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Product Name: Praziquantel
Chemical Name: 2-(Cyclohexylcarbonyl)-1,2,3,6,7,11b-hexahydro-4H-pyrazino(2,1-a)isoquinolin-4-one
Synonyms: Biltricide, Cesol, Droncit, Prazitel
CAS Number: 55268-74-1
Recommended Uses: Anthelmintic for parasite control in humans and animals
Supplier: Details supplied by manufacturer/distributor
Emergency Phone: Refer to local supplier’s information
Classification: Not considered hazardous under normal laboratory or handling conditions
Hazard Statements: Can cause irritation if inhaled, ingested, or in contact with eyes and skin
Label Elements: None assigned for bulk pharmaceutical ingredient; prudent safety practices advised
Symptoms of Overexposure: Gastrointestinal discomfort, headache, dizziness, allergic reactions possible in sensitive individuals
Precautionary Statements: Avoid direct contact, minimize dust generation, wash hands thoroughly after handling
Chemical Identity: Praziquantel
Concentration: 100% pure or as specified by supplier
Impurities/Additives: No concern at levels normally found; batch-specific data available on request
Molecular Formula: C19H24N2O2
Molecular Weight: 312.41 g/mol
General Advice: Remove contaminated clothing; seek medical attention if symptoms persist
Inhalation: Move to fresh air, keep airways open; oxygen or artificial respiration if necessary
Skin Contact: Wash with plenty of soap and water; get medical attention in case of irritation
Eye Contact: Rinse under running water for at least 15 minutes; seek immediate medical care
Ingestion: Rinse mouth, drink water, do not induce vomiting unless advised by medical personnel
Most Important Symptoms: Rash, stomach upset, rare potential for allergic responses
Notes for Physicians: Treat symptoms; no specific antidote documented
Suitable Extinguishing Media: Water spray, dry chemical powder, foam, or carbon dioxide
Unsuitable Media: Full water jet may spread material
Specific Hazards: Emits toxic fumes (oxides of carbon, nitrogen) on combustion
Protective Equipment for Firefighters: Self-contained breathing apparatus, full protective gear
Other Information: Product will not easily ignite but may contribute to fire if substantial quantities present
Personal Protection: Wear gloves, goggles, dust respirator; avoid breathing dust
Environmental Precautions: Keep product out of drains, waterways, and soil
Methods for Clean-Up: Sweep up spillage, transfer to suitable containers; ventilate area
Decontamination: Wash spill site with water and detergent after material pick-up
Disposal Considerations: Follow local and national regulations for pharmaceutical waste
Handling Procedures: Use good industrial hygiene practices, minimize dust, avoid direct contact
Technical Measures: Work in well-ventilated space, preferably in fume hood
Hygiene Measures: No smoking, eating, or drinking in work areas; wash thoroughly after handling
Storage Conditions: Store in tightly closed original container in cool, dry, well-ventilated place
Incompatible Materials: Strong acids, strong bases, oxidizers
Storage Class: Pharmaceutical/chemical storage
Occupational Exposure Limits: No threshold limit value (TLV) specifically established for praziquantel
Engineering Controls: Local exhaust ventilation or containment system
Personal Protective Equipment: Chemical-resistant gloves, lab coat, safety glasses with side-shields
Respiratory Protection: Dust respirator or mask if exposure limits likely exceeded
Environmental Exposure Controls: Prevent discharge to environment or open waterways; procedures for waste management in place
Physical State: Solid (crystalline powder)
Color: White to off-white
Odor: Odorless
pH: Essentially neutral in water
Melting Point: Approximately 136 – 138°C
Boiling Point: Data not available
Flash Point: Not readily flammable
Solubility: Slightly soluble in water, freely soluble in ethanol, soluble in chloroform and DMSO
Partition Coefficient (log Pow): 2.3 – 2.5
Vapor Density: Not applicable
Other Properties: Stable at normal atmospheric temperatures and pressures
Reactivity: Product remains stable under recommended storage and handling conditions
Chemical Stability: Stable at room temperature, sensitive to moisture and light
Hazardous Reactions: Avoid strong oxidizing agents, acids, and bases
Decomposition Products: Toxic fumes of carbon monoxide, carbon dioxide, nitrogen oxides when heated
Conditions to Avoid: Excessive heat, moisture, direct sunlight, incompatible substances
Routes of Exposure: Oral, inhalation, skin, and eye contact
Acute Toxicity: LD50 (oral, rat): > 2,800 mg/kg
Chronic Effects: Data on chronic exposure limited; long-term effects not observed in therapeutic use
Skin Irritation: Generally not a skin irritant; possible hypersensitivity in some individuals
Eye Irritation: Dust may cause mild mechanical irritation
Sensitization: Reports of allergy rare; consider risk for sensitized individuals
Carcinogenicity/Mutagenicity: Not classified as carcinogen, mutagen, or reproductive toxicant
Other Health Effects: Drowsiness, headache, rare hepatic or renal disturbance at high exposures
Environmental Mobility: Poor water solubility limits mobility in soil and waterways
Aquatic Toxicity: Limited data; not expected to pose acute risk at predicted environmental concentrations
Persistence and Degradability: Expected to degrade slowly in environment; not readily biodegradable
Bioaccumulation Potential: Moderate, low log Kow; unlikely to biomagnify significantly
Other Effects: Avoid uncontrolled release; pharmaceutical active ingredients should not enter watercourse
General Waste Procedure: Collect product and contaminated packaging as pharmaceutical waste
Disposal Methods: Incineration preferred for bulk quantities; follow local regulations
Container Handling: Empty packaging must be handled as hazardous; do not reuse
Special Precautions: Do not allow product to reach sewage systems, surface water, or groundwater
Regulatory Requirements: Dispose in accordance with regional, national, and local laws
UN Number: Not regulated as a hazardous material for transport
Proper Shipping Name: Praziquantel
Transport Hazard Classes: No classification required under ADR/RID/IMDG/IATA
Packing Group: Not assigned
Special Transport Precautions: Secure packaging to prevent breakage; keep container closed and dry
Safety, Health, and Environmental Regulations: Praziquantel does not have strict hazard classification under GHS or regionally specific law
Inventory Status: Listed on relevant chemical inventories in EU, USA, Canada, Australia, Japan
OSHA Standards: Not specifically regulated by OSHA
EPA Status: Not classified under RCRA or as a hazardous air pollutant
Other Requirements: Product regulated as medicament in many regions; respect applicable handling, storage, and disposal legislation
