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Product Name: Pyrimethamine
Chemical Name: 5-(4-chlorophenyl)-6-ethyl-2,4-pyrimidinediamine
CAS Number: 58-14-0
Synonyms: Daraprim, Gulfahrer, Kelfizina
Recommended Uses: Antiparasitic, antiprotozoal agent targeting malaria and toxoplasmosis
Supplier Details: Manufacturer address and emergency contact must be provided on each sheet, including 24-hour hotline.
Classification: Harmful if swallowed, risk of allergic respiratory or skin reaction, potential target organ toxicity
Signal Word: Warning
Hazard Statements: Toxic to aquatic life, possible carcinogen based on studies, may cause central nervous system depression
Symbol(s): Exclamation Mark, Health Hazard
Precautionary Statements: Avoid inhalation and ingestion, prevent release to the environment, use personal protective equipment
Routes of Exposure: Ingestion, inhalation, skin and eye contact
Potential Health Effects: Nausea, headache, dizziness, rash, allergic reaction, affects blood cell production
Component: Pyrimethamine
CAS Number: 58-14-0
Proportion: Typically ranges from 98% to 100% as supplied for laboratory and pharmaceutical use
Impurities: Trace solvents or byproducts may occur from synthesis process, always referenced in manufacturer certification
Inhalation: Remove person to fresh air, support breathing with oxygen if needed, seek medical advice immediately
Skin Contact: Wash affected area with soap and water, remove contaminated clothing, monitor for persistent irritation
Eye Contact: Rinse with water for 15 minutes, keep eyelids open, get medical evaluation as soon as possible
Ingestion: Do not induce vomiting, rinse out mouth, seek urgent medical care, show chemical container/label to attending physician
Most Important Symptoms: Gastrointestinal upset, cyanosis, anemia due to folic acid antagonism, potential convulsions at high doses
Suitable Extinguishing Media: Dry chemical powder, carbon dioxide, foam, avoid direct water jet
Special Hazards: Produces toxic fumes of nitrogen oxides and carbon oxides during combustion
Protective Equipment: Firefighters need self-contained breathing apparatus, gloves, complete protective clothing
Firefighting Advice: Isolate hazard area, prevent run-off, ventilate confined spaces after fire, beware of flammable dust in air
Personal Precautions: Evacuate unnecessary personnel, use personal protective equipment including respirator, eye protection, gloves
Environmental Precautions: Prevent spillage from entering drains, waterways, or soil, contain with inert absorbent material
Spill Cleanup: Sweep or scoop up without raising dust, transfer to labelled container, dispose as hazardous waste, ventilate area thoroughly
Decontamination: Wash spill site after material pickup complete, avoid splashing or dust generation
Precautions for Handling: Use in well-ventilated area, avoid inhaling dust or vapors, no eating or drinking near chemical
Hygiene Measures: Wash hands and exposed skin thoroughly after handling, remove contaminated clothing immediately
Storage Conditions: Keep container tightly closed in dry, cool, well-ventilated location, protect from light
Incompatible Materials: Strong oxidizers, bases, acids, keep away from food and beverages
Storage Temperature: Recommended between 15°C and 25°C, away from moisture
Occupational Exposure Limit: No established workplace limit, handle as hazardous substance
Engineering Controls: Local exhaust ventilation, fume hood for laboratory use, maintain negative room pressure
Personal Protection: Chemical resistant gloves, safety goggles, lab coat, approved respirator for dust/mist
Environmental Controls: Prevent release to surface water or waste systems, use secondary containment where possible
Appearance: White to yellowish crystalline powder
Odor: Odorless
Molecular Weight: 248.71 g/mol
Solubility: Slightly soluble in water, soluble in ethanol and chloroform
Melting Point: 232-234°C
Boiling Point: Decomposes before boiling
pH: Not applicable (solid, but forms weakly basic aqueous solution)
Vapor Pressure: Negligible
Partition Coefficient (log Pow): 2.5 (approximate data)
Other Data: Stable under normal handling, sensitive to strong acids and bases
Chemical Stability: Stable under normal temperatures and pressures, decomposes at high temperature
Conditions to Avoid: Excessive heat, open flames, light exposure, moisture
Hazardous Reactions: No hazardous polymerization, reacts vigorously with strong oxidizing agents
Decomposition Products: Nitrogen oxides, carbon monoxide, carbon dioxide
Acute Toxicity: Oral LD50 (rat) 350 mg/kg
Symptoms of Overexposure: Nausea, vomiting, ataxia, convulsions, bone marrow suppression
Chronic Toxicity: Risk of megaloblastic anemia, leukopenia from folate deficiency
Carcinogenic Effects: No classified as carcinogen by OSHA, IARC, NTP; long-term risks not fully established
Reproductive Toxicity: May harm fetus due to interference with folate metabolism
Other Effects: Possible liver and kidney stress at high exposure
Ecotoxicity: Highly toxic to aquatic organisms, acute and chronic exposure can disrupt local ecosystems
Mobility: Limited mobility in soil due to low water solubility, tends to bind to sediment
Persistence and Degradability: Slow degradation in the environment, may persist in aquatic settings
Bioaccumulation: Potential for accumulation in aquatic species; monitoring advised
Waste Treatment Methods: Dispose in accordance with local, state, federal regulations as hazardous pharmaceutical waste
Container Disposal: Triple wash, deface label, send for chemical incineration
Additional Precautions: Avoid discharge to landfill or sewage, keep documentation of disposal record
UN Number: Not regulated as hazardous for ground, air, or marine transport
Proper Shipping Name: Pyrimethamine
Transport Hazard Class: None assigned
Packing Group: Not applicable
Special Precautions for User: Prevent breakage or leaks during transportation, seal in primary and secondary containers
International Status: Listed in European, US, Japanese, and Canadian chemical inventories
OSHA Status: Considered hazardous under OSHA criteria
TSCA: Listed
WHMIS (Canada): Class D2B – Toxic material causing other toxic effects
REACH Status (EU): Registration under process, restrictions may apply for pharmaceutical and research use
Labeling Requirements: GHS and local jurisdictional hazard statements, pictograms, warnings per chemical safety standards
