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Watching how medicines come to market often reveals more about society’s priorities than anything. Racecadotril’s story started in France during the 1980s, at a time when the world focused on treating symptoms rather than causes. Researchers in European labs noticed how standard anti-diarrheal drugs worked by slowing gut movement, leading to uncomfortable or even dangerous side effects in children. Racecadotril took a different route: it worked on enzymes, especially enkephalinase. Instead of binding everything up, it supported the body’s natural balance. Soon, clinicians saw the value, especially for treating acute diarrhea in children—a major global health concern. By the mid-1990s, several countries in Europe and Latin America adopted the drug as a safer option compared to opioid derivatives like loperamide. Over time, India and parts of Asia added it to their lists too. Reading old papers, you’ll notice physicians heaving a sigh of relief: finally, a pediatric option offering solid safety, without the risk of toxic megacolon.
Racecadotril, sometimes called acetorphan, belongs to the class of antidiarrheal medications. Instead of targeting pathogens directly, it blocks the breakdown of enkephalins. These are natural peptides helping regulate water and electrolyte flow in the intestines. Available in capsule, granule, and suspension formulations, racecadotril comes meant mainly for short courses during bouts of acute diarrhea. Every time you open a packet of the powder, the light odor resembles that faint whiff in chemistry labs, a reminder of its thioester content. In terms of commercial names, you’ll see brands like Hidrasec and Tiorfan across markets—names that nod to its action or molecular backbone. As a consumer, I always notice how instruction leaflets walk a fine line: clear on use, direct about staying hydrated, but careful not to overpromise.
Chemically, racecadotril stands out due to its thioester group and peptide-like structure. Its chemical formula is C21H23NO4S, giving it a moderate molecular weight just under 400 daltons. In its pure state, the drug presents as a white or faintly yellow crystalline powder. The melting point typically hovers around 108–110°C. Water solubility remains low, owing to both aromatic rings and the thioester, so most oral preparations require excipients or solvents to get the powder to disperse. The logP value, indicating lipid solubility, results in decent oral absorption but keeps blood-brain barrier penetration minimal. Reading through lab reports, I’ve noticed pharmacists tend to appreciate its stability: stored away from moisture, it resists degradation better than many other peptide derivatives. The powder has no notable taste, but many formulations add a bit of sweetness for pediatric use, since the bitterness can come through at higher doses.
Regulatory agencies expect a high level of detail on racecadotril labels. Boxes get marked with the dose—often 10 mg for infants, 30 mg for older children and adults—alongside the route of administration. Information about excipients, batch number, and expiry date are standard; packaging includes warnings about use in children under three months old or in cases of chronic diarrhea. Pharmacists rely on the shelf-life, usually stated as three years under normal conditions, as a guide to their stock rotation. Labels emphasize the importance of continued hydration and sometimes include basic ORS (oral rehydration solution) instructions. The specifications list not only the active ingredient purity, which sits at above 99% by HPLC, but also a series of impurity limits and storage instructions. Box inserts in certain geographies, especially France and India, include clinical trial data summarizing outcomes against loperamide to back regulatory approval.
Raw racecadotril owes its existence to a multi-step organic synthesis. The route usually starts from L-phenylalanine derivatives, which chemists acylate, then couple to a thioester intermediate. Peptide bond formation, using standard activation chemistries like carbodiimides, gets followed by hydrolysis under mild acidic conditions. High-yield routes avoid harsh reagents, since the thioester can break down or rearrange easily. In major production plants, reaction vessels operate under nitrogen, and the temperature curve gets tightly controlled—any misstep can create unwanted byproducts. After synthesis, purifying the bulk involves both crystallization and solvent washes to strip away polar and non-polar contaminants. Sometimes, additional chiral resolution steps are necessary, since the enantiomeric purity must meet strict pharmaceutical standards. Reading descriptions from process chemists, the phrase “keep it dry, keep it cool” comes up over and over—the thioester moiety loves to hydrolyze if given a chance.
