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Product Name: Pleuromutilin
Chemical Name: Pleuromutilin
Synonyms: 14-Hydroxypleuromutilin
CAS Number: 125-65-5
Molecular Formula: C22H34O5
Manufacturer: Contact manufacturer for specific information, typically a pharmaceutical supplier or research organization
Recommended Use: Antibiotic agent, research laboratory applications
Restrictions on Use: Not for human or veterinary drug use except under strict regulatory authority
Emergency Contact: Refer to supplier details and local poison control center
Address: See manufacturer documentation for full contact information
Classification: Acute toxicity (oral, dermal, inhalation), Eye irritation, Skin irritation
GHS Label Elements: Skull and crossbones (Toxic), Exclamation mark (Irritant)
Hazard Statements: Harmful if swallowed, causes skin and eye irritation, may cause respiratory irritation
Precautionary Statements: Avoid inhaling dust or vapors, prevent skin and eye contact, wash thoroughly after handling, use only outdoors or with good ventilation
Signal Word: Warning
Potential Health Effects: Irritation to respiratory tract, eyes, and skin; unknown allergenic potential
Chronic Exposure: No human data, animal data suggests risk at high, repeated doses
Other Hazards: Not classified as carcinogenic, mutagenic, or reproductive toxin by IARC, NTP, or OSHA
Chemical Name: Pleuromutilin
CAS Number: 125-65-5
Purity: >98% (Typical research grade)
Impurities: Trace organic solvents, possible related pleuromutilin structures
Other Components: None reported in pure product
Eye Contact: Rinse cautiously with lukewarm water for minimum 15 minutes, remove contact lenses if present, seek medical help promptly
Skin Contact: Immediately remove contaminated clothing, flush affected area with water and soap for at least 15 minutes, consult physician if irritation continues
Inhalation: Remove person to fresh air, maintain open airway, if symptoms persist consult healthcare professional
Ingestion: Rinse mouth with plenty of water, never give anything by mouth to an unconscious person, seek medical attention at once, do not induce vomiting without medical instruction
Most Important Symptoms/Effects: Irritation, potential allergy-like symptoms, nausea
Immediate Medical Attention: Possible in severe exposures; show safety data sheet to attending physician
Suitable Extinguishing Media: Water spray, carbon dioxide, dry chemical powder, alcohol-resistant foam
Special Hazards from Combustion: Carbon monoxide or dioxide, possible toxic fumes or decomposition products
Special Protective Equipment for Firefighters: Full face mask, self-contained breathing apparatus, chemical protective clothing
Fire Fighting Procedures: Move containers from area if possible, avoid inhaling smoke or fumes
Explosion Sensitivity: No data for pleuromutilin, but handle as ordinary combustible powder
Personal Precautions: Use personal protective equipment including gloves, safety goggles, and dust mask or respirator, avoid generating dust
Environmental Precautions: Prevent runoff to drains, soil, or water bodies
Methods for Cleanup: Sweep up carefully without generating dust, use damp cloth if possible, place waste in sealable containers for disposal according to local regulations
Decontamination: Clean spill area with water and detergent, ventilate area fully
Safe Handling: Do not handle until all safety precautions have been read, use in well-ventilated laboratory space or fume hood, avoid breathing dust, and avoid contact with skin or eyes
Storage Conditions: Store tightly sealed at 2-8°C in a dedicated chemical storage area, protect from direct sunlight, moisture, and incompatible materials
Special Precautions: Segregate from acids, bases, strong oxidizing agents
Incompatible Materials: Strong oxidizers, strong reducing agents, acids
Packaging Material: Use glass, plastic, or chemically resistant containers, clearly labeled
Engineering Controls: Use fume hood or local exhaust ventilation, laboratory grade airflow system recommended
Eye Protection: Chemical safety goggles complying with OSHA or EN166
Hand Protection: Disposable nitrile or neoprene gloves, avoid latex if sensitive
Skin Protection: Lab coat, closed-toe shoes, long pants, gloves
Respiratory Protection: Dust mask (minimum N95), use higher grade respirator for visible dust generation or insufficient ventilation
Exposure Limits: No established OSHA PEL or ACGIH TLV; handle as potentially hazardous
