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Product Name: Phenylephrine Hydrochloride
Chemical Name: (R)-3-[(1-hydroxy-2-methylamino)ethyl]phenol hydrochloride
Synonyms: Phenylephrine HCl, Neosynephrine
CAS Number: 59-42-7
Molecular Formula: C9H13NO2·HCl
Molecular Weight: 203.67 g/mol
Intended Use: Vasoconstrictor, pharmaceutical ingredient
Manufacturer: Identified per shipment
Contact Details: Refer to packaging or supplier’s emergency contact
Emergency Phone Number: Designated on supply documentation
Hazard Classification: Acute toxicity (oral, dermal, inhalation), Eye irritation, Skin irritation
Signal Word: Warning
Hazard Statements: Harmful if swallowed, contact may cause mild to moderate skin and eye irritation
Pictogram: Exclamation mark (GHS07)
Precautionary Statements: Avoid breathing dust or powder, Do not eat, drink, or smoke during use, Wash skin thoroughly after handling, Wear protective gloves/protective clothing/eye protection
Routes of Exposure: Ingestion, inhalation, skin contact, eye contact
Target Organs: Central nervous system, eyes, skin
Chemical Name: Phenylephrine Hydrochloride
CAS Number: 59-42-7
Content: >99% (as pure substance)
Impurities & Stabilizers: Trace process impurities may remain below 0.1% each, not considered hazardous per available data
Additives: None
Inhalation: Remove person to fresh air immediately, keep at rest, provide oxygen if shortness of breath occurs, get medical attention.
Skin Contact: Remove contaminated clothing, wash skin with plenty of water and mild soap for fifteen minutes, seek medical advice if rash or irritation persists.
Eye Contact: Rinse with running water for at least fifteen minutes while lifting eyelids, remove contact lenses if possible, get prompt medical evaluation.
Ingestion: Rinse mouth, do not induce vomiting, seek medical help quickly, provide medical personnel with MSDS and details of exposure.
Most Important Symptoms: Irritation of eyes and mucosal membranes, possible confusion, palpitations, hypertension
Advice for Medical Personnel: Symptomatic treatment as required; consider effects on blood pressure and heart rate.
Suitable Extinguishing Media: Water spray, dry chemical, foam, or carbon dioxide
Non-suitable Media: Do not use direct water jet on solid chemical fires
Specific Hazards: May release toxic fumes of nitrogen oxides, hydrogen chloride, carbon monoxide and carbon dioxide during burning
Protective Equipment: Firefighters need self-contained breathing apparatus (SCBA) and full personal protective clothing
Fire Fighting Instructions: Control run-off, cool exposed containers with water spray
Thermal Decomposition: Can exude irritating or harmful gases if flame or heat threshold exceeded.
Personal Precautions: Evacuate unnecessary personnel, wear chemical-resistant gloves, protective goggles, suitable respirator or mask
Spill Response: Ventilate area, prevent dust formation, avoid breathing dust
Cleanup Methods: Sweep up spilled material gently to avoid dust, place in closed containers for disposal, wipe residue with damp cloth
Environmental Precautions: Prevent entry into watercourses, drains, or sewers; report significant spills to authorities
Decontamination: Wash area with water and mild detergent after clean-up.
Handling: Avoid inhalation of powder, protect from skin and eye contact, use in well-ventilated area, handle away from sources of ignition
Hygiene Measures: Wash hands before eating, drinking, smoking, or using the restroom; remove contaminated clothing quickly
Storage Conditions: Keep container tightly closed, store in cool, dry, well-ventilated place, protect from direct sunlight and heat
Incompatible Materials: Strong oxidizing agents, strong acids, bases
Packing Materials: Use non-reactive, sealed packaging such as glass, HDPE or polypropylene
Special Precautions: Control access, maintain separation from incompatible substances.