Modifying racecadotril for research or analog development means tinkering with the thioester or substituting side chains on the benzyl group. Adding electron-withdrawing substituents to the aromatic rings can shift oral bioavailability and enzyme affinity. Swapping out the thioester for thioamide or carboxylate changes both metabolic stability and distribution. Researchers often use racemic mixtures during primary SAR (structure-activity relationship) screens before separating out the active enantiomer. In lab notebooks, the breakdown reaction—the hydrolysis of the thioester to a mercaptan and carboxylic acid—shows up as the most critical side reaction to monitor. Attempts to make prodrugs, or extended-release versions, usually glue a different acyl group onto the active core. Academics tracking metabolite profiles have mapped out the transformation to the main circulating form, S-acetylthiorphan, which does most of the pharmacological heavy lifting in vivo.
Pharmaceutical literature lists several names: acetorphan (its international nonproprietary name), and the various commercial brands. In my experience, the market splits mainly between Hidrasec in Europe and Tiorfan in France, while Indian companies push different generics under local licensing deals. In regulatory filings, you’ll typically find the CAS number 81110-73-8 attached to active ingredient specs, along with synonyms like N-(2-Benzyl-1-oxothiolan-3-yl)glycine benzyl ester. Older pharmacology texts sometimes use the code number “BTD-9,” a relic from early-stage trials in the 1980s. Having to look up all these aliases in reference books always reminds me how fragmented pharmaceutical nomenclature can get.
Racecadotril’s long-established clinical track record makes it a comfort for many pediatric and adult clinicians. Typical side effects look mild: headache, skin rash, or nausea. Nearly every review points out the absence of constipation, which sets it apart from loperamide. Pharmacovigilance systems in Europe and Latin America haven’t flagged anything alarming, though rare hypersensitivity reactions do appear in the literature. Most manufacturers follow strict GMP (Good Manufacturing Practice) regulations, with focus on preventing cross-contamination and accurate dosing—critical for pediatric products. On the pharmacy side, drug-drug interaction screens seldom turn up problems, as the mechanism stays confined to the gut. I’ve seen that with light handling (goggles, gloves, dust mask) lab staff face little risk; racecadotril isn’t volatile nor does it cause skin reactions in most cases. Regulators ask for disposal in keeping with peptide waste guidance, given the molecule’s stability and lack of environmental persistence.
Hospital wards and family clinics in many countries rely on racecadotril for quick relief during outbreaks of viral gastroenteritis. It’s most used for children with acute watery diarrhea, but it sees some use among adults during food poisoning episodes or travel-related tummy trouble. In places with limited access to IV fluids or advanced care, its safety margin matters a lot. I’ve watched rural doctors welcome alternatives to codeine- or diphenoxylate-based treatments, since those can depress breathing, especially in young kids. In Europe, racecadotril stands out as the top prescription for post-surgical diarrhea and as an adjunct to rehydration therapy. In rare cases, clinical teams reach for it during tube-feeding in post-surgical patients because it doesn’t alter gut motility, so it won’t hinder nutrition plans. Oral cavity-friendly preparations mean even toddlers can handle a dose, unlike chalky tablets.
Pharma research into enkephalinase inhibitors keeps uncovering potential tweaks to the racecadotril molecule. Scientists aim to boost oral absorption or slow metabolic breakdown, hoping for new candidates in chronic diarrhea or even irritable bowel syndrome. Lab groups have created analogs with tighter receptor selectivity, then tested them in animal models; some show promise for inflammation-driven diarrhea, which marks a big change from early studies. The focus also turned to combination tablets pairing racecadotril with probiotics or zinc—this combination sees interest in South Asian and African trials. Clinical research tracks both monotherapy and adjuvant applications, comparing rates of return to normal stool and hospital admission numbers. I’ve noticed competitive studies pitting racecadotril against not just loperamide, but also newer peptide drugs and herbal remedies. Digital health projects now use real-world prescribing data to drive smarter clinical algorithms, nudging physicians toward safer choices for kids.
Toxicology data pile up over decades, and racecadotril looks good on paper and in practice. Acute dosing in rats and dogs brings no concerning findings, with LD50 values far above therapeutic doses. Long-term tests exposed no evidence of mutagenesis or carcinogenesis. Special focus gets placed on pediatric safety: chronic exposure studies in young animals simulate worst-case scenarios, looking for liver, kidney, or brain changes. Reports note only minor alterations at doses many times higher than human equivalents—usually reversible after a washout period. Genomic screens show racecadotril and main metabolites steer clear of DNA-damaging potential. Human case reviews reinforce the animal findings; no consistent signal for harm appears in pooled data or case series. In hospitals, poison control notes little toxicity even in accidental double doses, provided rehydration stays on track. This has cemented its spot on several ‘essential medicines’ lists, especially in resource-strapped regions.
