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Product Name: Prothioconazole
Chemical Name: 2-[2-(1-chlorocyclopropyl)-3-(2-chlorophenyl)-2-hydroxypropyl]-1,2-dihydro-3H-1,2,4-triazole-3-thione
CAS Number: 178928-70-6
Recommended Use: Fungicide for agricultural applications
Manufacturer: Leading agrochemical producers, including contact and emergency numbers
Synonyms: None well known in commercial use
Emergency Contact: Supplier hotline, local poison control center
Hazard Classification: Acute toxicity (Category 4, Oral), Skin sensitizer (Category 1), Environmental hazard for aquatic life (Category 1)
Signal Word: Warning
Hazard Statements: Harmful if swallowed, may cause allergic skin reaction, toxic to aquatic organisms, may cause long-lasting harmful effects to aquatic environments
Pictograms: Exclamation mark, environmental hazard symbol
Precautionary Statements: Wash hands thoroughly after handling, avoid release to environment, wear protective gloves and eye protection, avoid breathing dust or spray
Routes of Exposure: Inhalation, skin contact, ingestion, eye contact
Target Organs: Skin, gastrointestinal tract, eyes, respiratory system
Chemical Substance: Prothioconazole
Concentration: Technical active substance typically 98% or higher in pure product; lower concentrations in formulated products
Impurities: Trace solvents, inert carriers, surfactants and wetting agents depending on formulation
Other Ingredients: Water, thickening agents, dispersants, safeners (varies by manufacturer and product form)
Formulation Types: Suspension concentrate, emulsifiable concentrate, granules or wettable powders (ingredient specifics vary by formulation)
Inhalation: Remove person to fresh air, keep comfortable for breathing, seek medical attention if symptoms like coughing or shortness of breath persist
Skin Contact: Remove contaminated clothing, rinse skin gently with plenty of soap and water for at least 15 minutes, seek medical advice for persistent irritation
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses if present and easy, continue rinsing, get medical attention if irritation develops
Ingestion: Rinse mouth, do not induce vomiting, seek immediate medical attention or contact a poison center, never give anything by mouth to an unconscious person
General Advice: Show physician the product label or this sheet, follow guidance for accidental exposure
Suitable Extinguishing Media: Dry chemical, carbon dioxide, water fog, alcohol-resistant foam
Unsuitable Media: High-pressure water jets which may scatter the substance
Specific Hazards: Hazardous decomposition products such as hydrogen chloride, nitrogen oxides, sulfur oxides, and other toxic gases possible when burning
Protective Equipment for Firefighters: Full protective clothing and self-contained breathing apparatus recommended
Firefighting Procedures: Move containers away from fire if safe, contain runoff to prevent entry into water courses or drains, cool exposed containers with water spray
Explosion Hazards: Not known to be explosive but closed containers may rupture if heated
Personal Precautions: Wear suitable protective equipment including gloves, goggles, coveralls, and suitable respiratory protection
Environmental Precautions: Prevent entry into drains, surface water, or ground water, contain spill with sand, earth, or other inert absorbent
Methods for Clean-Up: Scoop or sweep up into a sealable container, avoid creating dust, clean area thoroughly with water and detergent, dispose of according to local regulations
Emergency Procedures: Evacuate unnecessary personnel, ventilate area, alert appropriate authorities for large spills
Decontamination: Wash spill area thoroughly, avoid direct contact with skin and eyes
Handling: Use in well-ventilated area, prevent skin and eye contact, avoid inhalation of vapors or sprays, use recommended PPE
Storage Conditions: Store locked up in original container tightly closed, well labeled, cool and dry storage (<30°C), keep away from food, drink, and animal feed
Incompatible Materials: Strong oxidizers, acids and bases, avoid storing near sources of ignition or heat
Hygiene Measures: Wash hands and exposed skin before eating, drinking, smoking, or leaving work area
Exposure Limits: No specific occupational exposure limits set for prothioconazole (consult country regulations)
Engineering Controls: Use local exhaust ventilation, process enclosures and equipment isolation for handling or mixing
