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Product Name: Prosultiamine
Chemical Name: O-hexylthiamine disulfide
Synonyms: Thiamine Propyldisulfide, Pro-sultiamine
Molecular Formula: C18H32N4O2S2
Molecular Weight: 396.6 g/mol
Recommended Use: Nutritional supplement, pharmaceutical intermediate
Supplier Details: [Manufacturer information supplied on product packaging]
Emergency Contact: [Refer to national poison center or local emergency numbers]
GHS Classification: Not classifiable as hazardous under GHS criteria
Health Hazards: May cause irritation to eyes, skin, and respiratory tract on prolonged or repeated exposure; ingestion unlikely to cause acute toxicity; pre-existing respiratory or skin conditions can be aggravated by large exposures
Environmental Hazards: Not considered a significant environmental hazard, though best handled carefully to prevent unnecessary release
Label Elements: Not subject to fatal hazard pictograms under GHS
Signal Word: None required
Precautionary Statements: Wash hands after handling, avoid inhalation or direct contact with skin and eyes, use suitable PPE in workplace settings
Main Component: Prosultiamine 98-100%
Impurities: Trace thiamine disulfide and excipient residuals (<2%)
Chemical Abstracts Service (CAS) No.: 820-79-9
Other Ingredients: None required or present in significant amounts based on industrial data
Inhalation: Move affected person to fresh air; provide oxygen if breathing slows or becomes labored; seek medical attention if symptoms persist
Skin Contact: Wash area thoroughly with plenty of soap and water; remove contaminated clothing; consult physician if irritation persists
Eye Contact: Rinse eyes gently under running water for at least 15 minutes; remove contact lenses if present and easy; follow up with medical attention if discomfort continues
Ingestion: Rinse mouth with water; do not induce vomiting without medical advice; seek immediate medical attention if significant exposure is suspected or individual feels unwell
Most Important Symptoms: Skin or eye irritation, mild headache, rarely gastrointestinal upset if large amounts are swallowed
Suitable Extinguishing Media: Water spray, dry chemical, foam, or carbon dioxide for larger fires; use media appropriate for surrounding materials
Unsuitable Extinguishing Media: High-pressure water jet may spread the powder or cause dust clouds
Specific Hazards: May emit oxides of sulfur, nitrogen, and carbon under combustion; avoid inhalation of smoke
Protective Equipment and Precautions: Firefighters should use self-contained breathing apparatus and full personal protective clothing to prevent contact with skin or respiratory tract
Special Firefighting Procedures: Isolate fire area, cool containers with water spray, prevent runoff into surface waterways or sewers
Personal Precautions: Evacuate unnecessary personnel; wear gloves, goggles, and dust mask to limit exposure; avoid creating airborne dust
Environmental Precautions: Prevent further leakage or spillage if safe to do so; avoid direct discharge to rivers, lakes, and soil
Containment Methods: Collect spilled material mechanically; use non-sparking tools to sweep or scoop up; transfer to a clean, labeled container for disposal
Clean-up Procedures: Ventilate area; wash surfaces with water and mild detergent to remove remaining residue
Handling: Avoid contact with eyes, skin, and clothing; prevent dust generation; use local exhaust in areas with possible dust formation; keep containers closed when not in use
Storage: Store in tightly sealed original packaging in a dry, cool, and well-ventilated place away from incompatible substances such as strong oxidizers; keep out of direct sunlight and moisture
Incompatible Materials: Strong acids, oxidizing agents
Specific Use(s): For laboratory, pharmaceutical, or nutraceutical applications as detailed by supplier
Keep Away From: Foodstuffs, animal feeds, and residential areas to avoid accidental cross-contamination
Exposure Limits: No occupational exposure limits established; handle as nuisance dust at levels below 10 mg/m3 for total dust
Engineering Controls: Provide adequate ventilation and local exhaust at points of dust formation; use dust collectors where necessary
Personal Protective Equipment: Safety glasses or chemical goggles, nitrile or latex gloves, and protective clothing recommended; in case of insufficient ventilation, use a dust mask or respirator meeting local standards