Racecadotril’s established position leaves room for both generics expansion and clinical innovation. Patent cliffs opened the door for India, Brazil, and Southeast Asia to build local manufacturing pipelines, broadening access. Ongoing research plays with new salt forms, hoping for easier dispersal in drinks or faster onset. There’s growing talk of extending use to chronic diarrhea, post-op cases, or targeted therapy in HIV-associated enteropathies—a sharp break from the notion that it belongs only in the pediatric aisle. As more researchers profile gut microbiome shifts alongside symptom relief, the aim is clearer understanding of secondary benefits. Public health bodies—backed by World Health Organization support—look to get racecadotril into rural clinics worldwide, using centralized procurement and training campaigns for health workers. Eventually, the molecule’s simplicity and stable safety promise open doors to more fixed-dose combinations, smarter pediatric dosing, and digital tracking of outcomes. As countries step up their fight against diarrheal disease, a proven tool like this stands ready to save both money and lives, with room still to grow through generics, better delivery tech, and coordinated care models.
Racecadotril just doesn’t come up during the average family dinner. It definitely should, though, if anyone has ever wrestled with persistent diarrhea, either as a parent worried about a child or an adult coping with gut issues. People usually think of loperamide or bismuth subsalicylate for these gut problems, but Racecadotril works differently. It belongs to a class called enkephalinase inhibitors—science words that basically mean it stops the body from breaking down natural substances that help keep water in the gut. This means less water lost, stools that aren’t as runny, and a body that stays hydrated.
One bout of diarrhea probably won’t send anyone to the hospital, but things can get dangerous fast if it drags on. Especially for kids or older adults. In places where access to clean water or speedy healthcare isn’t a sure thing, dehydration from diarrhea isn’t just uncomfortable—it can be fatal. That’s why safe and effective ways to manage diarrhea matter far beyond simple comfort. Racecadotril reduces the loss of water and electrolytes during each episode, which takes huge pressure off anyone trying to handle dehydration at home or in a crowded clinic.
Loperamide, a big name in most medicine cabinets, slows the movement of the gut so stool takes longer to come out. That can help, but it can also trap bacteria or toxins inside the gut. With kids, there’s more risk than reward much of the time. Racecadotril doesn’t slow down gut movement, so the body still clears out unwelcome guests. It only works on how much water the gut releases. Several studies show it shortens diarrhea in children without making them constipated or groggy. Europe and parts of Asia consider it a go-to medicine for young patients
Working as a pharmacy tech, parents bring their kids in looking desperate for anything that works better than homemade soup and oral rehydration salts. Old advice still counts: most diarrhea gets better with fluids and rest. But I’ve seen relief on parents’ faces when they hear about a medicine that won’t block the gut, won’t cause drowsiness, and gives their child a break from being stuck on the toilet all day. Racecadotril fills that role in countries where it’s available as granules or capsules. It’s always been a challenge explaining to parents why a medicine isn’t yet available everywhere, but clarity and transparency matter during stressful times.
Doctors need up-to-date options, yet medication habits change slowly. Racecadotril isn’t sold everywhere, and most folks won’t see it on a shelf in the United States. With any medicine, cost, access, and clear education make a difference in health outcomes. Drug-resistant infections and the risks of overusing traditional antidiarrheals keep rising. It makes sense to look carefully at medicines like Racecadotril and push for studies that help patients and parents trust what’s offered. Open conversations matter: explaining how a medicine works, who should take it, who shouldn’t, and what to watch for—these basics go a lot further than fancy packaging or buzzwords. Trusted advice from healthcare workers makes the most difference at the end of the day.
Diarrhea hits hard and fast. Most people reach for loperamide or run to their doctor for instructions. In recent years, though, Racecadotril, known in some countries as Hidrasec, emerged as an alternative. I came across this medicine through firsthand experience working at a pharmacy, where parents and travelers picked it up, wanting something gentler than the options they knew.
This medicine stands out by controlling secretions in the gut without blocking how things move along the intestines. The gut produces fluids to help break down food. During an infection or irritant, the body goes into overdrive and loses electrolytes through excessive fluid secretion. Loperamide, which everyone knows, slows gut movement down but often leaves you with that uncomfortable bloating. Racecadotril, on the other hand, focuses on the cause.