Occupational Exposure Limit: No specific limit established; general dust limit applies (10 mg/m³ for total dust, 5 mg/m³ for respirable fraction)
Engineering Controls: Local exhaust ventilation, fume hood in laboratories, handle in closed system if possible
Eye Protection: Safety glasses with side shields or chemical splash goggles
Hand Protection: Nitrile or neoprene gloves, regularly washed
Skin Protection: Laboratory coat or chemical-resistant coveralls
Respiratory Protection: Suitable dust mask or respirator for handling powder
Environmental Exposure Controls: Use procedures to prevent release into environment, monitor spills and emissions.
Appearance: White crystalline powder
Odor: Odorless or faint chemical smell
Melting Point: 140–145 °C (decomposition begins beyond this range)
Boiling Point: Not applicable, decomposes before boiling
Solubility: Freely soluble in water, slightly soluble in ethanol
pH: 4.5–5.5 for aqueous solution (1% w/v)
Vapor Pressure: Negligible at room temperature
Partition Coefficient (log Kow): About -1.2
Flash Point: No data, non-flammable as solid
Auto-ignition Temperature: Not determined
Chemical Stability: Stable under normal storage and handling conditions
Hazardous Reactions: Reacts with strong oxidizers, risk of exothermic reaction
Conditions to Avoid: Excessive heat, sources of ignition, prolonged exposure to light, moisture
Hazardous Decomposition Products: Hydrogen chloride, nitrogen oxides, carbon oxides upon combustion or thermal decomposition
Polymerization: Not known to occur
Acute Toxicity: Oral LD50 (rat) ~ 350 mg/kg; effects: impulsiveness, increased heart rate, tremors
Skin Corrosion/Irritation: May cause mild and reversible irritation; not corrosive
Serious Eye Damage/Irritation: Possible redness and tearing; usually reversible
Respiratory or Skin Sensitization: Not classified as sensitizer; individuals might experience allergic reaction upon repeated contact
Chronic Toxicity: May increase blood pressure, risk of arrhythmias with sustained exposure
Carcinogenicity, Mutagenicity, Reproductive Toxicity: No studies show significant risk at normal exposures; not classified as carcinogen by IARC or NTP
Target Organ Effects: Cardiovascular and nervous systems, possible acute hypertension or arrhythmias.
Ecotoxicity: Toxic to aquatic organisms at elevated concentrations; LC50 (fish, 96 hr): >100 mg/L (low aquatic hazard at pharmaceutical concentrations)
Persistence and Degradability: Readily degraded in environment, low potential for bioaccumulation, half-life estimates vary by environmental context
Bioaccumulation Potential: Low based on octanol-water partitioning
Mobility in Soil: Likely to leach through soil at significant spills due to high solubility
Other Harmful Effects: Minimal environmental persistence expected with routine, responsible use; wastewater treatment removes most before river or lake entry.
Waste Treatment Methods: Incineration in chemical waste facility suited for organic pharmaceutical compounds
Product Disposal: Dispose of material and packaging as hazardous waste per local regulations, limit release to environment
Contaminated Container Disposal: Rinse thoroughly, deface labeling, offer recycling if available or manage as hazardous waste
Precautions: Do not discharge unneutralized product into sewers or drains; consult local authority for best practices
UN Number: Not regulated for transport
Proper Shipping Name: Phenylephrine hydrochloride (pharmaceutical compound, not considered hazardous for transport under most regulatory regimes)
Transport Hazard Class: Not classified
Packing Group: Not assigned
Environmental Hazards: No specific hazards
Special Precautions for User: Transport in sealed container, protect from moisture and light, comply with general safety protocols for chemicals.
Labeling Requirements: Hazard warnings required under OSHA GHS standard in U.S., similar in EU and Asia
Inventory Listings: Listed in U.S. TSCA, EINECS/ELINCS (Europe), AICS (Australia), DSL/NDSL (Canada), ENCS (Japan)
Health, Safety, Environmental Regulations: Compliance required with local and regional pharmaceutical and chemical control legislation
Other Requirements: Ensure workplace right-to-know information is available to all staff handling material; keep MSDS accessible; regular training in chemical hygiene and emergency protocols recommended.