Hygiene Measures: Wash hands before breaks and after work; do not eat, drink, or smoke near product handling areas
Appearance: White to off-white crystalline powder
Odor: Mild, faintly sulfurous
Odor Threshold: Not established
Melting Point: 188-192°C
Boiling Point: Not applicable
Solubility: Slightly soluble in water, soluble in alcohol and chloroform
Vapor Pressure: Not volatile
pH: 4.5-7.0 (1% aqueous solution)
Relative Density: About 1.21 g/cm3
Partition Coefficient: Data not available
Flash Point: Not flammable below 200°C
Auto-ignition Temperature: Data not available
Decomposition Temperature: Over 190°C
Viscosity: Not relevant to typical handling
Chemical Stability: Stable at room temperature in closed containers under recommended storage conditions
Possible Hazards: Decomposes on prolonged exposure to intense heat, open flame, or strong oxidizing agents
Incompatible Materials: Strong acids and oxidizers, including peroxides and chlorates
Hazardous Polymerization: Will not occur under normal process conditions
Hazardous Decomposition Products: Releases sulfur and nitrogen oxides during burning or decomposition; can produce gaseous thiamine derivatives if overheated
Acute Toxicity: Oral LD50 (rat): >2000 mg/kg, considered low toxicity
Skin Corrosion/Irritation: May cause mild, reversible irritation upon prolonged contact
Eye Damage/Irritation: Mild irritation possible, usually reversible
Respiratory Effects: Large amounts of dust may cause discomfort or coughing
Chronic Effects: Long-term exposure data scarce; based on structural similarity to thiamine, unlikely to accumulate or cause organ toxicity
Carcinogenicity: Not listed by IARC, NTP or OSHA as a carcinogen
Reproductive Toxicity: No known reproductive or developmental toxicity established in animal studies
Sensitization: Not expected to sensitize skin or respiratory tract based on available studies
Ecotoxicity: Not classified as dangerous for the aquatic environment; low potential for bioaccumulation or long-term persistence
Mobility in Soil: Slight water solubility may promote leaching in high concentrations
Persistence and Degradability: Decomposes into thiamine and related substances in soil and water through microbial action
Bioaccumulation Potential: No significant bioaccumulation expected
Aquatic Toxicity: Minimal toxicity reported in aquatic species at high concentrations
Further Information: Release to environment should be limited in line with responsible laboratory and industrial practices
Disposal Methods: Dispose of in accordance with local, regional, and national environmental regulations; preferred method is incineration or disposal to approved chemical landfill, subject to authorities
Contaminated Packaging: Rinse containers, avoid reuse for food or drinking water, dispose as per chemical waste
Special Precautions: Avoid direct release to natural water bodies or municipal sewers
Waste Codes: Not classified as hazardous under most national waste control regulations, but local rules may vary
UN Number: Not regulated as a hazardous chemical for transport
Transport Hazard Class: Not applicable
Packing Group: Not applicable
Proper Shipping Name: Not classified as dangerous goods
Environmental Hazards: Not marine pollutant
Transport Precautions: Transport in dry, closed containers; prevent container breakage and excessive vibration; keep away from food and animal feed during transit
Regulatory Status: Prosultiamine not listed as a controlled or scheduled substance; not subject to special restrictions under common chemical inventories including TSCA and REACH
Labeling Requirements: Not required as hazardous in standard workplace or consumer labelling, though best practices suggest use of caution and appropriate hazard symbols
Product Registrations: Usage in food, feed, or pharmaceutical products depends on local legal registrations and approvals; consult regulatory listings in country of use
Other Regulations: Users should follow safety, health, and environmental guidelines from agencies such as OSHA, NIOSH, and local equivalents
Workplace Monitoring: Encourage use of workplace exposure monitoring where dust and handling volumes are significant
Specific Provisions: Additional documentation may be required for pharmaceuticals, dietary supplements, or clinical application in different countries
