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Product Name: Poloxamer P407/F127
Chemical Family: Polyoxyethylene-polyoxypropylene block copolymer
CAS Number: 9003-11-6
Synonyms: Pluronic F127
Recommended Uses: Common in pharmaceuticals, cosmetics, drug delivery, lab reagents
Manufacturer/Distributor: Provide name, address, emergency phone number as per local requirements
GHS Classification: Not classified as hazardous
Main Hazards: May cause mild eye or skin irritation in some people
Signal Word: None required
Hazard Statements: Not regarded as hazardous under normal lab conditions
Precautionary Statements: Avoid contact with eyes, skin; practice good hygiene
Hazards Not Otherwise Classified: Not flammable, not explosive, not reactive under typical use
Chemical Name: Poly(oxyethylene)-poly(oxypropylene) block copolymer
Formula: (C2H4O)n-(C3H6O)m-(C2H4O)n
Concentration: >99% (pure form)
Impurities: Trace impurities, no significant toxic components
Molecular Weight: Approx. 12,600 g/mol for F127
Other Ingredients: None intentionally added
Eye Contact: Rinse eyes thoroughly with water, lift eyelids, remove contact lenses, seek medical attention if irritation continues
Skin Contact: Wash affected area with soap and water, seek medical attention for persistent redness or irritation
Inhalation: Move person to fresh air, get medical attention for symptoms such as coughing or difficulty breathing
Ingestion: Rinse mouth with water, drink water to dilute, do not induce vomiting unless directed by medical personnel, seek medical advice
Key Symptoms: Minor irritation, redness, coughing
Suitable Extinguishing Media: Water spray, foam, dry chemical, carbon dioxide
Hazardous Combustion Products: Carbon monoxide, carbon dioxide, other toxic fumes
Protective Equipment: Full protective suit, self-contained breathing apparatus for high temperatures
Fire and Explosion Hazards: Not highly flammable, but product may contribute to smoke if involved in fire
Special Precautions: Avoid inhaling combustion fumes
Personal Precautions: Wear gloves, goggles, protective clothing
Spill Response: Sweep up material, place in container for disposal
Cleaning Method: Clean surface with water and detergent to remove residue
Environmental Precautions: Avoid releasing large amounts into water or soil
Disposal Info: Collect and dispose according to local regulations
Ventilation: Ventilate area to disperse any fine particulate
Handling: Use with adequate ventilation, avoid creating dust, minimize direct contact with skin and eyes
Storage Conditions: Store in tightly sealed containers in cool, dry place away from incompatible substances
Incompatible Materials: Strong oxidizers may react with product
Hygiene Advice: Wash hands after handling, change out of contaminated clothing
Bulk Storage: Limit time kept in open containers, keep tightly capped to limit contamination and moisture uptake
Exposure Limits: No established workplace exposure limit values
Engineering Controls: General lab ventilation usually sufficient, use fume hood if dusting possible
Respiratory Protection: Dust mask or respirator for airborne particles
Skin Protection: Latex, nitrile, or vinyl gloves
Eye Protection: Safety goggles or glasses
Other Protection: Lab coat, long sleeves, closed shoes
Appearance: White, flaky solid or powder
Odor: Odorless
pH: Approx. 7 (1% in water)
Melting Point: 52-57°C
Solubility: Easily soluble in water, forms viscous solutions at higher concentrations
Molecular Weight: About 12,600 g/mol (F127)
Boiling Point: Not applicable (decomposes before boiling)
Vapor Pressure: Negligible
Density: 1.1 g/cm³
Partition Coefficient: Not measured
Other Properties: Stable under normal conditions, hygroscopic
Chemical Stability: Stable under normal storage and use
Conditions to Avoid: Prolonged exposure to high temperatures, moisture
Incompatible Materials: Strong oxidants may cause degradation
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide from combustion
Polymerization: Does not self-polymerize
Reactivity: Typically non-reactive, can absorb water and clump
Acute Toxicity: Low toxicity, oral LD50 in rodents reported as >5,000 mg/kg
Irritation: Mild skin and eye irritant reported in some rare cases
Sensitization: No known sensitizing effects
Chronic Effects: No data to suggest carcinogenicity, mutagenicity, reproductive or developmental toxicity
Exposure Symptoms: Transient irritation, redness, sneezing if inhaled as dust
Medical Conditions Aggravated: Pre-existing skin or respiratory sensitivities
Ecotoxicity: Generally low hazard, not expected to bioaccumulate or cause long-term harm
Persistence: Readily biodegradable in aquatic environments
Mobility: Mobile in water, soluble material may dilute quickly
Aquatic Toxicity: No evidence of significant harm at typical doses
Bioaccumulation: Not expected to accumulate in organisms
Degradation: Expected to break down in natural environments through microbiological action
Waste Disposal: Dispose according to local, regional, or national regulations
Contaminated Packaging: Rinse containers with water, dispose as non-hazardous waste if permitted
Sewage Disposal: Avoid large-scale release to drains and public water systems
Special Disposal Requirements: Do not incinerate with regular waste, avoid landfilling in large amounts
Recovery/Reuse: Not generally recovered or reused after contamination
Regulations: Follow all applicable disposal guidelines
UN Number: Not regulated
Proper Shipping Name: Not a hazardous material
Hazard Class: Not classified
Packing Group: Not specified
Marine Pollutant: Not expected
Special Precautions: Protect from moisture during transport, seal containers tightly
Transport Regulation: Not subject to special transport controls
OSHA: Not considered hazardous
TSCA: Listed on inventory
REACH: Registered as exempt polymer in Europe
CERCLA: Not listed
SARA 313: Not subject
WHMIS: Not controlled under Canadian WHMIS
Other Regulatory Listings: Included in international inventories; check local requirements for specific country protocols
Safety Approval: Acceptable for use in pharmaceutical and laboratory settings under supervised conditions
