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Product Name: Piperacillin Acid, Piperacillin (Acid) Monohydrate
Chemical Family: Beta-lactam antibiotic
Synonyms: Piperacillin acid monohydrate, U63221, PRL-121
CAS Number: 60696-78-6
Manufacturer/Supplier: Pharmaceutical manufacturing companies and chemical distributors
Recommended Uses: Research and pharmaceutical synthesis
Contact Information: Emergency number and address of manufacturer or supplier
GHS Classification: Skin sensitization (Category 1), Eye irritation (Category 2A), Specific target organ toxicity (Category 3)
Signal Word: Warning
Hazard Statements: May cause allergic skin reaction, may cause irritation to eyes and respiratory system
Pictograms: Exclamation mark, Health hazard
Precautionary Statements: Avoid breathing dust, wear protective gloves, avoid contact with eyes, wash thoroughly after handling, seek medical attention if adverse symptoms occur
Routes of Exposure: Inhalation, ingestion, skin and eye contact
Chemical Name: Piperacillin Acid
CAS Number: 60696-78-6
Percentage: 98-100% (as pure compound for lab scale)
Impurities: Related substances below regulatory limits for pharmaceutical ingredients
Additives: No intentionally added additives
Inhalation: Move person to fresh air, keep at rest, seek medical attention if symptoms like coughing, trouble breathing, or wheezing develop
Skin Contact: Remove contaminated clothing, rinse skin thoroughly with water for at least fifteen minutes, use soap if possible, get medical help if irritation develops or persists
Eye Contact: Rinse eyes gently with water for several minutes, remove contact lenses if present and easy to do, continue rinsing, seek medical help if irritation continues
Ingestion: Rinse mouth with water, never induce vomiting, seek immediate medical advice, provide medical personnel with product information
Most Important Symptoms/Effects: Allergic reactions, rash, respiratory symptoms
Immediate Medical Attention/Special Treatment Needed: For suspected allergic reaction (anaphylaxis) administer epinephrine and call emergency services
Suitable Extinguishing Media: Water spray, dry chemical powder, foam, carbon dioxide
Unsuitable Extinguishing Media: Avoid high volume water jet that may spread powder
Specific Hazards: Thermal decomposition may release nitrogen oxides, sulfur oxides, carbon oxides, hydrogen chloride
Protection for Firefighters: Wear self-contained breathing apparatus, protective suit, avoid inhaling combustion vapors
Fire/Explosion Hazard: Not flammable under normal conditions; fine particles may form explosive dust clouds in air
Personal Precautions: Ventilate area, avoid dust formation, avoid breathing dust, use personal protective equipment including gloves, goggles, and respirator
Environmental Precautions: Prevent entry into drains, sewers, waterways; inform authorities if significant release occurs
Methods for Containment and Cleaning: Sweep up without generating dust, place in suitable label container for disposal, wash contaminated area thoroughly with water
Emergency Procedures: Evacuate unnecessary personnel, control access to affected area
Safe Handling: Minimize dust generation, use in well-ventilated area, avoid contact with skin and eyes, wear required protective equipment, avoid inhalation
Storage Conditions: Store in cool, dry, well-ventilated place, away from incompatible substances like oxidizing agents and acids, keep tightly closed in original container
Storage Temperature: Recommended at 2-8°C to maintain chemical stability
Incompatible Materials: Strong acids, strong oxidizers, bases
Special Requirements: Protect from moisture, light, and excessive heat
Exposure Limits: No occupational exposure limits established under OSHA, ACGIH, or NIOSH
Engineering Controls: Use local exhaust ventilation to limit airborne dust and keep exposure below recommended levels
Personal Protective Equipment:
Appearance: White or off-white crystalline powder
Odor: Odorless
Odor Threshold: Not relevant
pH: 4.0-6.0 (1% solution in water)
Melting Point/Freezing Point: 197-202°C (decomposition)
Boiling Point: Decomposition before boiling
Flash Point: Not applicable
Evaporation Rate: Not applicable
Flammability: Not flammable
Vapor Pressure: Negligible at room temperature
Vapor Density: Not available
Relative Density: 1.5-1.7 g/cm³
Solubility: Freely soluble in water, sparingly soluble in methanol, practically insoluble in organic solvents
Partition Coefficient (log Pow): Not determined
Auto-ignition Temperature: Not established
Decomposition Temperature: Above 190°C
Viscosity: Not applicable for solid
Chemical Stability: Stable under recommended storage conditions
Hazardous Reactions: Risk of hazardous reactions with oxidizing agents, acids, strong bases
Conditions to Avoid: Exposure to moisture, heat, and light accelerates decomposition
Incompatible Materials: Strong oxidizing agents, strong acids, bases
Hazardous Decomposition Products: Nitrogen oxides, sulfur oxides, hydrogen chloride, carbon oxides
Acute Toxicity: Data limited; oral LD50 in rats >5000 mg/kg estimated
Skin Corrosion/Irritation: May cause mild skin irritation; repeated or prolonged contact increases risk
Serious Eye Damage: Potential for moderate irritation
Respiratory Sensitization: May trigger respiratory symptoms in sensitive individuals
Skin Sensitization: Documented risk of allergic skin responses, particularly in previously sensitized individuals
Germ Cell Mutagenicity: No data indicating mutagenic hazard
Carcinogenicity: Not classified as carcinogen by IARC, NTP, ACGIH, or OSHA
Reproductive Toxicity: No clear evidence in available studies
STOT (Specific Target Organ Toxicity) – Single/Repeated Exposure: Possible respiratory symptoms, exacerbation of asthma or allergy
Aspiration Hazard: Unlikely due to solid state
Other Effects: Antibiotics in this class may trigger hypersensitive or allergic reactions, including anaphylaxis
Ecotoxicity: Data scarce; antibiotics pose risk to aquatic microorganisms and may promote resistance development in environment
Persistence and Degradability: Not readily biodegradable
Bioaccumulative Potential: No significant bioaccumulation expected
Mobility in Soil: Expected to have moderate mobility, dissolves in water, can leach through soil
Other Adverse Effects: Emission to water bodies should be avoided due to risks of antibiotic resistance selection in natural bacterial populations
Disposal Method: Dispose of as hazardous pharmaceutical waste by incineration or in accordance with local, regional, and federal regulations
Contaminated Packaging: Empty containers must be triple rinsed and punctured before disposal, handled as hazardous waste
Recommended Waste Handling: Do not discharge to sewage systems, surface water, or natural environment
Special Considerations: Follow state and federal guidelines for pharmaceutical chemicals
UN Number: Not classified as dangerous good for transport
Proper Shipping Name: Not applicable for non-hazardous sample quantities
Transport Hazard Class: Not regulated
Packing Group: Not assigned
Special Precautions: Avoid air and moisture exposure, keep container sealed during transport
Environmental Hazards: Not marine pollutant
TSCA Inventory: Not listed for pharmaceutical grade substances
REACH Status: Not registered for bulk production in EU
OSHA Hazardous Chemical: Regulated as a hazardous chemical in workplace
SARA Title III: Not subject to reporting requirements
California Prop 65: Not listed
WHMIS (Canada): Controlled Product; laboratory use only
EU Classification: Not classified as a dangerous substance under CLP for standard research use
AICS (Australia): Not specifically listed for commercial quantities
