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Product Name: Pregnenolone Acetate
Synonyms: 3β-Acetoxy-5-pregnen-20-one; Pregnenolone acetate
CAS Number: 1778-02-5
Recommended Use: Research and laboratory use, pharmaceutical intermediate
Supplier Details: Manufacturer and distributor information appear on packaging, with all contact information accessible for proper reporting and response
Emergency Contact: Emergency telephone numbers follow regulatory requirements and connect to qualified personnel
Product Form: Solid—typically crystalline powder
Classification: Not classified under GHS as hazardous, though exposure can cause health effects
Label Elements: No pictogram or signal word under GHS; precautionary measures explained verbally
Hazard Statements: Inhalation can cause respiratory discomfort or drowsiness; skin or eye contact may produce irritations such as redness, itching, or burning; ingestion or chronic exposure can depress steroid pathways and cause hormonal imbalances
Precautionary Statements: Use proper safety gear, avoid uncontrolled exposure, use engineering controls to avoid dust, minimize spillage, and always handle material in well-ventilated areas
Other Dangers: Not classed as combustible, but heated dust may cause dust explosions if dispersed in air and combines with heat and ignition sources
Chemical Identity: Pregnenolone Acetate
Molecular Formula: C23H32O3
Molecular Weight: 356.5 g/mol
Concentration: 98–100% (pure material)
Impurities: Typically low levels of related steroids or organic solvent residues from manufacturing, kept within established safety and quality standards
Identifiers: No mixture—single active compound for the grade typically sold
Eye Contact: Rinse eyes immediately with plenty of water—hold eyelids apart and wash for at least 15 minutes; consult physician if irritation persists
Skin Contact: Remove contaminated clothing, rinse exposed area with soap and water, monitor for persistent redness or swelling; seek medical care if symptoms develop
Inhalation: Move victim to fresh air, monitor for cough, wheezing, or shortness of breath; seek care if any symptoms persist or worsen
Ingestion: Rinse mouth thoroughly with water, do not induce vomiting; drink water for dilution and seek medical attention for any discomfort or sustained symptoms
Most Important Symptoms: Cough, respiratory tract irritation, skin rash, hormonal symptoms with chronic or significant overdose such as fatigue, mood changes, or menstrual disturbances
Suitable Extinguishing Media: Dry powder, carbon dioxide, or foam
Unsuitable Extinguishing Media: Direct water spray on burning powder can create dust clouds or spread flames
Specific Hazards: Combustion can release toxic fumes such as carbon monoxide, carbon dioxide, and possible steroid decomposition products
Protective Equipment: Firefighters use self-contained breathing apparatus and full protective gear to avoid inhaling combustion products
Special Procedures: Cool exposed closed containers with water spray to prevent rupture from heat; avoid stirring up dust near flames or hot surfaces
Additional Considerations: Move material away from the fire area if judged safe; prevent water used in firefighting from entering drains or waterways
Personal Protection: Wear chemical-resistant gloves, safety goggles, lab coat; ensure adequate ventilation and avoid inhaling dust
Spill Response: Scoop or brush material into sealed, properly labeled container; minimize dust creation using damp cloth or non-sparking tools
Environmental Precautions: Avoid discharge into drains, soil, or waterways; report significant spills to authorities as required by local regulations
Cleanup Methods: After collecting solid material, wipe surfaces with wet cloth and dispose of waste in accordance with regulatory disposal procedures; decontaminate tools and affected workspace
Handling Procedures: Avoid contact with eyes, skin, and clothing; do not eat, drink, or smoke while handling; use only in ventilated areas or fume hood
Technical Measures: Use glove boxes or containment devices for weighing and transferring the material; wear respirators where dust can form
Storage Conditions: Store in tightly sealed container, cool, dry location, shielded from light and incompatible substances; maintain clear labeling
Incompatibilities: Keep away from strong oxidizers, acids, or alkalies; prevent contact with heat, flame, or sources of ignition
Repackaging Guidance: Keep transfer and weighing areas clean to prevent cross-contamination or dust accumulation; prevent storage near food, feedstuffs, or public access areas
Exposure Limits: No official occupational exposure limit value for Pregnenolone Acetate exists, though precautions mirror those for similar steroid hormones
Engineering Controls: Work only in fume hood, glove box, or with local exhaust to minimize airborne concentrations