Racecadotril works by blocking an enzyme called enkephalinase. This enzyme usually breaks down enkephalins, which are chemicals that limit fluid secretion in the intestines. By stopping that enzyme, Racecadotril lets these natural substances stick around and do their work. Less fluid ends up in the gut, which leads to fewer watery stools, but the gut keeps moving like usual.
Real-life experience tells a different story from brochures and drug rep visits. People using Racecadotril rarely complain about cramping or rebound constipation. Studies back this up. Children and adults both benefit, with data showing quicker symptom relief and fewer episodes compared to placebo. No one wants to trade one problem for another—Racecadotril respects that.
A study published in the journal Gastroenterology found that Racecadotril reduced the duration and amount of diarrhea in children by about a day. Side effects stack up low compared to many common medications, with rare reports of mild rashes and headaches. The World Health Organization recommends this medicine in several guidelines for managing acute watery diarrhea, especially in children.
Nobody wants a medicine that leaves you chained to the bathroom or bloated at work. I’ve seen parents relieved when their kids’ stomach issues get managed without additional misery. Travelers worry less about being locked up in a hotel room. One important truth is that people often forget about oral rehydration, which is vital. Racecadotril doesn’t replace the need for proper hydration. The best outcomes come when it’s used with oral rehydration salts, especially in young children.
Health workers need to stay aware of limitations. Racecadotril brings relief but doesn’t solve chronic or severe infections like cholera or dysentery. If there’s blood in the stool or high fever, care goes straight to a doctor, not just the medicine cabinet. Over-the-counter use has grown, and pharmacists and nurses should watch for misuse, especially in places where infectious diarrhea spreads easily.
Better education fixes more than a prescription pad. People need tools to tell when a simple diarrhea problem crosses the line. Racing to new solutions like Racecadotril is only half the journey. That includes reinforcing the basics—clean water, handwashing, and quick access to rehydration treatment. In the end, the right medicine often makes the hard days easier, but common sense and prevention always matter most.
Racecadotril earns its spot in the medicine cabinet as a remedy for diarrhea. Doctors trust it for children and adults because it slows down water and salt loss in the gut without shutting the system down. This relief comes with a tradeoff. No medicine leaves the body untouched, and side effects can show up even with careful use.
Stomach pain sits near the top of racecadotril’s list of common side effects. People often feel a mild stomach discomfort, or sometimes experience bloating and nausea. These don’t necessarily mean the medicine isn’t working. Most of the time, these symptoms pass within a few days, especially if people stay hydrated and eat light meals.
Some people end up with a skin rash. This reaction pulls a red flag immediately, since any rash from a new medication could be a sign of an allergy. The most experienced doctors advise stopping the drug if a rash appears and checking for swelling, itching, or any problems breathing. Those signs can point to a severe allergic reaction. Stories from clinics in Europe and Asia back this up: most side effects run mild, but rare allergic responses need quick medical attention.
Children can react a bit differently from adults. Pediatricians have warned that some kids develop a runny nose or cough after a few doses. This matches reports from parents who see these symptoms in toddlers starting medication. Research from pediatric studies shows a small number might even get red eyes or fever. In my own practice, the parents most concerned tend to be those with kids using racecadotril for the first time. Open conversations about what to look for help ease the anxiety and catch issues early.
Clinical data from over a decade shows racecadotril stays on the safer side compared to older anti-diarrheal drugs like loperamide, which can cause constipation and, in rare cases, dangerous bowel blockages in children. Published studies in journals like the Journal of Pediatric Gastroenterology and Nutrition highlight a low rate of serious side effects, with less than 3% of users reporting problems, and even fewer needing to stop the medicine.
Still, the rare risks matter. Doctors have documented cases where prolonged use, particularly among the elderly or the very young, brings new problems. Dehydration can creep up faster in these groups since diarrhea itself already drains fluids. No medication can fully replace fluids lost, so oral rehydration solutions stay crucial alongside racecadotril.
Doctors play the biggest role by selecting racecadotril carefully and warning about red flags—rash, severe stomach pain, or signs of dehydration like dry mouth or few wet diapers. Pharmacists help by double-checking for allergies and explaining the signs of rare side effects. Families can help by watching for anything out of the ordinary, including changes in energy or mood. Hydration tips, easy access to safe drinks, and choosing foods gentle on the gut all support recovery and lower risk.