Personal Protective Equipment: Impervious gloves (nitrile or neoprene), long-sleeved shirts and pants, chemical goggles or face shield, NIOSH-approved respirator for dust or vapor if relevant
Environmental Controls: Use procedures and equipment to contain runoff, detect and fix leaks quickly, waste management protocols in place
Appearance: White to off-white crystalline solid (technical); may appear as fluid, powder, or granule in different commercial forms
Odor: Mild, characteristic or slightly sulfurous
Odor Threshold: Not determined or not available
pH: 5.5 to 8.5 in water suspension
Melting Point: 91-93°C
Boiling Point: Decomposition before boiling
Flash Point: Not highly flammable
Evaporation Rate: Not determined
Flammability: Not classified as flammable
Vapor Pressure: 1.1 x 10⁻⁶ Pa at 20°C
Water Solubility: 62 mg/L at 20°C
Partition Coefficient (Log Pow): 3.7
Decomposition Temperature: >180°C
Viscosity: Not determined
Bulk Density: 1.4 g/cm³ (powder form typical)
Chemical Stability: Stable under normal recommended conditions of storage and handling
Reactivity: Not reactive under normal use conditions
Conditions to Avoid: Excess heat, open flame, moisture, direct sunlight
Materials to Avoid: Strong acids, bases, oxidizing agents
Hazardous Decomposition Products: Hydrogen chloride, sulfur dioxide, nitrogen oxides, carbon monoxide and dioxide
Polymerization: Does not undergo hazardous polymerization
Acute Toxicity (Oral LD50 rat): Approximately 620 mg/kg
Acute Dermal Toxicity (rat): >2000 mg/kg
Acute Inhalation Toxicity (rat): >5.5 mg/L (4 h, dust/aerosol)
Skin Corrosion/Irritation: Mild to moderate irritation in lab animals, risk of sensitization with repeated or prolonged exposure
Serious Eye Damage/Irritation: Mild eye irritation reported
Respiratory Sensitization: No conclusive data but prudent to avoid inhalation
Carcinogenicity: No evidence of carcinogenic effects in long-term rodent studies
Mutagenicity: Negative in standard testing
Reproductive Toxicity: No adverse effects observed at standard doses in animal studies
Chronic Effects: Possible allergic reactions; no significant evidence for mutagenicity, teratogenicity or developmental toxicity at recommended exposures
Eco-toxicity (Fish LC50): 5.8 mg/L (96 h, rainbow trout)
Aquatic Invertebrate (Daphnia EC50): 2.8 mg/L (48 h)
Algae EC50: 2.5 mg/L (72 h, growth rate, green algae)
Bacteria IC50: 16.1 mg/L (activated sludge respiration test)
Soil Microorganism Impact: No significant disruption in recommended use patterns
Bird Toxicity (LD50): >2000 mg/kg (mallard duck)
Bioaccumulation: Moderate bioconcentration possible, log Pow suggests potential for accumulation
Persistence/Degradability: Moderately persistent, soil DT50 from lab studies approx. 38 days
Mobility in Soil: Moderately mobile, risk for leaching into ground water considered low under good agricultural practice
Product Disposal: Dispose via licensed hazardous waste contractor or incineration in accordance with local, regional, and national regulations
Container Disposal: Triple rinse empty containers, puncture and offer for recycling or disposal in a sanitary landfill, follow local requirements
Waste Management: Never pour unused product down drains or waterways, prevent runoff to surface water, comply with crop and environmental protection guidelines
UN Number: 3077
Proper Shipping Name: Environmentally hazardous substance, solid, n.o.s. (prothioconazole)
Transport Hazard Classes: 9 (Miscellaneous dangerous substances and articles)
Packing Group: III
Environmental Hazards: Yes (substance hazardous to the aquatic environment)
Special Precautions: Mark package with marine pollutant symbol when transported by sea, avoid direct contact or release during transport
Regulatory References: Complies with IMDG, IATA, ADR/RID standards for hazardous chemicals by transport route
Global Inventories: Listed or compliant in major chemical inventories (TSCA, EINECS, DSL, PICCS, NZIoC, AICS, etc.)
Label Requirements: Pesticide labeling under national regulatory agency guidance (EPA in US, ECHA in EU, others by country)
Workplace Requirements: Comply with OSHA Hazard Communication Standard, EU REACH, local occupational health and safety laws
Restrictions: Restricted use in certain countries for particular crop or environmental protection mandates
SARA Title III (Section 313): Not subject to specific reporting
Other Regulations: Application subject to buffer zone and water protection policies; use subject to maximum allowable residue levels in food and feed crops as set by local or national agencies