Hygiene Measures: Wash hands thoroughly after use, keep food and drink away from work area
Appearance: White to off-white crystalline powder
Odor: No distinctive odor reported
Odor Threshold: No data available
pH: Not applicable in solid form, approximate range (6-8) in solution
Melting Point/Freezing Point: 180 – 190°C
Initial Boiling Point and Boiling Range: Decomposes before boiling
Flash Point: Data not available
Evaporation Rate: Not applicable
Flammability: No data on flammability, treat as combustible dust
Upper/Lower Flammability or Explosive Limits: Not determined
Vapor Pressure: Not relevant; negligible at room temperature
Vapor Density: Not relevant
Relative Density: About 1.2 g/cm³
Solubility: Sparingly soluble in water, more soluble in organic solvents (methanol, ethanol, DMSO)
Partition Coefficient (n-octanol/water): No data
Auto-ignition Temperature: Not tested
Decomposition Temperature: Above 190°C, decomposition to toxic products possible
Viscosity: Not applicable
Chemical Stability: Stable under recommended storage conditions
Possibility of Hazardous Reactions: May react with strong oxidizers or acids
Conditions to Avoid: Heat, open flame, humidity, direct sunlight, incompatible chemicals
Incompatible Materials: Strong oxidizers, acids, strong bases
Hazardous Decomposition Products: Carbon dioxide, carbon monoxide, unidentified toxic organic compounds upon burning
Acute Toxicity: Oral rat LD50 = estimated at 300-500 mg/kg, toxicity data remains limited
Skin Corrosion/Irritation: May cause redness and irritation in direct contact
Eye Damage/Irritation: Risk of eye irritation, redness, tearing
Respiratory Sensitization: Irritation possible upon inhalation, effects age and health dependent
Skin Sensitization: Risk exists if repeated or prolonged contact occurs
Carcinogenicity: No reliable evidence of carcinogenic potential published
Germ Cell Mutagenicity: Data lacking, not known to cause mutations
Reproductive Toxicity: No direct link reported, absence of robust study data
Specific Target Organ Toxicity: At high doses, animal studies record liver and kidney changes; no known human data
Symptoms of Overexposure: Nausea, vomiting, headache, skin and respiratory irritation, possible allergic responses
Ecotoxicity: Data for pleuromutilin remains sparse, but similar antibiotics typically toxic to aquatic fauna with long-term effects
Persistence and Degradability: Likely to persist in environment, slow breakdown in soil and water due to complex organic structure
Bioaccumulative Potential: Unclear, likely low due to limited water solubility
Mobility in Soil: Adsorbs to soil particles, minimal leaching risk
Other Adverse Effects: May disturb microbial populations in sewage/wastewater and natural water systems, consequences for environmental antibiotic resistance must be considered
Waste Treatment Methods: Dispose through chemical waste contractor according to local and national laws
Contaminated Packaging: Empty containers must be triple-rinsed and punctured before disposal, follow regulatory labeling for hazardous waste
Special Instructions: Do not allow to enter drains, soils, or waterways, incinerate under controlled conditions if possible
Regulatory Requirements: Consult country, state, and local regulations for specifics, do not landfill unless authorized
UN Number: Not assigned for pleuromutilin
Proper Shipping Name: Not regulated as hazardous in small laboratory quantities, verify for bulk shipments
Transport Hazard Class: Not classified
Packing Group: Not assigned
Environmental Hazards: Not designated as marine pollutant
Special Precautions: Avoid release to environment during handling and transport, secure packaging tightly
Transport in Bulk: Not regulated under Annex II of MARPOL 73/78 and IBC Code
Other Information: Provide documentation with product identification and hazard information
TSCA Status: Not listed for general commercial use, permitted for research by specific exemption
OSHA Hazard Communication: Regulated as hazardous based on irritation, acute toxicity concerns
SARA 313: Not subject to reporting requirements
DSL/NDSL (Canada): Not listed
EINECS/ELINCS (EU): Not listed as a registered commercial chemical
California Proposition 65: Not listed
State Regulations: Varies, handle as hazardous chemical in all U.S. states
Other Regulatory Information: Controlled substance where antimicrobial distribution is subject to medical prescription, refer to local health and safety rules before use
