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Product Name: Polyinosinic-Polycytidylic Acid
Synonyms: Poly I:C
Chemical Family: Synthetic double-stranded RNA
CAS Number: 31852-29-6
Recommended Use: Research, vaccine adjuvant, immune response modulation
Supplier Contact: Refer to the manufacturer for supplier address and emergency telephone
Hazard Classification: Not listed as a hazardous chemical by GHS or OSHA, but may cause irritation and immune response if inhaled or in contact with skin or eyes
Label Elements: No pictogram required
Signal Word: None
Hazard Statements: May cause respiratory tract, eye, and skin irritation. Immune system stimulation possible
Precautionary Statements: Avoid contact, use personal protective equipment, handle in a biosafety cabinet
Other Hazards: Not known to be carcinogenic or mutagenic; may aggravate conditions involving hypersensitive immune systems
Chemical Name: Polyinosinic-polycytidylic acid
Common Name: Poly I:C
CAS Number: 31852-29-6
Concentration: Usually supplied as lyophilized powder, pure or dissolved in saline/buffer
Impurities/Stabilizers: None relevant for standard laboratory use
Inhalation: Move person into fresh air; seek medical attention if irritation or respiratory difficulty continues
Skin Contact: Wash affected area well with water and soap; take off contaminated clothing
Eye Contact: Rinse eyes with water for several minutes; remove contact lenses if present; medical attention if symptoms persist
Ingestion: Rinse mouth, do not induce vomiting, seek medical advice with material data
Most Important Symptoms: Breathing difficulty, skin redness, immune reaction in rare cases
Suitable Extinguishing Media: Water spray, carbon dioxide, dry powder, foam
Unsuitable Extinguishing Media: None identified based on available data
Fire/Explosion Hazards: Decomposition products may include nitrogen and carbon oxides under fire conditions
Protective Equipment: Wear self-contained breathing apparatus and protective wear for fire scenes
Special Procedures: Avoid inhaling fumes; keep containers cool with water spray
Personal Precautions: Ensure ventilation, avoid breathing dust or vapor, wear PPE including gloves and goggles
Environmental Precautions: Prevent runoff into drains, sewers, or waterways
Methods for Clean-Up: Use absorbent material, collect residue for disposal in chemical waste, decontaminate area with suitable disinfectant
Emergency Procedures: Evacuate area if risk of inhalation exists, restrict access until cleaned
Safe Handling: Minimize dust generation, avoid skin and eye contact, do not eat or drink near use area, use BIOSAFETY CABINET if aerosol risk
Storage Conditions: Store sealed in a cool, dry, well-ventilated place, protect from light and moisture, recommended to freeze at -20°C for long-term stability
Incompatible Materials: Strong oxidizing agents
Hygiene Practices: Wash hands thoroughly after handling, clean spills promptly
Exposure Limits: No established occupational exposure limits
Engineering Controls: Work in well-ventilated area, fume hood or biosafety cabinet recommended
Personal Protective Equipment: Lab coat, gloves (nitrile preferred), chemical splash goggles
Respiratory Protection: Use of mask or respirator if dust or aerosolization possible
Environmental Controls: Ensure procedures minimize emissions to environment, use closed systems or exhausts
Appearance: White to off-white lyophilized powder or clear solution
Odor: Odorless
pH: Neutral in solution (6.5–7.5)
Melting Point/Freezing Point: Not determined
Boiling Point: Not applicable
Solubility: Soluble in aqueous buffers
Vapor Pressure: Not applicable
Relative Density: Not determined
Partition Coefficient: Not available
Decomposition Temperature: Not determined, decomposes under fire
Viscosity: Not relevant
Chemical Stability: Stable at recommended storage conditions
Possible Hazardous Reactions: No known hazardous reactions under normal use
Conditions to Avoid: Excess moisture, light, heat above ambient, exposure to bases/oxidizers
Incompatible Materials: Strong oxidizing and reducing agents, acids and bases
Hazardous Decomposition: Nitrogen oxides, carbon monoxide/dioxide can release in fire
Acute Toxicity: Not acutely toxic in standard lab practice, but immune stimulatory capacity may cause responses in hypersensitive individuals
Routes of Exposure: Inhalation, ingestion, dermal, eye
Symptoms: Skin/eye redness, irritation, respiratory tract discomfort, immune activation
Chronic Toxicity: No reliable data suggesting carcinogenic, mutagenic, reproductive, or developmental effects. May enhance immune hypersensitivity on repeated exposure
Target Organs: Immune system, lungs, skin, eyes
Delayed Effects: Possible flu-like symptoms if significant exposure
Ecotoxicity: Limited data, likely low environmental toxicity, can degrade in natural conditions
Persistence and Degradability: Degrades by nucleases in environment, does not persist
Bioaccumulation: Low potential for bioaccumulation
Mobility in Soil: Readily mobile in water but rapidly degraded
Other Adverse Effects: Not likely to cause harmful effects at environmental concentrations from research settings
Waste Treatment Methods: Dispose of unused material, solutions, and contaminated supplies by incineration or as hazardous biomedical waste following institutional, state, and federal guidelines
Packaging: Triple containment for contaminated material
Reuse/Recycling: Do not reuse or recycle material from laboratory use
Special Instructions: Autoclave prior to disposal if risk of biohazard tags present
UN Number: Not classified as dangerous for transport
UN Proper Shipping Name: Not regulated
Transport Hazard Class: None
Packing Group: None
Marine Pollutant: No
Special Precautions: Avoid temperature extremes; ship with cold packs if long transit
Federal Regulations: Not listed by TSCA, SARA, CERCLA, or RCRA as hazardous
State Regulations: Poly I:C is not specifically listed under California Proposition 65 or equivalent statutes
International Regulations: Not classified as dangerous under EU CLP or REACH; use classified for laboratory/research
Other Information: Observe all national/local regulations for safe use and disposal
