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Substance Name: Quinine Sulfate Dihydrate
Chemical Formula: C20H24N2O2·H2SO4·2H2O
SYNONYMS: Quinine dihydrate sulfate, Quinine hemisulfate dihydrate
CAS Number: 6119-70-6
Recommended Use: Pharmaceutical raw material, antimalarial agent, laboratory chemical
Manufacturer Details: Supplier and manufacturer name and address with emergency contact number
GHS Classification: Acute Toxicity (Oral, Dermal, Inhalation) Category 4; Eye Irritation Category 2
Signal Word: Warning
Hazard Statements: Harmful if swallowed, inhaled, or absorbed through skin. Causes serious eye irritation. May cause respiratory tract irritation.
Pictograms: Exclamation mark
Precautionary Statements: Avoid breathing dust. Wash hands thoroughly after handling. Do not eat, drink, or smoke while using this product. Wear protective gloves, eye protection, and face protection. Keep container tightly closed.
Chemical Name: Quinine Sulfate Dihydrate
Concentration: >98% (by weight)
CAS Number: 6119-70-6
Impurities: Water < 3%, Sulfate ions, trace organic compounds
Additives: No additional hazardous components present above reporting limits
Eye Contact: Immediately flush eyes with plenty of water for at least 15 minutes, lift eyelids occasionally, seek medical attention
Skin Contact: Wash exposed area with soap and copious amounts of water, remove contaminated clothing, seek medical help for persistent irritation
Inhalation: Move to fresh air, if not breathing give artificial respiration, get medical attention if symptoms develop or persist
Ingestion: Rinse mouth, do not induce vomiting, give water if victim is conscious, obtain medical advice promptly
Most Important Symptoms: Nausea, vomiting, headache, visual disturbances, tinnitus, dizziness, skin rash possible following exposure
Note to Physicians: Treat symptomatically, monitor for cardiac and neurological effects, supportive care recommended
Suitable Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or foam
Unsuitable Media: Do not use a direct water stream as it may scatter powder
Specific Hazards: Combustion produces toxic fumes such as nitrogen oxides, sulfur oxides, carbon monoxide
Protective Equipment: Wear self-contained breathing apparatus, full fire-fighting protective gear, avoid inhalation of combustion products
Fire Fighting Instructions: Isolate area, prevent runoff, keep cool all containers exposed to flames with water spray
Personal Precautions: Use suitable protective equipment, avoid formation and inhalation of dust, ventilate area
Environmental Precautions: Prevent entry into drains, sewers, surface and ground water
Cleanup Methods: Sweep up carefully, avoid generating dust, transfer to appropriate waste containers, wash spill area with water
Disposal: Dispose of in accordance with local, regional, and national environmental regulations
Handling Procedures: Avoid contact with skin, eyes, and clothing, minimize dust generation, handle in well-ventilated areas, do not eat, drink, or smoke during use
Storage Conditions: Store in original, tightly sealed container, keep in cool, dry, and well-ventilated location, away from incompatible materials such as strong oxidizers and acids
Incompatibilities: Strong oxidizing agents, strong acids, bases
Storage Temperature: Room temperature, avoid extreme heat or cold
Exposure Limits: No established occupational exposure limits (consult local, regional limits where available)
Engineering Controls: Use local exhaust ventilation, laboratory fume hood
Personal Protective Equipment (PPE): Safety goggles, chemical-resistant gloves (nitrile or neoprene), laboratory coat, protective footwear
Respiratory Protection: NIOSH-approved dust respirator if concentrations exceed recommended limits or during large-scale usage
Hygiene Measures: Wash hands thoroughly after handling, remove contaminated clothing and launder before reuse, avoid contact with food and drink
Appearance: White to almost white, crystalline powder
Odor: Odorless
Molecular Weight: 782.95 g/mol
Melting Point: 218-222°C (decomposes)
Solubility: Slightly soluble in water, practically insoluble in chloroform and ether, soluble in acids
pH (1% Solution): 2.5–3.5
Boiling Point: Not applicable (decomposes on heating)
Vapor Pressure: Negligible
Partition Coefficient (log Pow): 3.2
Other Characteristics: Stable under recommended storage conditions, hygroscopic in nature
Stability: Chemically stable under normal conditions
Hazardous Reactions: Reacts with strong oxidizing agents, generates toxic fumes under fire conditions
Decomposition Products: Nitrogen oxides, sulfur oxides, carbon monoxide, carbon dioxide on combustion
Polymerization: Does not occur
Other Information: Sensitive to moisture, avoid prolonged exposure to light, heat, and air
Routes of Exposure: Inhalation, ingestion, skin and eye contact
Acute Toxicity: Oral LD50 (mouse): 660 mg/kg; Oral LD50 (rat): 641 mg/kg
Chronic Effects: Repeated exposure may affect heart, kidneys, liver, blood, and nervous system
Symptoms: Headache, nausea, blurred vision, ringing in ears, CNS depression, allergic skin reaction
Carcinogenicity: Not classified as carcinogenic by IARC, NTP, OSHA
Other Health Effects: May cause hematological changes, ECG changes at high doses
Reproductive Toxicity: Limited evidence of fetotoxic effects at high doses
Ecotoxicity: Harmful to aquatic life, toxicity to bacteria and algae reported in literature
Persistence and Degradability: Not readily biodegradable, partial persistence expected
Bioaccumulative Potential: Moderate potential due to organic structure and solubility
Mobility in Soil: Low; binds strongly to soil matrices
Other Hazards: Avoid discharge into environment, long-term effects in aquatic systems possible
Waste Disposal: Dispose of material and container through licensed disposal contractor
Small Quantities: Dilute with copious water and flush to drain where permitted by regulations
Large Quantities: Collect in leak-proof containers for incineration or chemical combustion under controlled conditions
Packaging Disposal: Empty containers must be triple-rinsed and disposed according to local guidance
Precautions: Avoid contamination of soil, water, and drains during disposal
UN Number: Not regulated as hazardous for transport (check regional/national changes)
Proper Shipping Name: Quinine Sulfate Dihydrate
Hazard Class: Not applicable for standard quantities
Packing Group: Not assigned
Labeling: Not required for non-bulk shipments
Special Transport Precautions: Protect containers from physical damage, moisture, and direct sunlight during transit
Additional Information: Always check for updates on transport requirements as rules evolve
TSCA: Listed on the United States Toxic Substances Control Act inventory
ECHA (REACH): Registered, restrictions may apply according to intended use
OSHA Hazards: Harmful if swallowed, inhaled, or absorbed
FDA: Approved drug component, subject to prescription guidelines
Canada WHMIS: D2B (toxic materials causing other toxic effects)
Other Inventories: Listed on Australian AICS, New Zealand NZIoC, Japanese ENCS
Labeling Requirements: GHS-compliant labels, hazard pictograms, and precautionary statements must always remain visible on containers