Continued research gives a clearer map of who benefits most and who faces added risk. More real-world studies could focus on vulnerable groups. Medical teams keep updating their advice every year so racecadotril remains a tool for treatment—never a reason for worry.
Racecadotril steps into the picture during spells of diarrhea, easing discomfort by targeting the chemicals in the gut that drive out excess fluids. Many folks reach for this medicine during bouts of acute diarrhea to cut down on stool volume and frequency—without risking the kind of dehydration that comes with over-the-counter antidiarrheals like loperamide.
Unlike medicines that slow the intestines to a crawl, Racecadotril keeps digestion rolling at its own pace. The active ingredient blocks an enzyme called enkephalinase, which increases natural gut chemicals that rein in water loss. Fewer stomach cramps, less rush to the bathroom, fewer side effects.
Doctors and pharmacists typically recommend Racecadotril in capsule, granule, or powder form. Adults usually go with the capsules, taken before meals with a sip of water. For young children, granules or suspensions work best. Working in pharmacy, I learned the trick lies in matching the dose to the child’s actual weight for best results. Too little, and symptoms drag on; too much, and you risk lowering water in the gut too much.
Side effects don’t turn up often with Racecadotril. Still, folks sometimes report rashes or mild tummy trouble. Severe reactions rarely happen, but always keep an eye open in young children or those with allergies.
Common mistakes pop up more than you’d expect: Skipping doses, doubling up after missing, mixing with hot liquids, or not shaking suspensions enough. Each mistake wastes the medicine’s potential and invites trouble. For little ones, parents sometimes misjudge a dose, thinking a quick fix will get life back on track. Diligent dosing brings both effectiveness and safety.
Racecadotril doesn’t handle dehydration—oral rehydration solution remains the backbone of treatment. Children with ongoing vomiting, fever, or blood in the stool need a visit with the pediatrician. Adults shouldn’t see diarrhea lasting longer than a few days without further checks.
I always tell people to stick with the dosing schedule on the pharmacy label. Set reminders on your phone. Ask for a demonstration on mixing suspensions; even seasoned caregivers make mistakes. If you live with someone elderly or a child who can’t swallow capsules, ask your pharmacist about alternatives. Bringing leftover medicine to the pharmacy for disposal keeps things safe, too.
Quality information matters as much as the medicine. It’s important to ask the pharmacist questions, report rashes, and insist on clear directions. Look for reliable sources: regulatory health websites like the FDA or EMA, local poison control centers, and pharmacists trained to spot red flags.
Racecadotril can be a lifesaver during travel, daycare outbreaks, or sudden illness at home. Safety grows from careful dosing, watching symptoms, and using proper hydration. Problems with medicine use often come down to poor communication, rushed explanations at the pharmacy, or skipping the leaflet in the box. I’ve seen parents relieved when clear instructions wipe away fear or confusion. That’s the kind of confidence you want—knowledge that makes a tough day better, not worse.
Racecadotril gets prescribed for kids battling diarrhea, especially in parts of the world where the condition takes a toll on daily life and family routines. Manufacturers market it as a medicine that slows down fluid loss in the gut, promising fewer watery stools without putting a brake on the natural gut movement. The product doesn’t touch the body like antibiotics do; instead, it targets the problem right in the digestive system. Families, especially those who have seen toddlers doubled over with stomach pain, often seek solutions that don’t come with too many side effects.
Researchers have published their observations in respected medical journals. They point out that racecadotril, used for short periods in children over three months, reduces stool output and doesn’t come with increased constipation, drowsiness, or abnormal gut habits. European and Asian health authorities have approved it for use in children. French guidelines include it as a treatment option, alongside oral rehydration. Doctors who have used it in clinics say most children tolerate it well, with allergic reactions or rashes showing up rarely.
Looking at published clinical trials, adverse effects don’t jump out when compared with sugar pills. Yet, science always deals with real-life cases, and some kids do experience mild skin rashes or vomit. These numbers stay low, unlike the side effects linked to some other antidiarrheal drugs. The most trusted pediatricians still emphasize hydration before and during racecadotril therapy, as this medicine can stop diarrhea but does not replace lost fluids.
