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Product Name: (-)-Phenylbenzoyl Corey Lactone - P-Phenylbenzoyl Corey Lactone
CAS Number: 99077-79-1
Synonyms: Corey Lactone, Corey Benzyllactone, P-Phenylbenzoyl derivative
Molecular Formula: C20H14O3
Molecular Weight: 302.33 g/mol
Recommended Use: Chemical synthesis, pharmaceutical intermediate, organic research reagent
Supplier Identification: Chemical distribution company address, contact phone, Emergency contact (CHEMTREC or local Poison Control)
Emergency Overview: Off-white to pale yellow powder with faint aromatic odor, used in specialty chemical laboratory settings
GHS Classification: Skin Irritant (Category 2), Eye Irritant (Category 2A), Specific target organ toxicity - single exposure (Category 3), Not listed as a carcinogen by IARC, NTP, or OSHA
Label Elements: Signal Word: Warning
Hazard Statements: Causes skin and eye irritation, may cause respiratory irritation
Precautionary Statements: Avoid direct contact, use under appropriate exhaust/ventilation, wear protective equipment
Potential Health Effects: Inhalation may cause throat and lung irritation, contact with skin or eyes may provoke redness, stinging, or burning; ingestion may be harmful
Physical Hazards: Dust may form explosive mixture with air if finely divided
Environmental Hazards: Not acutely hazardous to aquatic life, but persistence not fully studied
Chemical Name: (-)-Phenylbenzoyl Corey Lactone
Chemical Formula: C20H14O3
Purity: >95% (typical for research grade)
Impurities: Trace benzoyl derivatives (<1%), minimal unknown organic compounds
Other Ingredients: None intentionally present
CAS Number: 99077-79-1
General Advice: Move exposed person to well-ventilated area, remove contaminated clothing
Eye Contact: Flush eyes with plenty of water for at least 15 minutes, hold eyelids apart; seek medical attention if irritation remains
Skin Contact: Wash affected area thoroughly with soap and water, rinse for several minutes; get medical attention for persistent redness
Inhalation: Remove victim from exposure, get medical help if symptoms such as cough or breathing difficulty develop
Ingestion: Rinse mouth, drink water to dilute; do not induce vomiting; call physician
Note to Physician: Symptomatic and supportive treatment, no specific antidote reported
Suitable Extinguishing Media: Dry chemical, carbon dioxide, alcohol-resistant foam, water spray for larger fires
Specific Hazards Arising: May release toxic fumes of carbon monoxide, carbon dioxide, benzoyl compounds under combustion
Special Protective Equipment: Firefighters should wear self-contained breathing apparatus, full protective gear
Explosion Risk: Accumulated dust may ignite, take precautions to minimize dust clouds
Firefighting Procedures: Isolate area, cool containers exposed to flame, prevent water runoff from contaminating drains or waterways
Personal Precautions: Wear respiratory mask, chemical goggles, protective gloves, avoid raising dust
Environmental Precautions: Prevent entry into drains, surface waters, and soil
Cleanup Methods: Collect material using spark-proof tools, sweep up, and transfer to waste container; wash spill site after cleanup
Decontamination: Wash surfaces with soap and plenty of water, ventilate confined areas
Disposal: Follow local, regional, and national hazardous waste regulations
Precautions for Safe Handling: Handle in chemical fume hood, avoid breathing dust or vapors, minimize dust generation
Advice on Safe Handling: Use grounding and bonding for transfer to reduce static discharge possibility
Storage Conditions: Keep in tightly closed container, dry, cool, and well-ventilated place
Incompatible Materials: Strong acids, strong bases, strong oxidizing agents
Storage Precautions: Protect from direct sunlight and moisture,
Specific End Uses: Used only by trained personnel in properly equipped laboratories
Occupational Exposure Limits: No established OSHA or ACGIH limits for this material
Engineering Controls: Use laboratory fume hood, adequate ventilation
