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Product Name: Raceanisodamine
Synonyms: Racemic Anisodamine; 1,2,3,4-Tetrahydro-6-hydroxy-1-(1-methyl-3-oxo-2-pyrrolidinyl)-3-isoquinolinecarboxylic acid methyl ester
CAS Number: 522-79-4
Recommended Use: Pharmaceutical intermediate, research chemical
Manufacturer Information: Supplied by major pharmaceutical ingredient manufacturers, typically under regulated conditions; contact specific distributor for emergency and technical information
Emergency Contact: National Poison Control and manufacturer’s emergency number
GHS Classification: Acute toxicity (oral, dermal), Eye irritation, Skin irritation
GHS Label Elements: Signal word: Warning; Pictograms: Exclamation mark
Hazard Statements: Harmful if swallowed; causes skin and eye irritation
Precautionary Statements: Wear protective gloves/clothing, avoid inhalation and ingestion, wash thoroughly after handling
Most Significant Hazards: High-dose exposure linked to anticholinergic effects, including dry mouth, tachycardia, blurred vision, confusion, and central nervous system disturbances
Chemical Identity: Raceanisodamine
Chemical Formula: C17H21NO4
Molecular Weight: 303.36 g/mol
Purity: Typically >98% (varies with manufacturer)
Impurities: Not expected to contain hazardous levels of impurities under approved manufacturing conditions
Inhalation: Move to fresh air. Seek medical attention if symptoms persist. Respiratory distress or severe exposure requires medical monitoring due to anticholinergic toxicity.
Skin Contact: Wash with soap and water for at least 15 minutes. Remove contaminated clothing and seek medical advice for irritation or allergic reaction.
Eye Contact: Rinse cautiously with water for several minutes, lifting remote eyelids as needed. Remove any contact lenses, continue rinsing, and seek immediate medical attention.
Ingestion: Rinse mouth with water, do not induce vomiting. Seek emergency medical support immediately as anticholinergic effects may develop rapidly.
Special Notes for Physicians: Monitor for signs of anticholinergic syndrome; treat with supportive care and consider antidotes such as physostigmine if appropriate.
Suitable Extinguishing Media: Water spray, dry chemical, foam, or carbon dioxide. Choose media appropriate for adjacent substances.
Hazardous Combustion Products: Nitrogen oxides, carbon monoxide, carbon dioxide, other unidentified toxic vapors
Advice for Firefighters: Wear full protective gear, including self-contained breathing apparatus. Minimize exposure to smoke and fumes.
Unusual Fire Hazards: Powder can form explosive dust clouds in the air, avoid generation of dust during fire-fighting measures.
Personal Precautions: Wear personal protective equipment such as gloves, lab coat, safety glasses, and an approved dust mask in poorly ventilated areas. Evacuate unnecessary personnel from the area.
Environmental Precautions: Prevent runoff to streams, sewers, and other water sources. Notify local authorities in the event of environmental contamination.
Methods for Containment and Cleanup: Scoop up material without generating dust, place in a tightly sealed container for disposal. Clean affected surfaces with detergent and ample water, ventilate the area well.
Handling: Use inside approved fume hood or well-ventilated space. Minimize dust generation and airborne exposure. Do not eat, drink, or smoke while handling.
Storage: Store in cool, dry, and well-ventilated area away from heat sources and incompatible chemicals (e.g., strong oxidizers). Use tightly closed, labeled containers. Restrict access to trained personnel.
Special Storage Requirements: Protect from direct light and moisture. Segregate from incompatible substances and inspect containers regularly for leaks.
Engineering Controls: Use local exhaust ventilation, process enclosures, or other engineering controls to maintain airborne levels below recommended limits.
Personal Protection Equipment: Wear chemical-resistant gloves, safety goggles or face shield, lab coat or equivalent body protection. Use an approved particulate respirator in cases of inadequate ventilation.
Exposure Limits: No specific occupational exposure limits established; control exposure as low as possible based on potential toxicity.
Hygiene Measures: Wash hands and exposed skin thoroughly after handling, change out of contaminated clothing before leaving the work area.
Appearance: White or off-white crystalline powder
Odor: Odorless
pH: Not applicable/Not available
Melting Point: Approximately 124-126°C
Boiling Point: Not determined for this compound
Solubility: Soluble in water, ethanol, and organic solvents
Density: Not established for bulk solid
Vapor Pressure: Negligible under ambient conditions
Partition Coefficient (log Pow): Not reported
Flash Point: Not available
Auto-ignition Temperature: Not available
Explosive Properties: Fine dust may pose explosion risk if dispersed in air
Chemical Stability: Stable under recommended storage conditions
Reactivity: No hazardous reactivity expected under normal handling
Conditions to Avoid: Heat, open flames, sources of moisture, strong oxidizing agents
Incompatible Materials: Oxidizers, acids
Hazardous Decomposition Products: May generate nitrogen oxides and carbon oxides during combustion or thermal decomposition
Acute Toxicity: Harmful if swallowed, inhaled, or absorbed through skin; LD50 values (oral-rat) range between 240-400 mg/kg (data varies); significant toxicity through the central and peripheral nervous systems
Chronic Toxicity: Repeated high doses may cause cumulative anticholinergic effects, including confusion, hallucinations, ataxia
Skin/Eye Irritation: Causes irritation; risk increases with direct and prolonged contact
Additional Information: Individuals with pre-existing health conditions (cardiac arrhythmias, glaucoma, prostatic hypertrophy) could experience heightened susceptibility and adverse effects
Carcinogenicity/Mutagenicity: No long-term carcinogenicity data available; not classified as carcinogen under current standards
Ecotoxicity: Data not widely available; pharmaceutical chemicals can disrupt aquatic microflora and fauna at trace levels
Persistence and Degradability: Not readily biodegradable; risk of persistence in aquatic environments
Bioaccumulative Potential: Not expected to bioaccumulate significantly in organisms
Mobility in Soil: Moderate to low due to solubility characteristics; more likely to partition into water than soil
Other Adverse Effects: Risk to aquatic organisms increases in case of large accidental release, consider advanced treatment for industrial wastewater containing residual product
Waste Treatment Methods: Treat as hazardous pharmaceutical waste; hand over to licensed waste disposal contractor
Product Disposal: Do not release to sewers or environment, incinerate in approved facility if possible
Contaminated Packaging: Decontaminate before recycling if allowed by regulations or dispose as hazardous material
Regulatory References: Consult national, regional, and local waste disposal regulations for pharmaceutical products and laboratory chemicals
UN Number: Not regulated under international transport codes for limited research quantities
Proper Shipping Name: Pharmaceutical product, not otherwise specified
Transport Hazard Class: None assigned for limited quantities
Packing Group: None assigned
Environmental Hazards: Not a marine pollutant in standard packaging
Special Precautions: Secure packaging to avoid damage, prevent accidental release during transportation, ensure containers remain tightly sealed and labeled
International Regulations: Not listed on major chemical control schedules (e.g., US TSCA, EU REACH) for broad industrial use. Use for research or pharmaceutical supply governed by regional drug approval agencies.
OSHA Status: Not listed as hazardous chemical, but applies requirements for laboratory safety for toxicants
WHMIS Classification: Not controlled under Canadian WHMIS regulations but handle as a hazardous laboratory substance
Inventory Status: May not appear on chemical inventories; subject to control due to use in drug manufacture
Other Regulations: Comply with local and national chemical safety requirements, including hazardous communication standards and health and environmental protection guidelines
