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Product Name: Piperaquine Phosphate
Chemical Family: Quinolines
Synonyms: 1,3-Bis[1,7-dichloro-3,4-dihydro-2-methyl-3-(4-piperazinyl)quinolin-4-yl]-1,3-propanediamine phosphate
CAS Number: 4085-31-8
EC Number: 223-771-3
Manufacturer: Contact local supplier or manufacturer
Recommended Use: Antimalarial active ingredient for pharmaceutical preparations
Restrictions on Use: Not intended for direct human consumption or use except as formulated by professionals
Classification: Acute toxicity (oral, category 4), skin irritation, eye irritation
GHS Label Elements: Signal word: Warning, Hazard pictograms: Exclamation mark
Hazard Statements: Harmful if swallowed, causes skin irritation, causes serious eye irritation
Precautionary Statements: Avoid contact with skin and eyes, wash thoroughly after handling, use personal protection equipment, store away from incompatible materials
Other Hazards: Possible respiratory irritation, environmental hazard in case of spills
Chemical Name: Piperaquine Phosphate
CAS Number: 4085-31-8
Concentration: ≥ 98% (pharmaceutical grade)
Impurities: Related substances & degradation products present in trace amounts according to certificate of analysis
Additional Ingredients: None in raw form; finished pharmaceutical may include excipients
General Advice: Remove exposed individual from area of exposure
Inhalation: Move to fresh air; seek medical attention if symptoms develop
Skin Contact: Remove contaminated clothing; rinse skin thoroughly with water and soap
Eye Contact: Rinse with plenty of water, holding eyelids open; remove contacts if present; seek immediate medical attention
Ingestion: Rinse mouth without inducing vomiting; seek prompt medical attention
Note to Physician: Symptomatic treatment and supportive therapy as needed
Suitable Extinguishing Media: Dry chemical powder, foam, carbon dioxide, water spray
Unsuitable Extinguishing Media: Water jet (may spread fire)
Special Hazards: Emits toxic fumes of carbon oxides, phosphorus oxides, chlorine compounds under combustion
Protective Equipment for Firefighters: Self-contained breathing apparatus, protective clothing
Other Information: Move unaffected containers from fire area if safe; prevent runoff to drains or waterways
Personal Precautions: Avoid inhalation and contact with skin or eyes; ventilate area
Environmental Precautions: Prevent further release or spill; avoid entry into drains, waterways, or soil
Spill Containment Methods: Use absorbent material (vermiculite, sand); sweep up and place in suitable waste container
Decontamination: Wash area thoroughly with water and detergent; collect washings for disposal
Cleanup Equipment: Wear appropriate PPE (gloves, goggles, dust mask)
Handling: Use in well-ventilated area; avoid generation of dust; do not eat, drink, or smoke during use; wash hands after handling
Storage: Store in tightly closed, labeled container in cool, dry, ventilated area; keep away from incompatible substances (oxidizers, acids); secure against unauthorized access
Incompatibilities: Reducing agents, strong bases, oxidizers
Hygiene Measures: Change out of contaminated clothing immediately; launder clothing before reuse
Engineering Controls: Use local/exhaust ventilation to control dust levels
Exposure Limits: No specific occupational exposure limits established; minimize exposure according to pharmaceutical safety practices
Personal Protective Equipment: Gloves (nitrile or PVC), safety glasses or goggles, lab coat or apron, dust mask or respirator (if dust produced)
Environmental Controls: Prevent release to the environment; use closed handling system if possible
Appearance: White to pale yellow, crystalline powder
Molecular Formula: C29H40Cl2N6O4P
Molecular Weight: 653.56 g/mol
Odor: Odorless
pH: 4.8–6.5 (1% solution in water)
Solubility: Freely soluble in water
Melting Point: 285–290 °C (decomposes)
Boiling Point: Not applicable (decomposes)
Partition Coefficient (log Kow): Data not available
Vapor Pressure: Negligible
Density: Approx. 1.4 g/cm³
Flash Point: Not available
Autoignition Temperature: Not available
Explosive Properties: Not classified as explosive
Oxidizing Properties: Not classified as oxidizer
Chemical Stability: Stable under normal conditions of use and storage
Reactivity: No hazardous reactivity anticipated under recommended conditions
Hazardous Reactions: Decomposes at elevated temperatures producing toxic gases
Incompatible Materials: Strong oxidizers, acids, bases
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, nitrogen oxides, chlorine compounds, phosphorus oxides
Conditions to Avoid: Heat, moisture, strong light, incompatible substances
Likely Routes of Exposure: Ingestion, inhalation, skin, and eye contact
Acute Toxicity: Harmful if swallowed; LD50 (oral, rat): approx. 500–1000 mg/kg
Skin Corrosion/Irritation: Causes moderate irritation based on analog data
Serious Eye Damage/Irritation: Causes irritation and reddening
Respiratory or Skin Sensitization: No data; precaution is best
Chronic Effects: Long-term exposure may affect blood, liver, nervous system
Carcinogenicity: Not classified as carcinogen by IARC, NTP, OSHA
Reproductive Toxicity: No specific data, precautionary measures advised
Other Information: Allergic reactions and respiratory effects possible in sensitive individuals
Ecotoxicity: Data lacking; anticipated to have adverse effects on aquatic organisms
Persistence and Degradability: Likely to persist in the environment due to chemical stability
Bioaccumulation Potential: Potential for bioaccumulation cannot be ruled out
Mobility in Soil: No strong adsorption; movement through soil possible
Other Adverse Effects: Prevent direct release into soil, water, and drains to avoid possible contamination
Disposal Methods: Dispose in accordance with national and local regulations
Waste Treatment: Burn in chemical incinerator with afterburner and scrubber, or send to licensed waste disposal facility
Container Disposal: Rinse and dispose of containers as hazardous chemical waste; do not reuse
Additional Considerations: Incineration preferred for active pharmaceutical ingredients
UN Number: Not regulated as dangerous goods for most global transport modes
UN Proper Shipping Name: Not classified
Transport Hazard Class: Not classified
Packing Group: Not assigned
Special Precautions: Avoid dust generation; use adequate packaging to avoid physical damage
Environmental Hazards: Not listed as a marine pollutant
Transport in Bulk: Not applicable
International Regulations: Listed under pharmaceutical regulations in many countries, not specifically listed under chemical inventories
EU Regulations: Not classified for supply/use as hazardous; included in medicinal products regulation
US Regulations: Not subject to specific TSCA, CERCLA, or SARA listings
Workplace Safety: Pharmaceutical safety practices apply
Other Information: Consult local, regional, and national authorities for detailed and up-to-date regulations pertaining to manufacture, handling, and disposal
