© 2026 Sinochem Nanjing Corporation,
All Right Reserved
Product Name: Neutral Protease
Synonyms: Protamex, Neutral Proteinase
CAS Number: 9001-92-7
Recommended Use: Enzymatic processing, protein hydrolysis, laboratory research
Supplier Details: Bulk enzyme suppliers, research chemical distributors, address and emergency contact available on purchase
Product Form: Powder or liquid, depending on procurement source
EMERGENCY Phone Number: Found on supplier label and accompanying documentation, generally available 24 hours
Classification: Not classified as hazardous under GHS, but respiratory and skin sensitization risks exist
Health Hazards: Inhalation of dust can trigger allergic reactions or asthma in sensitive individuals, contact may cause rash or irritation
Physical Hazards: No significant physical hazards under standard storage and handling, but dust can be an irritant
Environmental Hazards: Large spills may alter local biochemistry in waterways by excessive protein breakdown
Label Elements: Pictogram: Exclamation mark for irritant
Signal Word: Warning
Hazard Statement: May cause respiratory irritation or allergic reaction
Precautionary Statement: Use respiratory protection and gloves, avoid unnecessary exposure, especially to dust
Main Component: Neutral Protease, typically >95% enzyme protein
Source: Produced from Bacillus species via fermentation
Impurities: Minor fermentation byproducts, trace stabilizers possibly present below 1%
Inactive Ingredients: Moisture (3–7% by mass), some preparations may contain trace buffer salts for stability
Chemical Formula: Not a single compound, mixture of peptide sequences forming active protein
Inhalation: Move individual to fresh air, supply oxygen if breathing shows difficulty, seek medical attention for persistent symptoms
Skin Contact: Wash thoroughly with soap and water, remove contaminated clothing, apply skin moisturizer if irritation persists
Eye Contact: Rinse eyes promptly with water for 15 minutes, keep eyelids open, seek care if discomfort remains
Ingestion: Rinse mouth, drink water, do not induce vomiting, call physician if large quantities consumed
Most Important Symptoms: Wheezing, rash, redness, sore throat, possible delayed skin sensitization in repetitive exposure
Immediate Medical Attention: Needed for severe respiratory response or allergic reaction
Suitable Extinguishing Media: Use dry chemical powder, foam, carbon dioxide, or fine water spray
Specific Hazards: Combustion releases carbon oxides, nitrogen oxides, possibly irritating protein fumes
Special Protective Equipment: Firefighters need self-contained breathing apparatus, full turnout gear to avoid inhaling enzyme dust
Hazardous Combustion Products: Acrid smoke, protein degradation vapors, possibly small quantities of toxic gases
Additional Notes: Remove product containers from fire area if safe
Personal Precautions: Wear appropriate respirator, gloves, and goggles to prevent inhalation and skin contact
Spill Response: Avoid generating dust, ventilate area, sweep up with minimal agitation using dampened tools or HEPA vacuum
Cleanup: Place collected material in sealed container for disposal, wash spill site with soap and water
Environmental Precautions: Prevent entry into drains or waterways
Reporting Requirements: Not regulated for minor spills, but large spills call for local authority notification
Handling: Wear PPE including dust mask, long sleeves, and goggles in workplace, avoid eating or drinking in handling areas
Hygiene Measures: Wash hands before breaks and after touching protease, use local exhaust ventilation if dust forms
Storage: Keep in tightly sealed containers at 2–8°C, shielded from humidity and direct sun
Incompatibilities: Avoid storing with strong oxidizers or acids, segregate from food and feed items
Shelf Life: Stability maintained for 12–24 months under recommended conditions
Exposure Limits: No established occupational exposure limits, minimize exposure as much as practical
Engineering Controls: Use fume hood, process enclosure, or local exhaust to reduce airborne dust
Personal Protective Equipment (PPE): Respirator (N95 minimum) if dust risk, protective gloves (nitrile recommended), safety glasses or face shield, lab coat
Skin Protection: Barrier cream can provide extra defense for sensitive skin
Work Practices: Change contaminated clothing, use good housekeeping to limit dust build-up
Appearance: Fine off-white to pale yellow powder, commercial liquid forms may be clear to straw-colored
Odor: Mild, proteinaceous
pH (1% solution): Between 6.5 and 8.5
Solubility: Soluble in water, forms slightly turbid solution
Melting Point: Not applicable, decomposes before melting
Boiling Point: Not applicable to proteinaceous solids
Flash Point: Not flammable under normal circumstances
Bulk Density: 0.3–0.6 g/cm³
Decomposition Temperature: Above 60°C protein denaturation begins, breaks down rapidly
Chemical Stability: Stable at recommended storage conditions, activity drops rapidly above room temperature or in humidity
Reactivity: Reacts with strong oxidizing agents, acids may denature protein and inactivate enzymatic activity
Hazardous Reactions: None known under normal processing and storage
Decomposition Products: Thermal breakdown produces standard protein fumes, trace amines
Incompatible Materials: Avoid strong acids, strong oxidizers, heavy metal salts like copper or mercury
Acute Toxicity: Oral LD50 in animals not precisely established, considered low toxicity based on protein nature
Routes of Exposure: Inhalation, skin, eye, and ingestion
Symptoms: Eyes and respiratory system most vulnerable, can cause redness, watering, cough, shortness of breath; repeated skin contact traps enzyme and leads to eczema
Chronic Effects: Repeated inhalation causes respiratory allergies, occupational asthma in rare cases
Carcinogenicity, Mutagenicity, Reproductive Toxicity: Not classified as carcinogen, no evidence for mutagenicity or reproductive risk in studies to date
Ecotoxicity: Enzymes degrade naturally, but high concentrations local to discharge boost oxygen demand and can disturb balance in smaller water systems
Aquatic Toxicity: Direct toxicity to aquatic life considered low, issue relates to biochemical oxygen demand (BOD) if large amounts released
Persistence and Degradability: Degrades quickly in soil and water, proteins broken down by natural microflora
Bioaccumulative Potential: Not expected to bioaccumulate, protein splits into amino acids, rapidly used by microorganisms
Mobility in Soil: Moderately mobile, moves with water, quickly bound by soil particles
Waste Treatment Methods: Small amounts can go to municipal landfill or sewer with permission, dilute before disposal
Larger Quantities: Collect in sealed containers, dispose of through licensed chemical waste contractor
Precautions for Disposal: Avoid dust creation, do not incinerate in open areas
Contaminated Packaging: Triple rinse, then follow local regulations for disposal or recycling
Regulatory Status: Not classified as hazardous waste by most agencies, confirm with regional environmental authorities
UN Number: Not regulated as dangerous good under UN, ADR, IATA
Proper Shipping Name: Neutral protease preparation
Transport Hazard Class: None assigned
Packing Group: Not assigned
Special Precautions: Protect packages from moisture, extreme heat, and rough handling
Labeling: General labeling as "Enzyme Preparation", precautionary info visible for logistics handlers
Global Inventories: Listed on TSCA (USA), EINECS (EU), AICS (Australia), ENCS (Japan)
OSHA, WHMIS Status: Not classified as hazardous, but may trigger workplace respiratory protection and allergen labeling
GHS Labeling: Signal word "Warning", risk of allergy and irritation indicated
Other Regulations: Transport, storage, and safety rules vary by country, check local requirements if importing or exporting
Product Use Restrictions: Not for direct human consumption, use under qualified supervision in food or lab settings only
