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Product Name: Prednisolone Sodium Phosphate
Synonyms: Disodium 21-Phospho-Prednisolone, Prednisolone 21-Phosphate Disodium Salt
Chemical Formula: C21H27Na2O8P
CAS Number: 125-02-0
Intended Use: Pharmaceutical ingredient for anti-inflammatory and immunosuppressive applications
Manufacturer: Refer directly to packaging or procurement information for exact source details
Contact Information: Refer to product label or supplier documentation for emergency numbers and support resources
Emergency Contact: Provided on official labeling for authorized distributors and transporters
GHS Classification: Not classed as hazardous under GHS; product can irritate eyes, skin, and respiratory tract
Signal Word: Warning
Hazard Statements: May cause eye and skin irritation; potential to aggravate pre-existing respiratory, immune, or endocrine disorders on prolonged exposure
Pictograms: Exclamation mark (for irritation)
Precautionary Statements: Avoid direct inhalation, ingestion, or contact with skin and eyes; seek medical advice if symptoms develop
Potential Effects of Overexposure: Headache, dizziness, allergic reactions, hormonal disturbances in vulnerable populations
Other Hazards: Environmental release may affect aquatic life at significant concentrations
Chemical Name: Prednisolone Sodium Phosphate
PURITY: >98% typical for pharmaceutical applications
Ingredient: Prednisolone Sodium Phosphate
Concentration: Active pharmaceutical ingredient, presence as main constituent
Impurities: No known hazardous impurities at levels typically present
Excipients: None unless formulated, check finished product labeling for further components
Inhalation: Move to fresh air; seek medical attention if breathing becomes difficult
Skin Contact: Wash with soap and water; remove contaminated clothing; medical advice recommended if irritation persists
Eye Contact: Flush cautiously with water for 15 minutes; obtain medical attention if discomfort continues
Ingestion: Rinse mouth with water; seek immediate medical attention and show container or label
Other Important Actions: Provide symptomatic treatment; observe for signs of hormonal effect in repeated exposure scenarios
Suitable Extinguishing Media: Use water spray, dry chemical, CO2, or foam as suitable for local fire environment
Specific Hazards: Product decomposes in fire to release oxides of phosphorus and sodium; toxic fumes possible
Protective Equipment for Firefighters: Wear self-contained breathing apparatus and full protective gear
Special Precautions: Avoid inhaling combustion gases; keep containers cool by spraying water if involved in fire
Fire Risk Factors: Fine dust may form explosive mixtures with air though not common in normal handling
Personal Precautions: Wear gloves, goggles, and mask to minimize exposure risk
Spill Containment: Use damp cloth or absorbent material for dry spills; prevent runoff into drains or waterways
Cleanup Procedures: Collect product carefully, place in sealed container for disposal, ventilate area
Environmental Precautions: Avoid release into environment; notify authorities if significant quantities enter waterways or public sewer
Disposal of Contaminated Material: Refer to local regulations for chemical waste disposal
Handling Precautions: Store in tightly sealed containers; avoid creating dust or aerosol
Personal Hygiene: Wash hands thoroughly after handling; avoid eating, drinking or smoking during use
Safe Storage Conditions: Keep in cool, dry, well-ventilated space away from incompatible materials such as strong oxidizers
Container Requirements: Use chemical-resistant, clearly labeled packaging
Engineering Controls: Use with local exhaust ventilation if dust generation is likely
Occupational Exposure Limits: No established workplace limits, minimize exposure according to good practice
Respiratory Protection: Use appropriate mask or respirator in situations where dust or aerosol can form
Skin Protection: Use chemical-resistant gloves; long-sleeved lab coats or gowns
Eye Protection: Safety goggles in any setting with risk of splashing or dusting
Engineering Measures: Local exhaust ventilation and containment recommended for bulk handling
Other Protective Equipment: Emergency eyewash station and washing facilities nearby
Appearance: White to off-white crystalline powder
Odor: Odorless
Solubility: Freely soluble in water, limited solubility in organic solvents
pH (1% solution): 7.5–9.5
Melting Point: 242°C (decomposition)
Boiling Point: Not applicable (decomposes before boiling)
Vapor Pressure: Not applicable, solid pharmaceutical
Partition Coefficient: Not available
Flash Point: Not flammable
Auto-ignition Temperature: Not determined
Explosive Properties: No significant risk under normal conditions
Oxidizing Properties: No
Chemical Stability: Stable under recommended storage and handling
Conditions to Avoid: Prolonged exposure to moisture or heat, contact with strong oxidizing agents
Incompatible Materials: Strong oxidizers, acids
Hazardous Decomposition: Phosphorus oxides, sodium oxides, carbon oxides
Hazardous Polymerization: Not known to occur
Acute Toxicity: Oral LD50 in rodents >1000 mg/kg; low order of acute toxicity in mammals, but use only as directed
Routes of Exposure: Inhalation, skin contact, eye contact, ingestion
Primary Effects: Eye and skin irritation, potential for long-term endocrine effects with repeated or high-dose exposure
Sensitization: No sensitization observed in animal studies
Chronic Exposure: Risk of immunosuppression, adrenal suppression and shifts in metabolism
Carcinogenicity: Not classed as carcinogen by IARC, NTP, OSHA
Mutagenicity: No evidence in available data
Reproductive Effects: Possible impacts with high or repeated doses, based on corticosteroid class
Ecotoxicity: Product may be harmful to aquatic organisms at high concentrations
Mobility: Soluble in water; may move through soil and water systems
Persistence and Degradability: Biodegradation pathways not fully characterized; likely moderate persistence
Bioaccumulation: Low potential based on water solubility
Other Adverse Effects: No large-scale environmental harm at pharmaceutical-level exposures, but prevent uncontrolled discharge
Waste Disposal Method: Send to approved chemical or pharmaceutical waste handling facility
Special Instructions: Do not flush to sewer or allow significant release to surface waters
Packaging Disposal: Rinse and dispose of containers as hazardous waste in compliance with local rules
Contaminated Waste: Collect via sealed, labeled containers to prevent dust and residue escape
Regulatory Requirements: Follow local, state, federal guidelines for pharmaceutical disposal
UN Number: Not regulated for ground, air, or sea transport
Transport Hazard Class: Not classified
Packing Group: Not applicable
Labeling Requirements: Chemical name and hazard identification as per regulations
Special Transport Precautions: Avoid extreme temperatures; secure containers to prevent spillage
Environmental Hazards: Not considered a marine pollutant at normal transport volumes
OSHA Status: Not listed as hazardous under US OSHA standards
TSCA Status: Listed or exempt
EU Classification: Not classified as hazardous according to CLP Regulation (EC 1272/2008)
WHMIS Classification (Canada): Not controlled
Other National Regulations: Handled as prescription pharmaceutical; local laws may require tracking, secure storage, and disposal
Other Regulations: Transport, use, and disposal governed by international pharmaceutical and health safety standards; observe specific requirements in recipient jurisdictions