Personal Protection: Wear chemical splash goggles, NIOSH-approved respirator for solid particulates, lab coat, nitrile or neoprene gloves
Hygiene Measures: Wash hands thoroughly after use; change contaminated clothing before leaving handling area
Environmental Controls: Prevent dust or aerosol migration with fitted ventilation and particulate capturing filters; avoid waste discharge into general environment
Appearance: White to off-white crystalline powder
Odor: Typically odorless
Odor Threshold: Not determined
pH: Not applicable (insoluble in water)
Melting Point: Range between 145–150 °C
Boiling Point: Decomposes before boiling
Solubility: Soluble in organic solvents (ethanol, chloroform, acetone); insoluble in water
Vapor Pressure: Negligible at room temperature
Partition Coefficient (log Kow): Estimated at 3.45
Flash Point: Non-volatile, not easy to ignite under standard laboratory conditions
Evaporation Rate: Not applicable
Bulk Density: Varies with manufacturer, typical range 0.4–0.6 g/cm³
Other Properties: Stable under recommended storage and handling; dust can irritate respiratory tract if airborne
Chemical Stability: Remains stable at ambient temperature and pressure if kept dry and out of sunlight
Conditions to Avoid: High humidity, direct sunlight, excessive heat; avoid mechanical shock or crush situations that can aerosolize dust
Incompatible Materials: Strong oxidizing agents, acids, bases, halogenated hydrocarbons
Hazardous Decomposition Products: Incomplete combustion may release carbon monoxide, carbon dioxide, and toxic organic fragments
Polymerization: Does not polymerize under normal conditions
Reactivity: Low reactivity unless exposed to high energy, oxidants, or strong acids/bases
Acute Toxicity: Not acutely toxic by oral or dermal exposure at typical laboratory amounts
Inhalation: Dust irritation of nasal membranes or lungs, possible cough, soreness, or headache
Dermal Contact: Transient irritation, dryness, or redness possible for sensitive skin
Eye Contact: Mild irritation, tearing, or burning sensation if direct contact occurs
Ingestion: Large doses cause nausea, vomiting, abdominal pain, and possible systemic hormonal disturbances
Chronic Effects: Disruption of steroid pathways—fatigue, mood swings, reproductive disturbances, and skin changes with repeated uncontrolled exposure
Carcinogenicity, Mutagenicity, Reproductive Toxicity: Not classified as carcinogenic or mutagenic, but potential hormonal effects suggest avoiding prolonged uncontrolled use
Environmental Fate: Degrades slowly in soil and water, persistent if released in large quantities
Aquatic Toxicity: Effects on fish, invertebrates, or algae not fully studied, but hormones in waterways disrupt reproduction in some aquatic species
Soil Interaction: Low mobility, binds to soil particles; slow microbial degradation
Bioaccumulation: Not expected to bioaccumulate significantly, but risk remains if persistent inputs occur
Other Ecological Effects: Avoid deliberate or accidental release; any spill into drains, waterways, or natural habitats should be remediated quickly
Waste Handling: Dispose as hazardous chemical waste, regardless of amount or perceived hazard
Container Disposal: Triple rinse packaging, deface labeling, and deliver both solid waste and empty containers to approved hazardous waste treatment site
Physical and Chemical Disposal Methods: Incinerate in licensed facility intended for pharmaceutical or chemical waste disposal
Prohibited Disposal: Never flush into drains, waterways, or municipal trash
Regulatory Note: Follow local, state, and national regulations for chemical waste handling to avoid legal or ecological repercussions
UN Number: No UN shipping number assigned for Pregnenolone Acetate
Proper Shipping Name: Not classified as dangerous for transportation by air, land, or sea
Hazard Class: Not regulated as hazardous material
Packing Group: Not required
Transport Labeling: Include clear identification and hazard precautions as internal policy, even when not required by code
Additional Information: Shipment within the laboratory or between facilities requires spill-proof packaging, secondary containment, and full documentation
Emergency Response: Ship with emergency contact numbers and response instructions
Occupational Safety: Material falls under workplace safety laws for chemical substances; employers enforce safety training and proper handling
OSHA Status: No specific ceiling value or PEL; general duty clause applies
REACH, TSCA, and Related Directives: Product may not be listed under general chemical inventories due to its use as a research intermediate
Labeling Requirements: Follow jurisdictional requirements: chemical identification, hazard statements, precautionary measures, supplier and emergency contact
Other Regulatory Notes: Countries or states can have their own requirements for handling, labeling, transport, and disposal—those rules take precedence
