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Product Name: Pyridostigmine Bromide
Chemical Formula: C9H13BrN2O2
Synonyms: 1,2,3,6-Tetrahydro-1-(dimethylcarbamoyloxy)pyridine bromide
CAS Number: 101-26-8
Intended Use: Diagnostic reagent, chemical synthesis, pharmaceutical ingredient for treatment of myasthenia gravis
Manufacturer Name: Provided on supplier documentation
Contact Information: Emergency phone numbers located on supplier safety sheet
GHS Classification: Acute toxicity (oral), skin irritation, eye irritation, specific target organ toxicity
Hazard Pictogram: Skull and crossbones (acute toxicity), exclamation mark (irritant)
Signal Word: Danger
Hazard Statements: Toxic if swallowed, causes skin and eye irritation, may cause respiratory issues if inhaled
Precautionary Statements: Do not eat, drink or smoke during use; wash hands thoroughly after handling; avoid breathing dust; wear protective gloves and eye protection
Chemical Name: Pyridostigmine Bromide
Chemical Formula: C9H13BrN2O2
Concentration: ≥98% by weight
Impurities and Stabilizing Additives: None classified as hazardous
Inhalation: Move individual to fresh air; monitor breathing; provide oxygen if breathing is difficult; seek urgent medical advice
Ingestion: Rinse mouth immediately; do not induce vomiting; call poison control and get immediate medical assistance
Skin Contact: Remove contaminated clothing; thoroughly wash skin with water and soap for at least 15 minutes; seek medical help if irritation or symptoms develop
Eye Contact: Rinse eyes carefully with plenty of water for at least 15 minutes, holding eyelids apart; remove contact lenses if present and safe to do; obtain prompt medical evaluation
Suitable Extinguishing Media: Water spray, dry chemical, foam, carbon dioxide
Special Hazards Arising From Substance: Hazardous gases such as nitrogen oxides, hydrogen bromide, carbon oxides could release on combustion
Advice for Firefighters: Wear self-contained breathing apparatus and full protective gear; evacuate area; use water spray to cool containers exposed to fire
Explosion Data: Not sensitive to mechanical impact or static discharge
Personal Precautions: Avoid inhalation of dust; wear respiratory protection, gloves, and protective eyewear
Environmental Precautions: Prevent release to drains, surface waters, and soil; isolate spill area
Methods for Clean-Up: Collect spilled material using non-spark tools or HEPA vacuum; sweep and scoop into labeled container for disposal; decontaminate area with suitable cleaning agent
Handling: Use in ventilated area; avoid dust generation; wear protective clothing and respirator if needed; observe hygiene practices by washing hands after handling
Storage: Keep container tightly closed in dry, well-ventilated space; separate from food, water, and incompatible chemicals; label containers clearly; control temperature to avoid degradation; restrict access to authorized personnel only
Exposure Limits: No established ACGIH or OSHA limits; minimize exposure to dust
Engineering Controls: Local exhaust ventilation; process enclosure; emergency eyewash stations and safety showers
Personal Protective Equipment: Chemical-resistant gloves (nitrile or neoprene); safety goggles or face shield; lab coat or apron; P3 particulate respirator if risk of dust; avoid open-toed shoes; use proper glove removal technique to avoid skin contact
Appearance: White to off-white crystalline powder
Odor: Odorless
Melting Point: 153–156°C
Boiling Point: Decomposes before boiling
Solubility: Easily dissolves in water
pH: Neutral to slightly acidic (5–6 in 1% solution)
Vapor Pressure: Negligible at room temperature
Density: 1.6 g/cm³
Partition Coefficient: Not determined
Chemical Stability: Remains stable under recommended storage conditions
Conditions to Avoid: Excess heat, light, moisture
Incompatible Materials: Strong oxidizing agents, strong bases
Hazardous Decomposition Products: Hydrogen bromide gas, nitrogen oxides, carbon monoxide, carbon dioxide
Hazardous Polymerization: Does not occur
Acute Toxicity: Oral LD50 (rat): 18 mg/kg
Skin Corrosion/Irritation: Causes moderate irritation
Eye Damage/Irritation: Irritates eyes
Respiratory Sensitization: Inhalation of dust may lead to respiratory tract irritation
Chronic Effects: Prolonged exposure may affect nervous system, manifesting as muscle twitching, abdominal cramps, or respiratory depression
Carcinogenicity: No evidence from long-term studies
Mutagenicity: Not classified as mutagenic
Reproductive Toxicity: Not classified as reproductive toxicant
Ecotoxicity: Harmful to aquatic life; may disrupt aquatic organisms if released in large quantities
Persistence and Degradability: Likely to degrade in environment with time, but may persist under some conditions
Bioaccumulative Potential: Low potential for bioaccumulation
Mobility in Soil: High solubility increases mobility; can migrate to groundwater
Other Adverse Effects: No evidence of ozone degradation or global warming risk
Waste Treatment Methods: Dispose in accordance with local, regional, and national regulations for hazardous waste
Contaminated Packaging: Rinse thoroughly and offer for chemical recycling or incineration where allowed
Methods of Disposal: Do not release material to environment; use licensed waste contractor; segregate from general refuse
UN Number: 3249
Proper Shipping Name: Medicine, solid, toxic, n.o.s. (Pyridostigmine Bromide)
Transport Hazard Class: 6.1 (Toxic substances)
Packing Group: III
Transport Regulations: Subject to IATA, IMDG, and ADR requirements for toxic substances. Secure packaging, clear labeling, and transport paperwork are required
Marine Pollutant: Not listed as marine pollutant
Inventory Status: Listed under US TSCA, EU REACH
Labeling Requirements: Contains hazardous material; GHS and local regulations demand hazard pictograms, signal words, and risk statements
Other Regulations: CLP Regulation (EU), OSHA Hazard Communication Standard, WHMIS (Canada), SARA Title III (USA) indicate hazardous potential; imported quantities may face restriction or reporting
Workplace Limits: Employers to enact risk management measures and provide staff training for handling toxic substances as per occupational safety rules
