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Product Name: Prilocaine Hydrochloride
Chemical Name: 2-(Propylamino)-o-propionotoluidide hydrochloride
CAS Number: 1786-81-8
Synonyms: N-(2-Methylphenyl)-2-(propylamino)propanamide hydrochloride
Molecular Formula: C13H21ClN2O
Molecular Weight: 256.77 g/mol
Recommended Use: Local anesthetic in medical and dental applications
Manufacturer/Supplier: [Manufacturer’s Name and Address]
Emergency Phone Number: [Local or International Emergency Number]
Classification: Acute toxicity (Oral, Dermal, Inhalation), Eye and skin irritant
Signal Word: Warning
Hazard Statements: Harmful if swallowed; causes skin and eye irritation; may cause allergic reactions to sensitive individuals
Pictograms: Exclamation mark, Health hazard
Precautionary Statements: Avoid breathing dust or vapors; wash hands thoroughly after use; wear protective gloves and safety goggles; do not eat, drink, or smoke when handling; in case of inadequate ventilation, wear respiratory protection
Substance: Prilocaine Hydrochloride
Concentration: 98–100%
Impurities: Methylaniline derivatives (typically trace amounts)
Additives: None reported for pure substance in sealed container
Other Identifiers: EC Number: 217-233-5
Inhalation: Move exposed person to fresh air, support breathing; seek medical attention if discomfort or symptoms persist
Skin Contact: Remove contaminated clothing, flush skin thoroughly with water and mild soap; consult healthcare if irritation develops
Eye Contact: Rinse with clean water for 15 minutes, keep eyelids open, seek immediate medical help if irritation remains
Ingestion: Rinse mouth with water, do not induce vomiting, obtain urgent medical assessment
Most Important Symptoms/Effects: Numbness of skin/mucosa, drowsiness, cyanosis, methemoglobinemia, possible respiratory depression
Note to Physician: Monitor for methemoglobinemia, give oxygen; methylene blue for severe cases
Suitable Extinguishing Media: Dry chemical, alcohol-resistant foam, carbon dioxide, water spray
Special Hazards: Emits toxic fumes under fire: nitrogen oxides, hydrochloric acid, carbon monoxide
Special Equipment for Firefighters: Self-contained breathing apparatus, flame-resistant protective clothing
Firefighting Procedures: Prevent runoff, use water mist to cool containers, evacuate area if high heat or heavy smoke present
Explosion Hazards: Non-flammable, but dust can form explosive mixtures with air if dispersed
Personal Precautions: Use proper personal protective equipment, ventilate area, avoid dust generation
Environmental Precautions: Prevent discharge to surface water, drain, soil; use barriers to contain spill
Spill Clean-Up Methods: Sweep up using non-sparking tools, transfer residues to appropriate labelled waste container, dispose as per regulations
Decontamination: Wash spill site with water after removal; ensure area is aired out before re-entry
Handling: Avoid inhalation, skin and eye contact; use in well-ventilated space; don’t eat, drink, or smoke while working; keep away from oxidizers
Storage Conditions: Store in original tightly closed container, dry cool environment below 25°C, away from direct sunlight or moisture
Incompatibilities: Strong oxidizing agents, strong acids, reducing agents
Specific Uses: Pharmaceutical anesthetic; restrict access to authorized personnel
Other Requirements: Maintain on-site access to emergency shower and eyewash
Occupational Exposure Limits: No official limit set; follow general chemical exposure guidance
Engineering Controls: Use local exhaust or general room ventilation to keep airborne concentrations low
Personal Protection: Protective latex/nitrile gloves, lab coat, face shield/chemical safety goggles; for dust, use NIOSH-approved respirator
Hygiene Measures: Wash thoroughly after handling; avoid touching face or exposed skin; remove contaminated clothing promptly
Environmental Exposure Controls: Prevent release to drains and water sources
Appearance: White crystalline powder
Odor: Odorless or faint chemical odor
pH (1% solution): 3.5–5.5
Melting Point: 168–172°C
Boiling Point: Decomposes
Flash Point: Not applicable
Solubility: Highly soluble in water, soluble in alcohol, practically insoluble in oils
Vapor Pressure: Not determined
Vapor Density: Not determined
Relative Density: Approx. 1.3 g/cm³
Partition Coefficient (log Kow): Approx. 2.1
Auto-ignition Temperature: Not applicable
Chemical Stability: Stable under recommended storage and handling
Reactivity: No hazardous polymerization; incompatible with oxidizing agents, acids
Hazardous Decomposition Products: Nitrogen oxides, carbon monoxide, hydrogen chloride under fire conditions
Conditions to Avoid: Excess heat, moisture, light
Other Reactivity Information: No dangerous reactions under normal use
Acute Toxicity: Oral LD50 (rat): approx. 600 mg/kg; Dermal LD50 (rabbit): approx. 2000 mg/kg
Chronic Toxicity: No IARC/OSHA/NTP classification as carcinogen
Skin/Eye Irritation: May cause irritation; repeated exposure increases risk
Inhalation: May cause respiratory tract irritation or central nervous system effects
Ingestion: Harmful if swallowed; can produce local anesthetic effects, CNS depression, methemoglobinemia
Sensitization: Reports of allergic contact dermatitis and immune reactions
Mutagenicity/Carcinogenicity: No conclusive evidence in animal systems
Teratogenicity/Reproductive Toxicity: Data insufficient; minimize maternal exposure during pregnancy/lactation
Eco-toxicity: Data limited for aquatic/soil toxicity; low bioaccumulation expected
Persistence/Degradability: Subject to microbial degradation; not persistent in environment under standard conditions
Mobility in Soil: Highly water soluble; moderate mobility expected
Bioaccumulative Potential: Low (log Kow below 2.5)
Other Adverse Effects: Avoid large scale release; can affect aquatic organisms if high concentration reaches surface waters
Precaution for E-Waste: Not specifically listed as a hazardous environmental pollutant
Waste Treatment: Dispose as hazardous pharmaceutical/chemical waste at licensed incineration or chemical disposal facility
Methods of Disposal: Do not dispose to municipal sewers, surface water, or soil
Container Disposal: Triple rinse and destroy empty containers, or return to supplier
Special Precautions: Ensure waste management practices prevent accidental exposure or environmental contamination
Regulatory Disposal Codes: Refer to local, regional, and national regulations (e.g., RCRA, CWA)
UN Number: Not assigned for non-bulk, non-restricted shipments
UN Proper Shipping Name: Prilocaine hydrochloride
Transport Hazard Class: Not classified as dangerous for transport
Packing Group: Not regulated under ADR/RID/IMDG/IATA
Transport Precautions: Ship in original labelled container, keep dry and protected from sunlight, handle with care
Special Transport Notes: Follow national/international regulations for pharmaceuticals as needed
U.S. TSCA: Listed
EU REACH Status: Registered/exempted for pharmaceutical use
OSHA Hazard Classification: Hazardous chemical as defined by 29 CFR 1910.1200
SARA Title III: Not specifically listed under Sections 302, 304, 313
International Inventories: Present on major inventories (EINECS, DSL, AICS, PICCS)
Other Labeling Laws: Subject to pharmaceutical handling and disposal restrictions
Workplace Control Standards: Employers must ensure training, labeling, and safety documentation availability
