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Product Name: Pipemidic Acid Trihydrate
Chemical Name: 8-Ethyl-5,8-dihydro-5-oxo-2-piperazinoquinoline-3-carboxylic acid trihydrate
CAS Number: 51940-44-4
Molecular Formula: C14H17N3O5 · 3H2O
Molecular Weight: 357.36 g/mol
Manufacturer/Supplier: Contact information as provided by supplier or manufacturer
Recommended Use: Pharmaceutical raw material, antibacterial agent
Emergency Contact: National poison center or local emergency service
Classification: Harmful if swallowed, may cause respiratory irritation, risk of serious damage to eyes, sensitization possible through skin contact
Hazard Symbols: Xn (Harmful), Xi (Irritant)
Signal Word: Warning
Potential Health Effects: Inhalation causes cough and respiratory irritation, ingestion leads to gastrointestinal upset, skin contact may provoke irritation, eye contact can result in severe injury or long-term damage
Routes of Exposure: Inhalation, ingestion, skin and eye contact
Precautionary Statements: Avoid breathing dust, wear protective gloves and glasses, wash exposed skin thoroughly
Chemical Identity: Pipemidic Acid Trihydrate
Concentration: >95%
Impurities: Trace amount of synthesis-related byproducts, water (trihydrate form)
Additives: None
Other Components: Not applicable
Inhalation: Remove to fresh air, keep at rest, seek medical attention if symptoms occur
Skin Contact: Remove contaminated clothing, wash skin with soap and water, get medical advice if irritation persists
Eye Contact: Rinse cautiously with water for over 15 minutes, remove contact lenses if possible, open eyelids widely, get medical attention immediately
Ingestion: Rinse mouth with water, do not induce vomiting unless instructed by a medical professional, seek medical advice quickly
Symptoms and Effects: May cause irritation, redness, nausea, dizziness in unprotected situations
Suitable Extinguishing Media: Water spray, alcohol-resistant foam, dry chemical powder, carbon dioxide
Unsuitable Extinguishing Media: High pressure water jet may spread the powder
Hazardous Combustion Products: Nitrogen oxides, carbon monoxide, carbon dioxide, noxious fumes
Special Equipment for Firefighters: Full protective clothing and self-contained breathing apparatus
Precautions: Evacuate area, use water spray to cool containers near flames, avoid inhaling combustion gases
Personal Precautions: Avoid breathing dust, ventilate affected area, wear protective gloves, goggles, and dust mask
Environmental Precautions: Prevent further leakage, stop any entering into drains, ground, or water sources
Cleaning Methods: Collect spilled substance mechanically, place in labeled waste container, wipe area with damp cloth, dispose in accordance with local regulation
Disposal: Do not flush into sewer system, avoid dispersal of dust in the air
Handling: Use in well-ventilated place, avoid formation of dust, handle in accordance with good industrial hygiene practices, wash hands after handling
Storage Conditions: Store in tightly closed original container, in a dry, cool, and well-ventilated place, keep away from strong acids and bases, protect from sunlight and heat
Incompatible Materials: Strong oxidizing agents, strong acids, alkalis
Special Requirements: Keep out of reach of children and unauthorized persons, check label for storage temperature
Engineering Controls: Use process enclosure, local exhaust ventilation, or other engineering controls to keep airborne levels below recommended exposure limits
Respiratory Protection: If airborne exposure is possible, use approved dust masks or respirators
Hand Protection: Wear suitable gloves such as nitrile or latex
Eye Protection: Use safety glasses with side shields or goggles
Skin and Body Protection: Wear lab coat, apron, or protective clothing
Hygiene Measures: Wash hands, forearms, and face thoroughly after handling chemical products, before eating, smoking or using the lavatory
Appearance: White or light yellow crystalline powder
Odor: Odorless
Melting Point: 258–259°C (decomposes)
Boiling Point: Not applicable (decomposes before boiling)
Solubility: Soluble in water, slightly soluble in ethanol, insoluble in ether or benzene
pH: About 5.0–7.0 (1% solution in water)
Vapor Pressure: Not established
Density: 1.6–1.7 g/cm³
Partition Coefficient (log Kow): Not available
Other Data: Forms stable hydrates with water, loses water at high temperatures
Chemical Stability: Stable under recommended storage conditions, decomposes on exposure to strong sunlight or high temperatures
Possibility of Hazardous Reactions: No dangerous reactions known under normal use
Conditions to Avoid: Heat, moisture, exposure to light
Incompatible Materials: Oxidizing agents, acids, alkalis
Decomposition Products: Nitrogen oxides, carbon monoxide, carbon dioxide, irritating fumes
Acute Toxicity, Oral: LD50 (rat): 430 mg/kg
Acute Toxicity, Dermal: No specific data, based on components expect low hazard
Acute Toxicity, Inhalation: Can irritate the respiratory tract if excessive dust is inhaled
Skin Corrosion/Irritation: Irritant based on animal studies
Serious Eye Damage/Irritation: Risk of eye damage, prolonged contact causes severe irritation
Respiratory or Skin Sensitization: Possible skin sensitization based on structure, rare respiratory reactions
Other Effects: May affect liver and kidneys after high or prolonged exposure
Aquatic Toxicity: LC50 for fish (96 h) >100 mg/L, low acute toxicity
Persistence and Degradability: Moderate persistence, some biodegradability
Bioaccumulative Potential: Low Due to molecular structure
Mobility in Soil: Not expected to leach under recommended handling
Remarks: Avoid releasing large quantities into the environment, follows standard procedures for pharmaceuticals
Waste Disposal Method: Dispose of contents in licensed hazardous waste facility
Packaging Disposal: Empty containers should be handled as hazardous waste and disposed in accordance with local regulations
Special Instructions: Do not discharge into drains, soil, or waterways, follow local, regional, and national guidelines
UN Number: Not classified as dangerous under UN, ADR, RID, IMDG, or IATA transport regulations
Proper Shipping Name: Pipemidic Acid Trihydrate
Transport Hazard Class: None regulated
Packing Group: None
Special Precautions: Minimize dust generation, ensure container integrity during loading and transport
Labelling: No specific transport pictogram mandatory
Regulatory Status: Not classified as hazardous for international transport
US Federal Regulations: Not listed under TSCA, CERCLA, SARA Title III
EU Regulations: Substance not listed in Annex XIV of REACH, does not have specific EU harmonized classification
Canadian Regulations: DSL/NDSL status to be confirmed
Local Laws: Must comply with national and local regulations regarding workplace health, safety and environmental protection