Parents deserve every honest fact, especially where kids’ health is concerned. Some companies may overstate improvements, so digging into evidence remains key. The World Health Organization doesn’t put racecadotril on its essential medicines list, pointing out that oral rehydration and zinc cover the basics for most children with diarrhea. Overuse of any medicine, or skipping basic treatments, only muddles recovery.
Relying solely on medicine like racecadotril brings risks. Children who keep vomiting or are too weak to drink may not benefit, and danger signs like blood in the stool, high fever, or dehydration need hospital care instead of over-the-counter solutions. In rare situations, using multiple anti-diarrheal drugs together causes gut blockages or worsens infection—pediatricians warn against mixing treatments without careful guidance.
Every parent knows the stress of watching a child lose energy and fluids. Seeking quick fixes feels natural, but the basics—plenty of fluids, rest, and small meals—remain proven. Racecadotril may fit as an extra tool, not a starting point. Where oral rehydration doesn’t seem enough and a doctor recommends it, the safety track record supports its careful use. Pharmacy shelves can’t replace advice from a qualified pediatrician, and no medicine should become the first answer for every upset stomach.
Staying informed and open to updates in guidelines, backed by lived experience in homes and clinics, builds trust. Parents who know the real strengths and limits of each treatment help kids recover faster and avoid unnecessary risks.
| Names | |
| Preferred IUPAC name | (RS)-N-(2-benzyl-3-(1-oxothiolan-3-yl)propanoyl)glycine |
| Other names |
Hidrasec Tiorfan Tiorfix Zorix Redotril |
| Pronunciation | /ˌreɪsəˈkædətrɪl/ |
| Identifiers | |
| CAS Number | 81110-73-8 |
| Beilstein Reference | 136217 |
| ChEBI | CHEBI:75104 |
| ChEMBL | CHEMBL1649 |
| ChemSpider | 86367 |
| DrugBank | DB11643 |
| ECHA InfoCard | ECHA InfoCard 100000704392 |
| EC Number | EC 3.4.14.5 |
| Gmelin Reference | 319290 |
| KEGG | D08102 |
| MeSH | D018833 |
| PubChem CID | 6918270 |
| RTECS number | UY2325000 |
| UNII | K4I6E2G7FT |
| UN number | UN number: "UN3469 |
| Properties | |
| Chemical formula | C21H23NO4S |
| Molar mass | 529.629 g/mol |
| Appearance | White or almost white powder |
| Odor | Odorless |
| Density | 1.46 g/cm³ |
| Solubility in water | Practically insoluble in water |
| log P | 2.2 |
| Vapor pressure | 4.32E-11 mmHg at 25°C |
| Acidity (pKa) | 10.11 |
| Basicity (pKb) | 4.71 |
| Magnetic susceptibility (χ) | -65.8×10^-6 cm^3/mol |
| Refractive index (nD) | 1.64 |
| Dipole moment | 3.25 D |
| Thermochemistry | |
| Std molar entropy (S⦵298) | 354.6 J·mol⁻¹·K⁻¹ |
| Std enthalpy of formation (ΔfH⦵298) | -407.2 kJ/mol |
| Std enthalpy of combustion (ΔcH⦵298) | -1606 kJ/mol |
| Pharmacology | |
| ATC code | A07XA04 |
| Hazards | |
| Main hazards | May cause hypersensitivity reactions, gastrointestinal disturbances, and headache. |
| GHS labelling | GHS07, GHS08 |
| Pictograms | 💊🌊💩✋ |
| Signal word | Warning |
| Hazard statements | Hazard statements: H302 |
| Precautionary statements | P102 Keep out of reach of children. P501 Dispose of contents/container in accordance with local/regional/national/international regulations. |
| NFPA 704 (fire diamond) | NFPA 704: 1-1-0 |
| Flash point | 126.2°C |
| Lethal dose or concentration | LD50 = 528 mg/kg (Rat, oral) |
| LD50 (median dose) | 'Racecadotril LD50 (median dose): 1100 mg/kg (oral, rat)' |
| NIOSH | NQ927J56BL |
| PEL (Permissible) | 500mg |
| REL (Recommended) | 100 mg |
| IDLH (Immediate danger) | No IDLH established |
| Related compounds | |
| Related compounds |
Thiorphan Acetorphan Ecadotril |
