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Product Name: Phenylbutazone
Chemical Formula: C19H20N2O2
Synonyms: Butazolidin, Butadione, PBZ
CAS Number: 50-33-9
Intended Use: Pharmaceutical anti-inflammatory agent, veterinary medicine
Manufacturer/Supplier: Contact details provided on label
Emergency Phone: Refer to local poison control center or supplier number
Recommended Restrictions: Not for human use except under prescription; not suited for food-producing animals in many regions
GHS Classification: Acute toxicity (oral, dermal), eye irritation, specific target organ toxicity
Hazard Pictograms: Exclamation mark, Health hazard
Signal Word: Warning
Hazard Statements: Harmful if swallowed, causes serious eye irritation, may cause damage to blood, kidney, liver through prolonged exposure
Precautionary Statements: Avoid breathing dust, wear gloves, wash hands after handling, keep away from food and drink
Chemical Name: Phenylbutazone
Common Name: PBZ
Concentration: ≥99%
Impurities: Minor related substances per batch, non-hazardous stabilizers may be present
Other Ingredients: None required for labeling at technical grade purity
Inhalation: Move to fresh air, monitor for respiratory distress, seek medical attention if symptoms persist
Skin Contact: Wash thoroughly with soap and water, remove contaminated clothing, seek care if irritation develops
Eye Contact: Flush eyes with water for at least fifteen minutes, keep eyelids open, get immediate medical help
Ingestion: Rinse mouth, do not induce vomiting, seek medical care without delay, show MSDS to health personnel
Suitable Extinguishing Media: Water spray, dry chemical, foam, carbon dioxide
Hazards Arising from Fire: Generates toxic fumes including oxides of carbon and nitrogen
Protective Equipment for Firefighters: Full protective gear, self-contained breathing apparatus
Other Advice: Control run-off, prevent contamination of water sources, evacuate area if combustion releases heavy fumes
Personal Precautions: Avoid inhalation or contact, ventilate area, use personal protective equipment
Environmental Precautions: Prevent spillage from reaching drains, aquifers, or soil
Methods for Cleanup: Sweep or soak up with inert absorbent, collect in suitable container for disposal, wash site of spillage with water and detergent
Other Advice: Use spill control materials, avoid dust generation, notify authorities if large amounts escape
Handling: Use in well-ventilated locations, keep containers sealed, avoid dust and airborne particles, do not ingest, wash after handling
Storage: Store in a cool, dry place away from incompatible materials such as oxidants or acids, keep original container tightly closed, keep out of reach of children and unauthorized personnel, maintain at recommended temperature to preserve stability, label containers clearly and avoid storage near food, water, or animal feed
Exposure Limits: No established occupational exposure limits for phenylbutazone, keep as low as reasonably achievable
Ventilation: Work with local exhaust or general ventilation systems
Respiratory Protection: Wear a NIOSH-approved mask or particulate respirator if dust forms
Skin Protection: Chemical-resistant gloves (nitrile, neoprene), long-sleeved protective clothing
Eye Protection: Safety glasses with side-shields, splash-proof goggles for bulk handling
Hygiene Measures: Wash thoroughly after handling, do not eat or smoke while working, keep contaminated clothing away from personal items
Appearance: White to off-white crystalline powder
Odor: Practically odorless
pH: Not applicable (insoluble in water)
Melting Point: 105–110°C
Boiling Point: Not available, decomposes before boiling
Flash Point: Not determined (non-volatile solid)
Solubility: Practically insoluble in water, soluble in organic solvents (acetone, ethanol, chloroform)
Density: 1.148 g/cm³ (25°C)
Vapor Pressure: Negligible at room temperature
Partition Coefficient (log Pow): Approximately 4.1
Chemical Stability: Stable under recommended storage and handling conditions, sensitive to excess moisture and heat
Possible Hazardous Reactions: Test shows no hazardous polymerization
Conditions to Avoid: Contact with acids, oxidizing agents, strong bases, excessive temperatures, high humidity
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, nitrogen oxides may be released on combustion or thermal decomposition
Acute Toxicity: LD50 (oral, rat) about 660 mg/kg; may cause gastrointestinal, kidney and liver effects on ingestion
Routes of Exposure: Inhalation, skin and eye contact, ingestion
Symptoms: Headache, dizziness, nausea, vomiting, abdominal pain, renal dysfunction, anemia, allergic reactions
Chronic Effects: Prolonged exposure causes bone marrow suppression, blood disorders (such as agranulocytosis), renal and hepatic damage
Carcinogenicity: Not classified as carcinogenic by IARC, NTP or OSHA
Other Data: Avoid use in pregnant women, lactating women, or those with a history of allergy to NSAIDs
Ecotoxicity: Toxic to aquatic organisms, significant risk to fish and invertebrates if released into water
Persistence and Degradability: Not rapidly biodegradable, tends to persist in environment
Bioaccumulative Potential: May accumulate in aquatic species, high log Pow shows risk for bioaccumulation
Mobility in Soil: Low water solubility limits mobility, tends to bind to soil and sediment
Other Information: Avoid contamination of surface waters and soil, inappropriate disposal causes environmental harm
Product Waste: Dispose as hazardous pharmaceutical waste, follow local, regional and national guidelines
Contaminated Packaging: Triple rinse, then offer for proper recycling or disposal by licensed facility
Special Procedures: Do not discharge to sewer, water courses or landfills not permitted for hazardous chemical waste
Other Advice: Incineration under controlled conditions preferred if allowed by regulation
UN Number: Not classified as dangerous goods for land, air, or sea transport under most international regulations
Proper Shipping Name: Phenylbutazone
Transport Hazard Class: Not regulated
Packing Group: Not assigned
Environmental Hazards: Avoid release to environment during transport
Precautions: Keep in original container, secure load, prevent spillage during transit, clearly label all containers
Regulated Status: Listed under several pharmaceutical and chemical regulations; banned for use in food-producing animals in US, EU, and other regions
Inventory Listings: Listed on TSCA, EINECS/ELINCS, DSL, AICS and other national inventories
Workplace Controls: Subject to workplace chemical safety standards, employer must provide safety training and personal protective equipment
Other Regulation: Veterinary use limited or prohibited in many jurisdictions, prescription status varies by country, requires tracking under poison scheduling in Australia, Canada, and EU
