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Product Name: Propranolol Hydrochloride
Chemical Formula: C16H21NO2·HCl
CAS Number: 318-98-9
Synonyms: Inderal Hydrochloride, Propranolol HCl
Manufacturer: Refer to specific supplier or manufacturer documentation
Recommended Use: Beta-blocker for cardiovascular treatments
Classification: Acute toxicity (oral, dermal, inhalation), Specific target organ toxicity, Eye irritation
Hazard Pictogram: Skull and crossbones, Exclamation mark
Signal Word: Danger
Hazard Statements: Harmful if swallowed; hazardous in contact with skin or if inhaled; may cause damage to organs; may cause eye irritation
Precautionary Statements: Avoid skin and eye contact; keep away from food and drink; do not eat, drink, or smoke while handling
Chemical Name: Propranolol Hydrochloride
Common Name: Propranolol HCl
Concentration: 100% (pure substance)
Impurities and Stabilizing Additives: No significant impurities reported for pharmaceutical-grade material
Molecular Weight: 295.8 g/mol
Inhalation: Move person to fresh air immediately; monitor for any breathing problems; seek medical attention if symptoms like dizziness, headache, or shortness of breath develop
Skin Contact: Remove contaminated clothing; wash skin thoroughly with soap and water; contact physician if irritation or symptoms develop
Eye Contact: Rinse immediately with water for several minutes; keep eyelids open; consult physician if eye irritation persists
Ingestion: Rinse mouth with water; do not induce vomiting; call poison center or doctor right away
Most Important Symptoms/Effects: Drowsiness, dizziness, low blood pressure, slowed heartbeat, possible respiratory problems
Suitable Extinguishing Media: Water spray, alcohol-resistant foam, dry chemical, carbon dioxide
Unsuitable Media: Do not use a direct water stream
Hazardous Combustion Products: Emits toxic fumes of nitrogen oxides, hydrogen chloride, carbon monoxide, and carbon dioxide when heated
Specific Hazards: Dust from powder may form explosive mixtures with air
Protective Equipment for Firefighters: Wear full protective clothing and self-contained breathing apparatus
Other Precautions: Keep containers cool with water spray and stay upwind of fire
Personal Precautions: Avoid contact with skin, eyes, and clothing; ensure adequate ventilation; use proper personal protective equipment (PPE)
Environmental Precautions: Prevent further leakage or spillage; do not allow product to enter drains or water courses
Methods for Cleaning Up: Carefully sweep or scoop up spilled material; place in a suitable, labeled disposal container; clean spill area thoroughly with detergent and water to remove trace residue
Specific Concerns: Use non-sparking tools and equipment to minimize dust generation
Handling: Wear protective gloves, clothing, and safety goggles; avoid inhalation of dust or vapor; keep container tightly closed; implement normal measures for preventive fire protection; wash hands thoroughly after handling
Storage: Store in a cool, dry, ventilated area away from incompatible substances such as strong acids, oxidizers, and bases; keep container tightly sealed; protect from light and moisture; avoid storage at elevated temperatures
Special Requirements: Secure area to prevent accidental exposure; ensure secure labeling of storage containers
Exposure Limits: No occupational exposure limits established for propranolol hydrochloride; minimize exposure to dust or particulates
Engineering Controls: Use local exhaust ventilation or other engineering controls to keep airborne levels below recommended exposure limits
Personal Protective Equipment (PPE): Chemical-resistant gloves, protective clothing, safety goggles, appropriate respiratory protection if ventilation is inadequate
Hygiene Measures: Wash thoroughly after handling; remove contaminated clothing and wash before reuse
Environmental Controls: Emission controls for air and water to prevent release into the environment
Appearance: White or off-white crystalline powder
Odor: Odorless
pH: Slightly acidic (pH 4-5, 1% solution in water)
Melting Point/Range: 163-167°C
Boiling Point/Range: Decomposes before boiling
Flash Point: Not applicable
Solubility: Freely soluble in water, chloroform, methanol, and ethanol; slightly soluble in acetone
Relative Density: Not available
Vapor Density: Not applicable
Volatility: Not volatile
Chemical Stability: Stable under recommended storage conditions
Reactivity: Non-reactive under normal handling circumstances
Hazardous Reactions: Contact with strong oxidizing agents, acids, or bases can cause hazardous decomposition
Hazardous Decomposition Products: Produces toxic gases such as nitrogen oxides, hydrogen chloride, and carbon monoxide during decomposition
Conditions to Avoid: Exposure to moisture, excessive heat, and incompatible substances
Acute Toxicity: LD50 (oral, rat): approximately 600 mg/kg; toxic by ingestion, skin absorption, or inhalation
Chronic Effects: Prolonged exposure can cause cardiovascular effects, CNS depression, respiratory problems
Irritation: May cause irritation to eyes, skin, and respiratory tract
Symptoms of Exposure: Headache, nausea, vomiting, bradycardia, hypotension, bronchospasm
Carcinogenicity: No data indicate carcinogenic potential in humans
Mutagenic Effects: Not regarded as mutagenic based on available studies
Reproductive Effects: Data insufficient for conclusive classification, consult specific study results
Aquatic Toxicity: Toxic to aquatic life, especially fish and microorganisms in waste treatment
Persistence and Degradability: Not readily biodegradable; can persist in the environment
Bioaccumulation Potential: Low potential based on chemical structure
Mobility in Soil: Product may leach into soil and contaminate groundwater if improperly disposed
Other Adverse Effects: Adverse impact on sewage treatment plants possible at high concentrations
Waste Treatment Methods: Dispose of contents in accordance with local, regional, and national regulations; do not release into the environment
Unused Product: Contact licensed waste disposal contractor for guidance
Contaminated Packaging: Triple rinse containers and dispose of using approved waste disposal methods
Precautions for Disposal: Avoid disposal through municipal sewers or landfill; incinerate under controlled conditions where permitted
UN Number: Not assigned for small quantities in research or pharmaceutical use
Proper Shipping Name: Propranolol Hydrochloride
Transport Hazard Class: Not classified as dangerous goods under most national/international transport regulations
Packing Group: Not applicable
Environmental Hazards: Not designated as environmentally hazardous for transport
Special Precautions: Protect packages from damage and keep securely closed during transport; handle with care to prevent spills
Safety, Health, Environmental Regulations: Handled as a prescription pharmaceutical under relevant pharmaceutical laws
Regulations / Codes: Not listed under US SARA Title III, CERCLA, or TSCA; subject to workplace safety regulations concerning chemical exposure and handling
Other Regulations: Not designated as a hazardous chemical by OSHA but should always be handled appropriately
Worker Protection: Mandatory training and health surveillance in facilities handling large volumes
Labeling Requirements: Follow current hazard communication standards; proper labeling for transport, storage, and waste