Personal Protective Equipment: Safety goggles or face shield, chemical-resistant gloves (nitrile or neoprene), lab coat
Respiratory Protection: NIOSH-approved dust mask, especially during powder handling
Hygiene Measures: Wash hands thoroughly after handling, avoid food or drink in work area, remove contaminated clothing and launder before reuse
Appearance: Solid powder, off-white to pale yellow
Odor: Faint aromatic odor
Odor Threshold: Not determined
pH: Not applicable
Melting Point: Approximately 205-210°C
Boiling Point: Decomposes before boiling
Flash Point: Not available
Evaporation Rate: Not determined (solid)
Flammability: May form combustible dust
Vapor Pressure: Not applicable
Vapor Density: Not applicable
Relative Density: ~1.3 g/cm3
Solubility: Poor in water, soluble in dichloromethane, chloroform, acetone, and other organics
Partition Coefficient (log Kow): Not determined
Auto-ignition Temperature: Not available
Decomposition Temperature: >205°C
Viscosity: Not applicable
Chemical Stability: Stable under recommended storage conditions
Reactivity: Inert to most laboratory reagents at room temperature
Hazardous Reactions: Contact with oxidizers may cause combustion
Conditions to Avoid: Moisture, elevated heat, open flames, incompatible chemicals
Decomposition Products: Carbon monoxide, carbon dioxide, benzoyl derivatives
Polymerization: Not known to polymerize
Acute Toxicity: Data limited, estimated low mammalian toxicity (rat oral LD50 >2000 mg/kg typical for similar lactones)
Skin Corrosion/Irritation: May cause irritation, no delayed effects expected
Serious Eye Damage/Irritation: Can provoke irritation, lacrimation, redness
Respiratory Sensitization: Dust may cause temporary respiratory discomfort
Chronic Effects: No chronic or reproductive toxicity reported, not mutagenic in standard Ames test
Carcinogenicity: Not classified as carcinogenic by NTP, OSHA, or IARC
Potential Routes of Exposure: Inhalation, skin contact, eye contact, ingestion
Symptoms: Redness, itching, coughing, sneezing upon exposure, possible nausea if ingested
Ecotoxicity: No data for this compound, but structurally similar lactones show low to moderate toxicity in aquatic organisms (fish LC50 >100 mg/L)
Persistence and Degradability: May persist as recalcitrant aromatic compounds in environment, limited biodegradation
Bioaccumulative Potential: Not expected to bioaccumulate due to limited solubility and expected metabolism
Mobility in Soil: Strong binding to soils, low mobility predicted
Other Adverse Effects: Not identified as endocrine disruptor or marine pollutant
Waste Treatment Methods: Dissolve or mix residue with a combustible solvent and dispose by incineration in accordance with local and national guidelines
Contaminated Packaging: Empty containers should be triple rinsed before disposal, puncture to prevent reuse
Special Precautions: Do not landfill bulk powder, avoid disposal into environment
Regulatory Disposal Code: Follow local hazardous waste codes for organic laboratory chemicals
UN Number: Not classified as a dangerous good under UN transport regulations
UN Proper Shipping Name: Not regulated
Transport Hazard Class: Not regulated
Packing Group: Not applicable
Environmental Hazards: Not considered marine pollutant by IMDG
Transport Special Precautions: Avoid generating dust, package securely in sealed, labeled containers
DOT/IATA/IMDG Information: Non-hazardous for air or ground transportation under normal laboratory quantities
OSHA: Not specifically regulated under Hazard Communication standard
TSCA: Not listed as a commercial chemical substance
ECHA REACH: May require registration if imported into EU above one ton annually
SARA Title III (Sections 302, 313): Not listed
California Proposition 65: Not known to contain listed substances
International Inventories: Not listed in DSL/NDSL (Canada), not on AICS (Australia), EINECS/ELINCS (EU) registration may be needed in certain circumstances
Workplace Labelling: Maintain clear labeling in research and production environments to ensure proper handling and emergency response readiness
