
Other Regulatory References: Comply with any workplace-specific requirements in the country of use, including handling practices and exposure standards established by local authorities.
Additional Classification: Not subject to reporting under SARA Title III or California Proposition 65 as of last update.
