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Product Name: Prednisone Acetate
Chemical Name: 17,21-dihydroxypregna-1,4-diene-3,11,20-trione 21-acetate
Synonyms: Prednisone 21-Acetate, Deltasone Acetate
CAS Number: 125-10-0
Recommended Use: Pharmaceutical synthesis, research
Manufacturer: Pharmaceutical producers or chemical suppliers
Contact Details: Refer to supplier documentation for phone numbers and emergency helplines
Emergency Number: Listed with safety contacts or poison control
Address: Found on the container or supplier’s packaging
Classification: Not classified as highly hazardous according to GHS guidelines
Potential Health Effects: Can cause irritation to eyes, skin, respiratory tract; known to cause immunosuppression, endocrine disruption, and possible adverse reproductive effects in humans through repeated exposure; ingestion can result in headaches, nausea, mood changes, and elevated blood glucose
Label Elements: May display exclamation mark pictogram for irritant category; warning statements about accidental ingestion or inhalation
Environmental Hazards: Expected to have low acute toxicity to aquatic environments, but persistent chemicals may cause long-term effects
Signal Word: Warning
Main Ingredient: Prednisone Acetate
Chemical Formula: C23H28O6
Concentration: Typically supplied at near-pure or pharmaceutical grade (≥98%)
Other Ingredients: Inactive formula may contain excipients for pharmaceutical preparations; technical grade may have traces of related steroids or carrier substances
Impurities: Minimal amounts of by-products remain from synthesis in pure pharmaceutical forms; check lot-specific certificate of analysis
Inhalation: Move affected person to fresh air; seek medical attention for respiratory symptoms such as shortness of breath or irritation
Skin Contact: Remove soiled clothing; wash with plenty of soap and water; if redness or irritation develops, contact a healthcare professional
Eye Contact: Rinse with gentle stream of water for at least 15 minutes, keeping eyelids open; obtain medical advice if discomfort continues
Ingestion: Rinse mouth; give water to dilute if person is fully alert; do not induce vomiting; seek immediate medical care
Most Important Symptoms: Gastrointestinal distress, hormonal changes, allergic reaction, possible immunosuppression
Suitable Extinguishing Media: Water spray, foam, dry powder, carbon dioxide
Unsuitable Extinguishing Media: Direct high-pressure water may spread powdered material
Hazards from Combustion: May emit toxic fumes of carbon monoxide, carbon dioxide, and unknown organic compounds if combusted
Protective Equipment: Firefighters require self-contained breathing apparatus and full protective clothing
Precautions: Avoid inhaling smoke or fumes; contain contaminated water to keep it from entering drains
Personal Precautions: Wear gloves, safety goggles, dust mask or respirator if dust is present
Environmental Precautions: Prevent from entering waterways, drains, or soil
Containment: Sweep or vacuum spilled powder gently using tools that reduce dust generation; place waste in leak-proof containers
Clean-up Methods: Wipe with damp cloth after collection of bulk material; dispose of contaminated cleaning materials as pharmaceutical waste
Safe Handling Guidance: Avoid contact with skin, eyes, and clothing; practice good personal hygiene; use in well-ventilated area or under fume hood
Storage Conditions: Store in tightly closed containers, kept in a cool, dry, and well-ventilated place away from direct light
Incompatibilities: Shield from strong acids, alkalis, and oxidizing agents
Special Measures: Limit access to trained personnel
Hygiene Requirements: Wash hands after handling, before eating, drinking, or smoking; keep away from food and beverages
Exposure Limits: No established occupational exposure limits for prednisone acetate, but minimize exposure as with all potent pharmaceutical materials
Engineering Controls: Use fume hood, local exhaust, or adequate general ventilation
Personal Protection: Wear chemical-resistant gloves (nitrile, neoprene), safety goggles, and laboratory coat
Respiratory Protection: Dust mask or respirator recommended if airborne concentrations can occur
Environmental Controls: Prevent spills from entering environment; use containment for liquid forms
Other Protection: Eye wash and shower stations close to work area
Appearance: White to off-white crystalline powder
Odor: Odorless or faint characteristic chemical aroma
Odor Threshold: Not applicable
pH: Not determined
Melting Point: 240–250°C (464–482°F)
Boiling Point: Decomposes before boiling
Solubility: Slightly soluble in water; readily soluble in ethanol, methanol, acetone, chloroform
Partition Coefficient (Log Pow): Around 1.6
Vapor Pressure: Not measurable at room temperature
Density: 1.33 g/cm³
Stability in Light: Slowly decomposes if exposed to light
Formulation pH (if applicable): Check manufacturer’s data for preparations
Chemical Stability: Stable under recommended storage conditions—protected from light, moisture, and air
Reactivity: Inert under normal laboratory or storage conditions
Decomposition Products: CO, CO2, acetic acid, unidentified organic vapors
Conditions to Avoid: Exposure to sunlight, high temperature, or moisture can degrade the product
Incompatible Materials: Strong acids, alkalis, and oxidizers may react and destroy activity
Hazardous Polymerization: Will not occur
Likely Routes of Exposure: Inhalation, dermal contact, accidental ingestion
Acute Health Effects: Limited human toxicity data, but can cause eye, skin, and respiratory tract irritation; systemic absorption has marked pharmacological actions
Chronic Health Effects: Long-term exposure may disrupt endocrine and immune function, cause changes in mood, induce hyperglycemia, Cushingoid features, and metabolic disturbances
Carcinogenicity: Not listed as carcinogenic by NTP, IARC, or OSHA
Mutagenicity: No strong evidence in animal or in vitro studies
Developmental Effects: Possible risk to fetus based on glucocorticoid pharmacology; avoid during pregnancy unless medically justified
Acute Toxicity Data: LD50 (oral, rat): >3,000 mg/kg (low acute toxicity)
Aquatic Toxicity: No detailed studies, but as a steroid, may impact aquatic organisms at low concentrations over long exposure
Persistence and Degradability: Slowly biodegradable in environment; risk of persistence in soil and water
Bioaccumulative Potential: Not expected to bioaccumulate to significant levels
Mobility: Low mobility in soil; partitions into organic matter
Other Ecological Concerns: May disturb endocrine function in wildlife; avoid direct release into waterways or sewage systems
Waste Treatment: Dispose through chemical or pharmaceutical waste management services
Incineration: Preferred method for destruction; complete combustion recommended
Landfill: Only as last resort and in accordance with local regulations
Packaging Disposal: Dispose of containers as hazardous waste; do not reuse contaminated packaging
Precautions: Minimize bulk disposal to environment
UN Number: Not regulated for transport as a dangerous good
Transport Hazard Class: Not applicable
Packing Group: Not applicable
Marine Pollutant: Not considered a marine pollutant
Transport Labels: None required for ordinary transport; keep container tightly closed during movement
Special Transport Measures: Protect from rough handling, major temperature shifts, or accidental release in transit
US Regulations: Not listed as hazardous chemical; consult FDA and DEA controls if handling large quantities as a scheduled pharmaceutical
EU Regulations: Not classified as a dangerous substance under CLP; regulated for pharmaceutical production and trade
Other Regions: Compliance required with specific import/export and labeling requirements
Worker Protection: OSHA laboratory standard applies for workplace safety
SARA Title III: Not listed as reportable hazardous substance
WHMIS Classification: Not controlled product in Canada
Other Requirements: Follow national and local guidelines for chemical handling, storage, and disposal
